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    SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME
    6.
    发明申请
    SUBSTRATE FOR ANALYZING COVERAGE OF SELF-ASSEMBLED MOLECULES AND ANALYZING METHOD USING THE SAME 审中-公开
    用于分析自组装分子的覆盖的基板和使用其的分析方法

    公开(公告)号：US20100015718A1

    公开(公告)日：2010-01-21

    申请号：US12517769

    申请日：2007-11-26

    申请人： Chil-Seong Ah ,  Ansoon Kim ,  Han-Young Yu ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In-Bok Baek ,  Chan-Woo Park ,  Seongjae Lee

    发明人： Chil-Seong Ah ,  Ansoon Kim ,  Han-Young Yu ,  Chang-Geun Ahn ,  Jong-Heon Yang ,  In-Bok Baek ,  Chan-Woo Park ,  Seongjae Lee

    IPC分类号： G01N33/00

    CPC分类号： G01N33/5308 ,  C12Q1/6825 ,  G01N33/54313 ,  G01N33/54393 ,  Y10T436/143333

    摘要： Provided are a substrate for analyzing the coverage of self-assembled molecules and a method for analyzing the coverage of the self-assembled molecules in nanowire and nanochannel patterned on solid surface, solid surface, or bulk solid surface by using the nanoparticles. According to the method, the presence of specific functional groups of self-assembled molecules and the degree of reaction can be analyzed by introducing nanoparticles to a biomaterial immobilization substrate including self-assembled molecules and measuring the number of gold nanoparticles existing on the surface. The substrate for analyzing the coverage of self-assembled molecules includes: a biomaterial immobilization substrate; a self-assembled molecular layer formed on the substrate and having a functional group capable of reacting with an amine group; a capture DNA molecule having an amine group bounded to the self-assembled molecular layer; and a probe DNA molecule bound to the capture DNA molecule and having nanoparticles attached to on the surface.

    摘要翻译： 本发明提供了一种用于分析自组装分子的覆盖物的底物以及通过使用纳米颗粒分析在固体表面，固体表面或体固体表面上图案化的纳米线和纳米通道中的自组装分子的覆盖率的方法。 根据该方法，可以通过将纳米颗粒引入包括自组装分子的生物材料固定化基质并测量表面上存在的金纳米颗粒的数量来分析自组装分子的特定官能团的存在和反应程度。 用于分析自组装分子的覆盖的底物包括：生物材料固定基质; 形成在基板上并具有能够与胺基反应的官能团的自组装分子层; 具有与自组装分子层结合的胺基的捕获DNA分子; 和与捕获DNA分子结合并且具有附着在表面上的纳米颗粒的探针DNA分子。

    METHOD FOR SELECTIVELY FUNCTIONALIZING NON-MODIFIED SOLID SURFACE AND METHOD FOR IMMOBILIZING ACTIVE MATERIAL ON THE FUNCTIONALIZED SOLID SURFACE
    8.
    发明申请
    METHOD FOR SELECTIVELY FUNCTIONALIZING NON-MODIFIED SOLID SURFACE AND METHOD FOR IMMOBILIZING ACTIVE MATERIAL ON THE FUNCTIONALIZED SOLID SURFACE 审中-公开
    用于选择性地功能化非改性固体表面的方法和在功能化固体表面上固定活性材料的方法

    公开(公告)号：US20100080932A1

    公开(公告)日：2010-04-01

    申请号：US12517193

    申请日：2007-05-14

    申请人： An-soon Kim ,  Han-Young Yu ,  In-Bok Baek ,  Jong-Heon Yang ,  Chang-Geun Ahn ,  Chan-Woo Park ,  Seong-Jae Lee ,  Chil-Seong Ah

    发明人： An-soon Kim ,  Han-Young Yu ,  In-Bok Baek ,  Jong-Heon Yang ,  Chang-Geun Ahn ,  Chan-Woo Park ,  Seong-Jae Lee ,  Chil-Seong Ah

