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公开(公告)号：US10221232B2
公开(公告)日：2019-03-05
申请号：US15404749
申请日：2017-01-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , David Fabrizio , Martin C. Wright , Patrick Gage , John Mendlein
IPC: C07K14/78 , C07K14/47 , C07K14/71 , A61K38/39 , A61K39/395 , C07K19/00 , C12N15/10 , C40B30/04 , C40B40/08 , A61K38/18 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , A61K47/60 , A61K47/64 , A61K47/68 , C07K16/22 , C07K16/28 , A61K39/00 , C40B40/10
Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US09017655B2
公开(公告)日：2015-04-28
申请号：US13692555
申请日：2012-12-03
Applicant: Bristol-Myers Squibb Company
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/17 , A61K38/39 , C07K14/78 , C07K14/435 , C07K14/475 , C07K16/28
CPC classification number: C07K14/78 , A61K38/39 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K14/475 , C07K16/2863 , C07K2317/31 , C07K2317/34 , C07K2317/92 , C07K2318/20 , C07K2319/30
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
Abstract translation: 本发明涉及包含EGFR结合结构域和用于诊断，研究和治疗应用的不同IGFIR结合结构域的双特异性分子。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码创新蛋白质的多核苷酸的载体。 示例性双特异性分子包括基于第十纤连蛋白III型结构域的抗体样蛋白二聚体。
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公开(公告)号：US09862758B2
公开(公告)日：2018-01-09
申请号：US15070572
申请日：2016-03-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K19/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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4.发明授权公开(公告)号：US11149077B2
公开(公告)日：2021-10-19
申请号：US16244851
申请日：2019-01-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , David Fabrizio , Martin C. Wright , Patrick Gage , John Mendlein
IPC: C07K14/78 , C07K14/71 , C07K16/28 , A61K38/17 , A61K38/39 , A61K39/395 , A61K47/10 , A61K47/60 , A61K47/64 , A61K47/68 , C12N15/10 , C40B30/04 , C40B40/08 , A61K38/18 , C07K14/00 , C07K14/765 , C07K14/79 , C07K16/00 , C07K14/47 , A61K39/00 , C07K19/00 , C40B40/10
Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.
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公开(公告)号：US10995131B2
公开(公告)日：2021-05-04
申请号：US15826196
申请日：2017-11-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07K19/00 , C40B40/08 , C40B40/10 , C12N15/10 , C12N15/09 , A61K38/39 , C07H21/04 , A61K38/00 , A61K39/00 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
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Patent Agency Ranking
公开(公告)号：US10954286B2
公开(公告)日：2021-03-23
申请号：US16206551
申请日：2018-11-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/16 , A61K38/39 , C07K14/78 , C07K16/28 , C07K14/475 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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公开(公告)号：US09328157B2
公开(公告)日：2016-05-03
申请号：US14071069
申请日：2013-11-04
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yan Chen , Elena Getmanova , Martin C. Wright , Alan S. Harris , Ai Ching Lim , Jochem Gokemeijer , Lin Sun , Michael Wittekind
IPC: C07K14/78 , C07H21/04 , C12N15/09 , C07K14/47 , C07K14/52 , C07K16/28 , C07K16/30 , A61K38/39 , A61K38/00 , A61K39/00
CPC classification number: C07K14/78 , A61K38/00 , A61K38/39 , A61K2039/505 , C07H21/04 , C07K14/4703 , C07K14/52 , C07K16/2863 , C07K16/30 , C07K19/00 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C12N15/09
Abstract: The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
Abstract translation: 本公开内容涉及新型血管内皮生长因子受体（VEGFR）结合多肽和使用这些多肽抑制由血管内皮生长因子（VEGF）介导的生物活性的方法。 本公开还提供了与单结构域结合多肽相关的各种改进。
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公开(公告)号：US12194110B2
公开(公告)日：2025-01-14
申请号：US17483393
申请日：2021-09-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria N. Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie Lafont , Daniel Cohen
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US11173219B2
公开(公告)日：2021-11-16
申请号：US16520965
申请日：2019-07-24
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Paul E. Morin , David Donnelly , Dasa Lipovsek , Jochem Gokemeijer , Maria Jure-Kunkel , David Fabrizio , Martin C. Wright , Douglas Dischino , Samuel J. Bonacorsi, Jr. , Ralph Adam Smith , Virginie LaFont , Daniel Cohen
Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.
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公开(公告)号：US10183987B2
公开(公告)日：2019-01-22
申请号：US15684595
申请日：2017-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stuart Emanuel , Linda Engle , Ray Camphausen , Martin C. Wright , Ginger Chao Rakestraw , Marco Gottardis , Joan Carboni
IPC: A61K38/16 , A61K38/39 , C07K14/475 , C07K14/78 , C07K16/28 , C12N5/10 , C12N15/09 , C12N15/63 , A61K39/395 , A61K45/06 , A61K39/00
Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.
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