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11 条记录 (耗时 0.03 秒)

    Adaptive phase contrast microscope
    2.
    发明授权
    Adaptive phase contrast microscope 有权
    自适应相差显微镜

    公开(公告)号：US09069175B2

    公开(公告)日：2015-06-30

    申请号：US13442251

    申请日：2012-04-09

    申请人： Douglas J. Koebler ,  Alfred Blalock Bahnson

    发明人： Douglas J. Koebler ,  Alfred Blalock Bahnson

    IPC分类号： G02B21/14

    CPC分类号： G02B21/14

    摘要： An optical microscope is provided with an adjustable optical phase ring. The adjustable ring provides a way to compensate for distortion in the visible phase ring before the light reaches the sample. In an inverted microscope, when observing transparent cells under a liquid, the visible light phase ring is distorted. By the use of a Liquid Crystal Display (LCD) in place of a fixed ring, the projected ring is adjusted to realign the light and produce phase. In a typical micro plate, the meniscus formed produces a lens effect that is realigned by providing changes in the position and pattern, to allow phase imaging over a wider portion of the well. The realignment of the ring can be manual or automated and can be dynamically adjusted based upon an observed image of the sample.

    摘要翻译： 光学显微镜上设有一个可调节的光学相位环。 可调节环提供了在光到达样品之前补偿可见相位环中的失真的方法。 在倒置显微镜中，当观察液体下的透明细胞时，可见光相位环变形。 通过使用液晶显示器（LCD）代替固定环，调整投影环以重新对准光并产生相位。 在典型的微板中，形成的弯液面产生通过提供位置和图案的改变来重新对准的透镜效应，以允许在较宽部分的孔上进行相位成像。 环的重新对准可以是手动的或自动的，并且可以基于样本的观察图像来动态地调整。

    ADAPTIVE PHASE CONTRAST MICROSCOPE
    3.
    发明申请
    ADAPTIVE PHASE CONTRAST MICROSCOPE 有权
    自适应相位显微镜

    公开(公告)号：US20120257040A1

    公开(公告)日：2012-10-11

    申请号：US13442251

    申请日：2012-04-09

    申请人： Douglas J. Koebler ,  Alfred Blalock Bahnson

    发明人： Douglas J. Koebler ,  Alfred Blalock Bahnson

    IPC分类号： G02B21/14 ,  H04N7/18 ,  G02F1/13

    CPC分类号： G02B21/14

    摘要： An optical microscope is provided with an adjustable optical phase ring. The adjustable ring provides a way to compensate for distortion in the visible phase ring before the light reaches the sample. In an inverted microscope, when observing transparent cells under a liquid, the visible light phase ring is distorted. By the use of a Liquid Crystal Display (LCD) in place of a fixed ring, the projected ring is adjusted to realign the light and produce phase. In a typical micro plate, the meniscus formed produces a lens effect that is realigned by providing changes in the position and pattern, to allow phase imaging over a wider portion of the well. The realignment of the ring can be manual or automated and can be dynamically adjusted based upon an observed image of the sample.

    摘要翻译： 光学显微镜上设有一个可调节的光学相位环。 可调节环提供了在光到达样品之前补偿可见相位环中的失真的方法。 在倒置显微镜中，当观察液体下的透明细胞时，可见光相位环变形。 通过使用液晶显示器（LCD）代替固定环，调整投影环以重新对准光并产生相位。 在典型的微板中，形成的弯液面产生通过提供位置和图案的改变来重新对准的透镜效应，以允许在较宽部分的孔上进行相位成像。 环的重新对准可以是手动的或自动的，并且可以基于样本的观察图像来动态地调整。

    Method and apparatus for determination of analyte concentration
    4.
    发明授权
    Method and apparatus for determination of analyte concentration 失效
    用于测定分析物浓度的方法和装置

    公开(公告)号：US5954954A

    公开(公告)日：1999-09-21

    申请号：US879336

    申请日：1997-06-20

    申请人： Raymond K. Houck ,  Douglas J. Koebler ,  Glen P. Williams ,  Joseph M. Levy ,  Victor G. Danielson

    发明人： Raymond K. Houck ,  Douglas J. Koebler ,  Glen P. Williams ,  Joseph M. Levy ,  Victor G. Danielson

