公开(公告)号：US20220304804A1

公开(公告)日：2022-09-29

申请号：US17841912

申请日：2022-06-16

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24

Abstract: A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.

公开(公告)号：US11298117B2

公开(公告)日：2022-04-12

申请号：US16738516

申请日：2020-01-09

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Tal Reich ,  Paul Kaye

IPC: A61F2/24 ,  A61M27/00 ,  A61B17/00

Abstract: A method is provided, including (1) identifying the subject as having mitral valve regurgitation; (2) during a medical procedure, in response to identifying the subject as having mitral valve regurgitation, implanting a prosthetic valve at a mitral valve site of the heart; and (3) during the same medical procedure, implanting a therapeutic septal device at a septum of the heart. Other embodiments are also described.

公开(公告)号：US11135059B2

公开(公告)日：2021-10-05

申请号：US16802353

申请日：2020-02-26

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC: A61F2/24

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US11969163B2

公开(公告)日：2024-04-30

申请号：US17181961

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

IPC: A61B17/04 ,  A61B17/00 ,  A61F2/24

CPC classification number: A61B17/0401 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61B2017/00243 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/243 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2230/0041 ,  A61F2230/005

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be expanded radially within the heart into an at least partially-expanded configuration while at least a portion of the central valve section is situated outside of a space opening of the annular spacer, and moved upstream while remaining in the at least partially-expanded configuration until the anchoring protrusion engages the annular spacer.

公开(公告)号：US11653910B2

公开(公告)日：2023-05-23

申请号：US17875589

申请日：2022-07-28

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

CPC classification number: A61B17/0401 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2457 ,  A61B2017/00243 ,  A61B2017/0441 ,  A61B2017/0464 ,  A61F2/243 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/2466 ,  A61F2220/0016 ,  A61F2230/005 ,  A61F2230/0041

Abstract: A transluminal sheath is advanced transseptally into a left atrium of the subject. A distal end of a surrounding-sheath, having an anchor disposed therein, is advanced via a distal end of the transluminal sheath, into a left ventricle of the subject via a commissure of the mitral valve. While the distal end of the surrounding-sheath is in the left ventricle, the surrounding-sheath is pulled proximally with respect to the anchor to expose the anchor. While the distal end of the surrounding-sheath is in the left ventricle, mitral valve tissue that is within the left ventricle is encircled by helically wrapping the anchor around the mitral valve tissue. Subsequently, the surrounding-sheath is extracted from the heart. Other embodiments are also described.

公开(公告)号：US12053380B2

公开(公告)日：2024-08-06

申请号：US17841912

申请日：2022-06-16

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24 ,  A61F2/82

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/828 ,  A61F2220/0025 ,  A61F2230/001 ,  A61F2230/0067 ,  A61F2250/0039

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US11872130B2

公开(公告)日：2024-01-16

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24 ,  A61F2/848 ,  A61F2/82

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/828 ,  A61F2220/0025 ,  A61F2230/001 ,  A61F2230/0067 ,  A61F2250/0039

Abstract: A prosthetic heart valve implant is provided including a frame shaped so as to define upstream and downstream openings at upstream and downstream ends of the frame, respectively, when the implant is in an expanded state for implantation at a heart native valve. A sheet is coupled to the frame. When the implant is in the expanded state, the frame is shaped so as to define the following longitudinal portions arranged along a central longitudinal axis of the prosthetic heart valve implant: a substantially cylindrical mid portion having a diameter greater than respective diameters of the upstream and the downstream ends of the frame; an upstream portion, extending upstream and radially inward from the mid portion; and a downstream portion, extending downstream and radially inward from the mid portion. Other embodiments are also described.

公开(公告)号：US11426155B2

公开(公告)日：2022-08-30

申请号：US16680739

申请日：2019-11-12

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

Abstract: A transluminal sheath is advanced into a femoral vein of a subject, through an inferior vena cava of the subject, into a right atrium of a heart of the subject, and transseptally into a left atrium of the heart. A surrounding-sheath is advanced out of a distal end of the transluminal sheath, into the left atrium, and toward a commissure of a mitral valve of the heart. A commissural helix is implanted at the commissure by advancing the commissural helix out of the surrounding-sheath and through the commissure into a left ventricle of the heart, such that the commissural helix wraps around at least some chordae tendineae at the commissure and facilitates sealing of the commissure. Subsequently to the implantation of the commissural helix, the surrounding-sheath is extracted from the heart. Other embodiments are also described.

公开(公告)号：US20210393402A1

公开(公告)日：2021-12-23

申请号：US17466785

申请日：2021-09-03

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Yuval Zipory ,  Tal Reich ,  Yaron Herman ,  Gil Hacohen ,  Eran Miller ,  Rotem Neeman ,  Natalia Kruglova

IPC: A61F2/24

Abstract: Apparatus is provided, including: (A) a valve body (204) including a first frame (206) shaped to define a lumen therethrough, and a valve member (205) disposed within the lumen, (B) an upstream support (210), configured to be placed against an upstream surface of a native heart valve, and (C) a flexible sheet (214) that couples the upstream support to the valve body. The valve body has a compressed state in which the first frame has a first diameter, and an expanded state in which the first frame has a second diameter that is greater than the first diameter. The support includes a second frame (212) that has a compressed state, and an expanded state in which the second frame is annular, has an inner perimeter that defines an opening through the second frame, and has an outer perimeter. Other embodiments are also described.

公开(公告)号：US10925595B2

公开(公告)日：2021-02-23

申请号：US16740659

申请日：2020-01-13

Applicant: CARDIOVALVE LTD.

Inventor： Gil Hacohen ,  Yossi Gross ,  Tal Reich

IPC: A61B17/04 ,  A61F2/24 ,  A61B17/00

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular spacer configured for implantation with a native heart valve opening and a central valve section configured for disposal within the annular spacer. The central valve section may include at least one anchoring protrusion configured to anchor the central valve section against axial movement relative to the annular spacer. During deployment, the central valve section may be advanced downstream beyond the implanted annular spacer, and moved upstream until the anchoring protrusion engages the annular spacer.