    IPC分类号： B05D3/06

    CPC分类号： G01N33/54353 ,  B01J2219/00497

    摘要： Provided is a method for selectively functionalizing unmodified solid surface, not oxidized and nitrified, into an aldehyde group, and a method for immobilizing an active material such as bio material or functional material on the functionalized aldehyde solid surface through strong and stable chemical bonding. Differently from a conventional method immobilizing deoxyribonucleic acid (DNA) using a cross linker, the method of the present invention does not require a cross linker reaction step to thereby shorten a process. Also, since a cross linker is absent, the monomolecular layer on the surface of a device is thin, which reduces a perturbation effect by molecular layer. This is useful in fabrication of molecular electronic devices and bio-active devices. In addition, since the bio material or functional material is selectively immobilized only on the unmodified surface, the present invention can functionalize only a specific solid surface and develop a highly sensitive sensor and an improved functional device.

    摘要翻译： 提供了将未改性的固体表面官能化而未被氧化并硝化成醛基的方法，以及通过强力稳定的化学键将活性物质如生物材料或功能材料固定在官能化的醛固体表面上的方法。 与使用交联剂固定脱氧核糖核酸（DNA）的常规方法不同，本发明的方法不需要交联反应步骤，从而缩短了工艺。 此外，由于不存在交联剂，器件表面上的单分子层薄，这降低了分子层的扰动效应。 这在分子电子器件和生物活性器件的制造中是有用的。 此外，由于生物材料或功能材料仅选择性地固定在未改性的表面上，所以本发明只能使特定的固体表面官能化，并开发出高灵敏度的传感器和改进的功能元件。

    BIOSENSOR, MANUFACTURING METHOD THEREOF, AND BIOSENSING APPARATUS INCLUDING THE SAME
    9.
    发明申请
    BIOSENSOR, MANUFACTURING METHOD THEREOF, AND BIOSENSING APPARATUS INCLUDING THE SAME 审中-公开
    生物传感器，其制造方法和包括其的生物传感装置

    公开(公告)号：US20100013030A1

    公开(公告)日：2010-01-21

    申请号：US12443376

    申请日：2007-08-30

    申请人： Han-Young Yu ,  An-Soon Kim ,  Chil-Seong Ah ,  Jong-Heon Yang ,  In-Bok Baek ,  Chang-Geun Ahn ,  Seong-Jae Lee ,  Jin-Ho Yun

    发明人： Han-Young Yu ,  An-Soon Kim ,  Chil-Seong Ah ,  Jong-Heon Yang ,  In-Bok Baek ,  Chang-Geun Ahn ,  Seong-Jae Lee ,  Jin-Ho Yun

    IPC分类号： H01L29/66 ,  H01L21/30

    CPC分类号： G01N33/54366 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0887

    摘要： Provided is a biosensor with a three-dimensional multi-layered structure, a method for manufacturing the biosensor, and a biosensing apparatus including the biosensor. The biosensing apparatus includes: a chamber having an inlet through which a fluid containing a biomaterial enters and an outlet through which the fluid exits; and a plurality of biosensors inserted and fixed in the chamber. Each biosensor includes: a support unit having a fluid channel through which a fluid containing a biomaterial flows; and a sensing unit disposed on the support unit in such a way that the sensing unit is exposed three-dimensionally in the fluid channel of the support unit, the sensing unit being surface-treated with a reactive material that is to react with the biomaterial flowing through the fluid channel.

    摘要翻译： 本发明提供具有三维多层结构的生物传感器，生物传感器的制造方法以及包括生物传感器的生物传感装置。 所述生物传感装置包括：具有入口的腔室，含有生物材料的流体通过所述入口进入，所述流体通过所述出口流出; 以及插入并固定在所述室中的多个生物传感器。 每个生物传感器包括：具有流体通道的支撑单元，含有生物材料的流体通过该流体通道流动; 以及感测单元，其以这样的方式设置在所述支撑单元上，使得所述感测单元在所述支撑单元的流体通道中三维地暴露，所述感测单元用反应性材料进行表面处理，所述反应性材料与所述生物材料流动 通过流体通道。