    IPC分类号： B01D11/02 ,  B01D15/08 ,  G01N1/34 ,  G01N1/40 ,  G01N30/06 ,  G01N33/24

    CPC分类号： G01N1/34 ,  B01D11/0203 ,  G01N2001/4061 ,  G01N2030/062 ,  G01N33/24

    摘要： The present invention pertains to an apparatus for gathering analyte. The apparatus comprises a pumping mechanism for pumping solvent at supercritical pressure. The apparatus also comprises an extraction mechanism which receives a first sample and at least a second sample separate and distinct from the first sample and extract analyte from them essentially simultaneously. The extraction mechanism is connected to the pump mechanism to receive solvent at supercritical pressure for extracting the analyte from the samples. The apparatus additionally comprises a collection mechanism for collecting analyte from the solvent after the analyte has been extracted from the samples. The collection mechanism receives the supercritical solvent having the analyte extracted from the samples from the extraction mechanism. The present invention pertains to a method for extracting analyte. The method comprises the steps of pumping solvent at a supercritical pressure. Then there is the step of extracting analyte from N samples essentially simultaneously with the solvent at a supercritical pressure, where N is greater than or equal to two and is an integer. The N samples are separate and distinct from each other. Then there is the step of collecting the analyte of the N samples from the solvent.

    摘要翻译： 本发明涉及用于收集分析物的装置。 该装置包括用于在超临界压力下泵送溶剂的泵送机构。 该装置还包括提取机构，其接收第一样品和至少第二样品，其与第一样品分离并且不同，并且基本上同时从其中提取分析物。 提取机构连接到泵机构以在超临界压力下接收溶剂以从样品中提取分析物。 该装置另外包括用于在从样品中提取分析物之后从溶剂收集分析物的收集机构。 收集机构接收来自提取机构的样品提取的分析物的超临界溶剂。 本发明涉及提取分析物的方法。 该方法包括以超临界压力泵送溶剂的步骤。 然后，在超临界压力下，基本上与溶剂同时从N个样品中提取分析物，其中N大于或等于2，并且为整数。 N个样本是分开的并且彼此不同。 然后是从溶剂中收集N个样品的分析物的步骤。

    Automated supercritical fluid extraction method and apparatus
    5.
    发明授权
    Automated supercritical fluid extraction method and apparatus 失效
    自动超临界流体萃取方法及装置

    公开(公告)号：US5866004A

    公开(公告)日：1999-02-02

    申请号：US524916

    申请日：1995-09-08

    申请人： Raymond K. Houck ,  Douglas J. Koebler ,  Glen P. Williams ,  Kenneth J. Kato ,  Robert D. Parks ,  Paul A. Bauer, Jr.

    发明人： Raymond K. Houck ,  Douglas J. Koebler ,  Glen P. Williams ,  Kenneth J. Kato ,  Robert D. Parks ,  Paul A. Bauer, Jr.

    IPC分类号： B01D11/02 ,  B01D15/08 ,  G01N1/34 ,  G01N1/40 ,  G01N30/06 ,  G01N33/24 ,  B01D11/00

    CPC分类号： G01N1/34 ,  B01D11/0203 ,  G01N2001/4061 ,  G01N2030/062 ,  G01N33/24 ,  Y10T436/255

    摘要： A supercritical fluid extraction (SFE) system. The SFE system includes a mechanism for providing supercritical fluid for extracting analyte from a sample. The SFE system also includes an extraction vessel and a mechanism for moving the extraction vessel into fluidic communication with the SFE system so that supercritical fluid can flow through the extraction vessel and extract analyte from the sample. Preferably, the SFE system is additionally comprised of a mechanism for holding a plurality of extraction vessels and an extraction chamber assembly. In this design, the moving mechanism selectively moves an extraction vessel from the holding mechanism into the extraction chamber in fluidic communication with the SFE system. Preferably, the SFE system further includes a computer for controlling the functions of the SFE system. The computer, for instance, could automatically and sequentially control the supercritical fluid extractions of the samples within the holding mechanism. The SFE system preferably includes a mechanism for collecting analyte from the fluid with analyte. The collecting mechanism is in fluid communication with extraction chamber assembly and preferably includes a restrictor for controlling the flow of fluid with analyte to the collecting mechanism. The restrictor converts the fluid with analyte from a first supercritical pressure to a second pressure which is less than the first supercritical pressure.

    摘要翻译： 超临界流体萃取（SFE）系统。 SFE系统包括提供用于从样品中提取分析物的超临界流体的机制。 SFE系统还包括提取容器和用于将提取容器移动到与SFE系统流体连通的机构，使得超临界流体可以流过提取容器并从样品中提取分析物。 优选地，SFE系统还包括用于保持多个提取容器和提取室组件的机构。 在该设计中，移动机构选择性地将提取容器从保持机构移动到与SFE系统流体连通的提取室中。 优选地，SFE系统还包括用于控制SFE系统的功能的计算机。 例如，计算机可以自动和顺序地控制保持机构内的样品的超临界流体萃取。 SFE系统优选地包括用于从具有分析物的流体收集分析物的机构。 收集机构与提取室组件流体连通，并且优选地包括限制器，用于控制具有分析物的流体与收集机构的流动。 限流器将具有分析物的流体从第一超临界压力转换为小于第一超临界压力的第二压力。

