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    METHOD OF TARGETING GENE DELIVERY USING VIRAL VECTORS
    5.
    发明申请
    METHOD OF TARGETING GENE DELIVERY USING VIRAL VECTORS 有权
    使用病毒载体靶向基因传递的方法

    公开(公告)号：US20160222409A1

    公开(公告)日：2016-08-04

    申请号：US14338947

    申请日：2014-07-23

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： David Baltimore ,  Pin Wang ,  Lili Yang

    IPC: C12N15/86

    CPC classification number: C12N15/86 ,  A61K2039/505 ,  C07K16/2887 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2799/027 ,  C12N2810/80 ,  C12N2810/851 ,  C12N2810/859 ,  Y02A50/386 ,  Y02A50/396

    Abstract: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

    Abstract translation: 提供了使用病毒将编码目标基因的多核苷酸递送至靶细胞的方法和组合物。 病毒包膜包含识别和结合靶细胞表面上的组分的细胞特异性结合决定簇，导致病毒的内吞。 单独的融合分子也存在于包膜上并促进多核苷酸穿过膜并进入靶细胞的胞质溶胶。 方法和相关组合物可用于治疗患有广泛病症（包括HIV感染）的患者; 癌症，如非霍奇金淋巴瘤和乳腺癌; 和血液学疾病，如严重的联合免疫缺陷。

    Site-specific incorporation of amino acids into molecules
    7.
    发明授权
    Site-specific incorporation of amino acids into molecules 有权
    位点特异性将氨基酸并入分子

    公开(公告)号：US08980581B2

    公开(公告)日：2015-03-17

    申请号：US13969368

    申请日：2013-08-16

    Applicant: California Institute of Technology

    Inventor： Pin Wang ,  Inchan Kwon ,  Soojin Son ,  Yi Tang ,  David Tirrell

    IPC: C12P21/02 ,  G01N33/68 ,  C12N9/00 ,  C12N15/67 ,  C12N15/70

    CPC classification number: C12N9/93 ,  C12N15/67 ,  C12N15/70

    Abstract: The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

    Abstract translation: 本发明提供了涉及将非天然氨基酸并入多肽或蛋白质的方法和组合物的某些实施方案，所述方法和组合物通过利用突变或修饰的氨酰-tRNA合成酶将非天然氨基酸加载至相应的tRNA。 在某些实施方案中，tRNA也被修饰，使得复合物与通常与未修饰的tRNA /氨酰-tRNA合成酶对形成摆动碱基配对的密码子形成严格的沃森 - 克里克碱基配对。

    SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES
    8.
    发明申请
    SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES 有权
    氨基酸进入分子的特定地点

    公开(公告)号：US20140045261A1

    公开(公告)日：2014-02-13

    申请号：US13969368

    申请日：2013-08-16

    Applicant: California Institute of Technology

    Inventor： Pin Wang ,  Inchan Kwon ,  Soojin Son ,  Yi Tang ,  David Tirrell

    IPC: C12N9/00 ,  C12N15/70

    CPC classification number: C12N9/93 ,  C12N15/67 ,  C12N15/70

    Abstract: The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.

    Abstract translation: 本发明提供了涉及将非天然氨基酸并入多肽或蛋白质的方法和组合物的某些实施方案，所述方法和组合物通过利用突变或修饰的氨酰-tRNA合成酶将非天然氨基酸加载至相应的tRNA。 在某些实施方案中，tRNA也被修饰，使得复合物与通常与未修饰的tRNA /氨酰-tRNA合成酶对形成摆动碱基配对的密码子形成严格的沃森 - 克里克碱基配对。

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