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    Inhibition of endosomal toll-like receptor activation
    2.
    发明授权
    Inhibition of endosomal toll-like receptor activation 有权

    公开(公告)号：US11617779B2

    公开(公告)日：2023-04-04

    申请号：US15291849

    申请日：2016-10-12

    Applicant: DUKE UNIVERSITY

    Inventor： Bruce A. Sullenger ,  Jaewoo Lee

    IPC: A61K38/16 ,  A61K38/17 ,  A61K31/70 ,  A61K31/13 ,  A61K31/722 ,  A61K31/785

    Abstract: The present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced activation of, for example, endosomal TLRs using an agent that binds to the nucleic acid (“nucleic acid binding agent”), preferably, in a manner that is independent of the nucleotide sequence, the chemistry (e.g., DNA or RNA, with or without base or sugar modifications) and/or the structure (e.g., double-stranded or single-stranded, complexed or uncomplexed with, for example protein) of the nucleic acid(s) responsible for inducing TLR activation. The invention also relates to methods of identifying nucleic acid binding agents suitable for use in such methods.

    2′ fluoro-modified RNAs as immunostimulators
    3.
    发明授权
    2′ fluoro-modified RNAs as immunostimulators 有权

    公开(公告)号：US10350158B2

    公开(公告)日：2019-07-16

    申请号：US15860248

    申请日：2018-01-02

    Applicant: DUKE UNIVERSITY

    Inventor： Jaewoo Lee ,  Johannes Urban ,  Bruce A. Sullenger

    IPC: C12N15/113 ,  C12N15/117 ,  A61K9/00 ,  C12N15/115 ,  A61K31/7115 ,  A61K9/127 ,  A61K39/00

    Abstract: Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine non-linear single stranded RNA at least 17 nucleotides long with a least 3 base pairings or a 5′ triphosphate, 2′ fluoro-modified double stranded RNA at least 17 base pairs long in an amount effective to inhibit cell growth, induce cell death or induce cytokine production by the cells. The methods also include administration of the compositions to a subject. The subject may have a proliferative disorder or infectious disease and administration of the compositions provided herein may treat the disorder or disease.

    REVERSIBLE PLATELET INHIBITION
    6.
    发明申请
    REVERSIBLE PLATELET INHIBITION 有权
    可逆板抑制

    公开(公告)号：US20160289297A1

    公开(公告)日：2016-10-06

    申请号：US14444431

    申请日：2014-07-28

    Applicant: DUKE UNIVERSITY

    Inventor： Bruce A. Sullenger ,  Shahid Nimjee ,  Sabah Oney ,  Nanette Que-Gewirth

    IPC: C07K14/705

    CPC classification number: C07K14/70557 ,  A61K31/7088 ,  A61K31/711 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/115 ,  C12N2310/113 ,  C12N2310/16 ,  C12N2310/322 ,  C12N2310/3533

    Abstract: The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits the activity of a receptor, such as glycoprotein IIb/IIIa (gpIIb/IIIa), and to aptamers suitable for use in such a method. The invention also relates to antidotes to antiplatelet agents and to methods of using such antidotes to reverse aptamer-induced platelet inhibition. The invention further relates to von Willebrand Factor (VWF) inhibitors, and antidotes therefore, and to methods of using same.

    Abstract translation: 本发明一般涉及受体和血小板聚集，特别涉及使用结合并抑制受体（例如糖蛋白IIb / IIIa（gpIIb / IIIa））的活性的适体抑制血小板聚集的方法 ）以及适用于这种方法的适体。 本发明还涉及抗血小板剂的解毒剂以及使用这种解毒剂来逆转适体诱导的血小板抑制的方法。 本发明还涉及血管性血友病因子（VWF）抑制剂和解毒剂，以及其使用方法。

    Compositions and methods for differential induction of cell death and interferon expression
    7.
    发明授权
    Compositions and methods for differential induction of cell death and interferon expression 有权

    公开(公告)号：US11613756B2

    公开(公告)日：2023-03-28

    申请号：US16499991

    申请日：2018-04-03

    Applicant: Duke University

    Inventor： Jaewoo Lee ,  Bruce A. Sullenger ,  Youngju Lee

    IPC: C12N15/117

    Abstract: Disclosed herein are compositions and methods for inhibiting the growth of cells or inducing cell death. The composition capable of inhibiting the growth of cells or inducing cell death comprises a 5′-triphosphate non-linear RNA. The RNA comprises a first stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and may optionally comprise a second stem-loop formed from the complete or partial hybridization of at least 8 nucleotide pairings and a spacer between the first stem-loop and the second stem loop. Methods for inhibiting the growth of cells or inducing cell death comprise contacting cells with the composition or administering the composition to a subject in an amount effective to inhibit the growth of the cells or induce death of the cells.

    Thrombus imaging aptamers and methods of using same
    8.
    发明授权
    Thrombus imaging aptamers and methods of using same 有权

    公开(公告)号：US11565002B2

    公开(公告)日：2023-01-31

    申请号：US16880791

    申请日：2020-05-21

    Applicant: Duke University

    Inventor： Bruce A. Sullenger ,  Kady-Ann C. Steen-Burrell ,  Bethany Powell Gray

    IPC: A61K49/00 ,  C12N15/115 ,  C07H21/02

    Abstract: Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to diagnose and treat thrombosis. The imaging agents include an aptamer capable of binding the thrombus or thrombin in particular linked to a reporter moiety. The imaging agents may be used to label the thrombus or sites of thrombin accumulation. Antidotes capable of binding to the aptamer in the imaging agent are also provided. The antidotes may further be linked to a quencher capable of quenching the reporter moiety.

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