    Devices, systems and methods for assisting blood flow
    8.
    发明授权
    Devices, systems and methods for assisting blood flow 失效
    用于辅助血液流动的装置，系统和方法

    公开(公告)号：US07588530B2

    公开(公告)日：2009-09-15

    申请号：US11184231

    申请日：2005-07-19

    申请人： Marlin Stephen Heilman ,  Douglas J. Koebler ,  Daniel R. Moore ,  Edward K. Prem

    发明人： Marlin Stephen Heilman ,  Douglas J. Koebler ,  Daniel R. Moore ,  Edward K. Prem

    IPC分类号： A61M1/10

    CPC分类号： A61M1/1046 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1041 ,  A61M1/1049 ,  A61M1/1055 ,  A61M1/106 ,  A61M1/1086 ,  A61M1/1087 ,  A61M1/1098 ,  A61M1/12 ,  A61M1/122

    摘要： A pump includes a flexible conduit, at least one valve attached to the flexible conduit about the perimeter of the valve; and a drive mechanism to move the valve to pump blood within the conduit. The drive mechanism can, for example, be adapted to complete a single stroke during each heart ventricle contraction and/or to complete multiple strokes (that is, oscillate) during a single contraction. The moveable valve includes a plurality of openings. Each of the plurality of openings has a closure mechanism in operative connection therewith which is operable to at least partially close the opening to which it is operatively connected when the moveable valve is moved forward and to open the opening to which it is operatively connected when the valve is moved rearward. In one embodiment, each closure mechanism includes a flap of resilient material.

    摘要翻译： 泵包括柔性导管，至少一个阀，围绕阀的周边连接到柔性导管; 以及驱动机构，用于移动阀以泵送导管内的血液。 例如，驱动机构可以适于在每次心室收缩期间完成单个冲程和/或在单次收缩期间完成多个冲程（即，振荡）。 可移动阀包括多个开口。 多个开口中的每一个具有与其可操作地连接的闭合机构，其可操作以在可移动阀向前移动时至少部分地关闭其可操作地连接的开口，并且当可移动阀向前移动时打开其可操作地连接的开口 阀向后移动。 在一个实施例中，每个闭合机构包括弹性材料的翼片。

    Fluid restrictor apparatus and method for making the same
    9.
    发明授权
    Fluid restrictor apparatus and method for making the same 失效

    公开(公告)号：US5316262A

    公开(公告)日：1994-05-31

    申请号：US828729

    申请日：1992-01-31

    申请人： Douglas J. Koebler

    发明人： Douglas J. Koebler

    IPC分类号： F16K7/06 ,  G01M3/00

    CPC分类号： F16K7/061 ,  G01M3/007 ,  Y10T137/0391 ,  Y10T137/2196

    摘要： The present invention is an apparatus for restricting the flow of fluid. The apparatus defines a tubular member having a channel. The tubular member has a first portion in which the channel has a first cross sectional area. There is also a second portion for restricting the flow of fluid defined by a reproducible deformity in the channel such that the channel has a second cross sectional area which is smaller than the first cross sectional area of the first portion. The tubular member further defines a third portion having a third cross sectional area which is greater than the second cross sectional area of the second portion. All of the cross sectional dimensions of the second and third portions are disposed within a cylindrical envelope having a diameter equal to the diameter of the first portion and extending therefrom. The tubular member is comprised of a material having sufficient rigidity to maintain a preferred reproducible permanent deformity in the channel. Portion has an essentially constant outside diameter and wherein all cross sectional dimensions of the tubular member are less than or equal to the diameter of the first portion and all of the cross sectional dimensions of the second and third portions are disposed within a cylindrical envelope having a diameter equal to the diameter of the first portion and extending therefrom. Preferably, the deformity is defined by a spherical indentation and the tubular member is comprised of stainless steel. The present invention is also a method of forming a fluid restrictor comprising the steps of first placing a tubular member having a channel and a predetermined outside diameter into a fixed relationship with a deforming apparatus. Then, there is the step of deforming the tubular member in a reproducible manner such that a cross sectional area of the channel is decreased so flow of fluid through the channel is restricted a desired amount. The deforming step does not cause the tubular member to flare and all of the cross sectional dimensions of the second and third portions disposed within a cylindrical envelope having a diameter equal to the diameter of the first portion and extending therefrom. Preferably, the deforming step includes the step of forcing a shaping element of the deforming apparatus against the tubular member. Alternatively, the deforming apparatus can be used to adjust the magnitude of fluid restriction during operation of the fluid restrictor.