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1.发明申请公开(公告)号：US20220305460A1
公开(公告)日：2022-09-29
申请号：US17696917
申请日：2022-03-17
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , JIALI LIAO , EDWIN LOZANO
IPC: B01J20/285 , B01J20/289 , B01J20/30 , B01J20/28 , C07K1/16 , B01D15/38
Abstract: The subject invention pertains to proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic 1,3-droxoisoindolin-2-yl group functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of one, two, three, four, or five atoms between the hydrophobic group and the support matrix.
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公开(公告)号：US20230127357A1
公开(公告)日：2023-04-27
申请号：US18046967
申请日：2022-10-17
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , JIALI LIAO , CALLISTA KATRINA ASUNCION , EDWIN LOZANO
IPC: C07K1/16
Abstract: The subject invention pertains to mixed mode chromatography ligands and chromatography matrices suitable for the purification of proteins from biological sources or biological samples. Methods of making chromatography matrices comprising the disclosed ligands and using the disclosed chromatography matrices are also provided.
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公开(公告)号：US20210069692A1
公开(公告)日：2021-03-11
申请号：US17012108
申请日：2020-09-04
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , XUEMEI HE , HONG CHEN , YUEPING XU , JIALI LIAO
Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
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公开(公告)号：US20240261775A1
公开(公告)日：2024-08-08
申请号：US18437294
申请日：2024-02-09
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , XUEMEI HE , HONG CHEN , YUEPING XU , JIALI LIAO
CPC classification number: B01J41/14 , B01J41/07 , B01J47/014 , B01J47/02 , C07K1/18 , C12N9/88 , C12Y402/01045 , B01J2220/52
Abstract: Chromatography resins having anionic exchange-hydrophobic mixed mode ligands and methods of using such resins are provided.
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公开(公告)号：US20210086165A1
公开(公告)日：2021-03-25
申请号：US16967429
申请日：2019-02-05
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , HONG CHEN , YUEPING XU , JIALI LIAO , XUEMEI HE
Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
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Patent Agency Ranking
公开(公告)号：US20240367143A1
公开(公告)日：2024-11-07
申请号：US18653214
申请日：2024-05-02
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： SHAWN DARNALL , BRIAN PANGANIBAN , DANNI WANG , CHRISTOPHER BELISLE , ZACHARY CLAUSS
Abstract: Provided herein is a chromatography media composed of a porous solid substrate (such as a membrane, metal, or metallic alloy) that is coated with hydroxyapatite (IA). Also provided is a chromatography media comprising a HA-coated substrate and uses thereof. Thus this disclosure provides a chromatography media composed of a porous solid substrate (such as a membrane, metal, or metallic alloy) that is coated with I-IA. Also provided is a chromatography media comprising a HA-coated substrate and uses thereof. Methods of preparing the HA-coated substrate are also provided.
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公开(公告)号：US20230264171A1
公开(公告)日：2023-08-24
申请号：US18307991
申请日：2023-04-27
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , HONG CHEN , YUEPING XU , JIALI LIAO , XUEMEI HE
IPC: B01J20/26 , B01D15/36 , B01J20/32 , C07K16/06 , B01J20/289
CPC classification number: B01J20/262 , B01D15/363 , B01J20/3285 , B01J20/3227 , B01J20/3208 , B01J20/3219 , C07K16/065 , B01J20/289 , B01J20/3248 , B01J20/3253 , B01D15/3847
Abstract: Chromatography resins having mixed mode ligands and methods of using such resins are provided.
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公开(公告)号：US20210040382A1
公开(公告)日：2021-02-11
申请号：US16987441
申请日：2020-08-07
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： CHRISTOPHER BELISLE , PRAVEENA D. GARIMELLA , LEILA AMERY RANIS
IPC: C09K11/02 , C09K11/06 , G01N33/545
Abstract: Polymer dots comprising a functionalized fluorescent polymer and an amphiphilic molecule are provided.
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公开(公告)号：US20240367142A1
公开(公告)日：2024-11-07
申请号：US18652908
申请日：2024-05-02
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： BRIAN PANGANIBAN , SHAWN DARNALL , DANNI WANG , CHRISTOPHER BELISLE
IPC: B01J20/04 , B01J20/282 , C01B25/32
Abstract: Provided herein is a chromatography media composed of a particulate substrate (such as beads or other particulate substrates) that is coated with hydroxyapatite (HA) and in which the particulate substrate used as the base upon which calcium phosphate (CaP) is formed is treated with heat to remove the substrate, convert the CaP to HA, and form the desired HA microstructure so as to form a templated porous HA substrate (TPHA substrate). Also provided is a chromatography media (optionally contained within a column) comprising a TPHA substrate (e.g., a plurality of TPHA particles). The TPHA particles are porous or macroporous and uses thereof.
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公开(公告)号：US20240367141A1
公开(公告)日：2024-11-07
申请号：US18652860
申请日：2024-05-02
Applicant: BIO-RAD LABORATORIES, INC.
Inventor： BRIAN PANGANIBAN , SHAWN DARNALL , DANNI WANG , CHRISTOPHER BELISLE
Abstract: This disclosure relates to particulate hydroxyapatite (HA)-coated substrates, methods of making particulate HA-coated substrates, and methods of using particulate HA-coated substrates. Thus, the disclosure provides chromatography media composed of a particulate substrate (such as polymer beads or other particulate substrates) that is coated with HA. Also provided is a chromatography media (optionally contained within a column) comprising a HA-coated substrate (e.g., a plurality of beads or another particulate substrate that is coated with HA). The beads or particulate substrate can be a porous or non-porous substrate.
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