公开(公告)号：US20180030093A1

公开(公告)日：2018-02-01

申请号：US15551116

申请日：2016-03-31

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte A. E. Hauser ,  Michael R. Reithofer

IPC: C07K7/64 ,  A61K8/64 ,  A61K9/00 ,  A61K9/06 ,  A61K8/04 ,  A61K47/42 ,  A61Q19/00

CPC classification number: C07K7/64 ,  A61K8/042 ,  A61K8/64 ,  A61K9/0019 ,  A61K9/06 ,  A61K47/42 ,  A61K2800/10 ,  A61K2800/91 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61Q19/00 ,  C07K5/123 ,  C07K5/126

Abstract: The invention relates to cyclic peptides of 3-9 amino acids comprising 2-7 aliphatic and 0-2 polar amino acids that are capable of self-assembling, wherein said aliphatic amino acids are arranged in decreasing hydrophobicity from N- to C-terminus and at least a portion of the cyclic peptide has to have its amino acids in alternating D- and L-configuration, as well as their use in hydrogels as well as co-gels or co-hydrogels. The hydrogels of the invention may be used in nanomedicine or drug delivery, cell culture or alternatively in electronic devices.

公开(公告)号：US10117946B2

公开(公告)日：2018-11-06

申请号：US14655223

申请日：2013-12-24

Applicant: Agency for Science, Technology and Research

Inventor： Michael R. Reithofer ,  Charlotte A. E. Hauser ,  Kiat Hwa Chan ,  Archana Mishra

IPC: A01N55/02 ,  A61K31/28 ,  A61K47/48 ,  A61K31/282 ,  A61K38/08 ,  A61K31/555

Abstract: The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

公开(公告)号：US10071183B2

公开(公告)日：2018-09-11

申请号：US14719674

申请日：2015-05-22

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte A. E. Hauser ,  Ulung Gondo Kusumo Khoe ,  Archana Mishra

IPC: A61K9/00 ,  A01N63/00 ,  A01N65/00 ,  A01N25/00 ,  A61K47/00 ,  C12N5/00 ,  C12N5/02 ,  A61L27/22 ,  A61K8/04 ,  A61K8/64 ,  A61Q19/00 ,  C07K5/062 ,  C07K5/072 ,  C07K5/083 ,  C07K5/103 ,  C07K7/06 ,  A61L27/52 ,  A61L27/54 ,  A61K38/00

CPC classification number: A61L27/22 ,  A61K8/042 ,  A61K8/64 ,  A61K38/00 ,  A61L27/52 ,  A61L27/54 ,  A61L2430/00 ,  A61Q19/00 ,  C07K5/06026 ,  C07K5/06043 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06069 ,  C07K5/06104 ,  C07K5/06113 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/1008 ,  C07K5/101 ,  C07K7/06

Abstract: The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hy-drogel that includes the amphiphilic linear peptide/peptoid. The amphiphilic linear pep-tide/peptoid is capable of forming, a hydrogel. These peptides/peptoids include short amphi-philic sequences with a hydrophobic portion of aliphatic amino acids and at least one acidic, neutral, or basic polar amino acid. The amphiphilic linear peptide/peptoid is build up of non repetitive aliphatic amino acids, which may be in the L- or D-form. A plurality of such pep-tides/peptoids assembles to supramolecular helical fibers and forms peptide hydrogels after assembly: A corresponding hydrogel is formed in aqueous solutions at physiological pH and is thus useful for inter alia cell culture, tissue engineering, and drug release. Such hydrogels which are rigid, biocompatible and entrapping up to 99.9% of water are also well suited for applications utilizing electronic devices.

公开(公告)号：US20180016304A1

公开(公告)日：2018-01-18

申请号：US15549874

申请日：2016-03-03

Applicant: Agency for Science, Technology and Research

Inventor： Charlotte A. E. Hauser ,  Michael R. Reithofer ,  Yihua Loo

IPC: C07K11/00 ,  A61K47/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/22

CPC classification number: C07K11/00 ,  A61K47/34 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L2400/06 ,  A61L2430/34 ,  G01N2800/7095

Abstract: The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these depsipeptides in formulating hydrogels, co-gels or co-hydrogels, and pharmaceutical compositions or biomedical device or surgical implants or kits comprising these depsipeptides for various therapeutic applications such as regenerative medicine, tissue regeneration and tissue re-placement.