-
公开(公告)号：US11739098B2
公开(公告)日：2023-08-29
申请号：US17699944
申请日：2022-03-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tasir Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC: C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC classification number: C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are compounds of Formula (I)
or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.-
公开(公告)号：US20230150979A1
公开(公告)日：2023-05-18
申请号：US17425336
申请日：2020-01-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Trevor C. Sherwood , Michael G. Yang , John L. Gilmore , Yanlei Zhang , Zili Xiao , Qingjie Liu
IPC: C07D403/12 , C07D413/12 , C07D237/24 , C07D213/82 , C07D413/14 , C07D401/14 , C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14
CPC classification number: C07D403/12 , C07D413/12 , C07D237/24 , C07D213/82 , C07D413/14 , C07D401/14 , C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07B2200/05
Abstract: Compounds having the following formula (I): (Formula (I)) or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNa, by acting on Tyk-2 to cause signal transduction inhibition.
-
公开(公告)号：US20190076450A1
公开(公告)日：2019-03-14
申请号：US16188444
申请日：2018-11-13
Applicant: Bristol-Myers Squibb Company
Inventor： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC: A61K31/695 , C07F7/08 , A61K31/505 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/661 , C07F9/09 , C07F9/572 , C07F9/54 , C07C235/46 , C07C323/25 , C07C217/74 , C07C275/26 , C07D213/38 , C07D209/46 , C07C251/44 , C07C251/42 , C07C251/38 , C07C323/29 , C07D241/04 , C07D215/14 , A61K31/135 , C07D213/69 , C07D213/32 , C07C251/54 , C07C219/24 , C07C217/52 , C07D333/16 , C07D319/20 , C07D311/76 , C07D311/58 , C07D309/12 , C07D309/06 , C07D277/24 , C07D239/26 , C07D231/12 , C07D217/24 , C07C317/28 , C07C271/34 , C07C251/52 , C07C233/41 , C07C217/58 , C07C215/42 , C07F9/655 , C07F9/62 , C07D305/08 , C07D241/12 , C07D231/20 , C07D215/12 , C07D213/70
Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
-
公开(公告)号：US10166249B2
公开(公告)日：2019-01-01
申请号：US15648250
申请日：2017-07-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC: A61K31/695 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F9/62 , C07F9/655 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
-
公开(公告)号：US20230098244A1
公开(公告)日：2023-03-30
申请号：US17699944
申请日：2022-03-21
Applicant: Bristol-Myers Squibb Company
Inventor： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tsair Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC: C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
Abstract: Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
-
Patent Agency Ranking
公开(公告)号：US11447466B2
公开(公告)日：2022-09-20
申请号：US16635593
申请日：2018-08-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , Dharmpal S. Dodd , Tasir Shamsul Haque , Brian K. Whiteley , John L. Gilmore
IPC: A61K31/4545 , A61P29/00 , A61P37/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14
Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: Y is Formula (II), or Formula (III); R1, R2, R2a, R2b, R2c, R3, R4, R5, m, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
-
公开(公告)号：US11058696B2
公开(公告)日：2021-07-13
申请号：US16879824
申请日：2020-05-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC: A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
-
公开(公告)号：US20170304332A1
公开(公告)日：2017-10-26
申请号：US15648250
申请日：2017-07-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC: A61K31/695 , C07F9/6553 , C07F9/655 , C07F9/6509 , C07F9/6503 , C07F9/62 , C07F9/572 , C07F9/54 , C07F9/117 , C07F9/09 , C07F7/08 , C07D333/16 , C07D319/20 , C07D311/76 , C07D311/58 , C07D309/12 , C07D309/06 , C07D305/08 , C07D277/24 , C07D241/12 , C07D241/04 , C07D239/26 , C07D231/20 , C07D231/12 , C07D217/24 , C07D215/14 , C07D215/12 , C07D213/70 , C07D213/69 , C07D213/38 , C07D213/32 , C07D209/46 , C07C323/29 , C07C323/25 , C07C321/28 , C07C321/22 , C07C321/16 , C07C317/32 , C07C317/28 , C07C275/26 , C07C271/34 , C07C251/54 , C07C251/52 , C07C251/50 , C07C251/44 , C07C251/42 , C07C251/38 , C07C235/46 , C07C233/65 , C07C233/41 , C07C219/24 , C07C217/74 , C07C217/58 , C07C217/52 , C07C215/42 , A61K31/661 , A61K31/505 , A61K31/4965 , A61K31/47 , A61K31/4409 , A61K31/4406 , A61K31/4402 , A61K31/44 , A61K31/426 , A61K31/4174 , A61K31/415 , A61K31/381 , A61K31/352 , A61K31/351 , A61K31/337 , A61K31/27 , A61K31/24 , A61K31/222 , A61K31/17 , A61K31/166 , A61K31/165 , A61K31/15 , A61K31/137 , A61K31/135 , C07C2601/04 , C07C2601/08 , C07C2603/74 , C07C2602/10 , C07C2601/02
CPC classification number: A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
-
公开(公告)号：US09770459B2
公开(公告)日：2017-09-26
申请号：US15337843
申请日：2016-10-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC: C07D217/00 , A61K31/695 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
CPC classification number: A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
-
公开(公告)号：US11878975B2
公开(公告)日：2024-01-23
申请号：US16955097
申请日：2018-12-18
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , John L. Gilmore , Tasir Shamsul Haque , Trevor C. Sherwood , Brian K. Whiteley , Shoshana L. Posy , Sreekantha Ratna Kumar , Laxman Pasunoori , Srinivasan Kunchithapatham Duraisamy , Subramanya Hegde , Rushith Kumar Anumula , Pitani Veera Venkata Srinivas
IPC: C07D471/08 , C07D487/08 , C07D519/00 , C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
CPC classification number: C07D471/04 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/02 , C07D487/04 , C07D491/08
Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
-
-
-
-
-
-
-
-
-
Search Results
34
records
(took 0.028 seconds)
