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    Enhanced aerosol test for assessing filter integrity
    3.
    发明授权
    Enhanced aerosol test for assessing filter integrity 有权

    公开(公告)号：US10119897B2

    公开(公告)日：2018-11-06

    申请号：US15057641

    申请日：2016-03-01

    Applicant: EMD Millipore Corporation

    Inventor： Salvatore Giglia ,  David Nhiem ,  Gabriel Tkacik

    IPC: G01N15/08 ,  B01D65/10 ,  G01M3/20

    Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 μm in diameter, and even as small as 2 μm in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.

    Enhanced Aerosol Test For Assessing Filter Integrity
    4.
    发明申请
    Enhanced Aerosol Test For Assessing Filter Integrity 审中-公开
    用于评估过滤器完整性的增强型气溶胶测试

    公开(公告)号：US20160299048A1

    公开(公告)日：2016-10-13

    申请号：US15057641

    申请日：2016-03-01

    Applicant: EMD Millipore Corporation

    Inventor： Salvatore Giglia ,  David Nhiem ,  Gabriel Tkacik

    IPC: G01N15/08

    CPC classification number: G01N15/088 ,  B01D65/102 ,  B01D2273/18 ,  G01M3/20 ,  G01N15/0826 ,  G01N2015/084 ,  G01N2015/0846

    Abstract: A method of aerosol integrity testing of filters, capable of detecting single defects that are less than 20 μm in diameter, and even as small as 2 μm in diameter, in liquid sterilizing grade filters such as filter cartridges. The method challenges the filter in a dry state with a particle stream of aerosol particles of the appropriate size and in the appropriate concentration, such that at least one or more of the particles in the stream will penetrate a defective region or regions within the membrane but will not penetrate in the integral region of the membrane. Wetting of the filter is not required.

    Abstract translation: 一种过滤器的气溶胶完整性测试方法，能够检测液体杀菌级过滤器（如过滤器滤芯）中直径小于20μm，直径小至2μm的单一缺陷。 该方法在干燥状态下用适当尺寸和适当浓度的气溶胶颗粒的颗粒流挑战过滤器，使得流中的至少一种或多种颗粒将渗透膜内的缺陷区域或区域，但 不会渗入膜的整体区域。 不需要过滤器的润湿。

    Ultraporous Nanofiber Mats And Uses Thereof
    5.
    发明申请
    Ultraporous Nanofiber Mats And Uses Thereof 审中-公开
    超声波纳米纤维垫及其用途

    公开(公告)号：US20150298070A1

    公开(公告)日：2015-10-22

    申请号：US14648925

    申请日：2013-12-10

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： Mikhail Koslov ,  Gabriel Tkacik ,  Onur Y. Kas ,  Ajish Potty ,  Jigneshkumar Patel

    IPC: B01D71/56 ,  B01D69/06 ,  B01D61/14

    CPC classification number: B01D71/56 ,  A61L2/022 ,  B01D39/1623 ,  B01D61/145 ,  B01D67/0004 ,  B01D69/06 ,  B01D2239/025 ,  B01D2239/0631 ,  B01D2239/0654 ,  B01D2239/1233 ,  B01D2323/39

    Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 um to about 0.03 um, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 um to about 100 um, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electro-spun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.

    Abstract translation: 用于从流体流中除去病毒颗粒（例如细小病毒）和其他颗粒的多孔电纺聚合物纳米纤维液体过滤介质，例如电纺丝垫，其具有测量的平均流动泡点 全氟己烷高于100psi。 电纺介质包括平均纤维直径为约6nm至约13nm的纳米纤维，纳米纤维液体过滤介质的平均孔径为约0.01μm至约0.03μm，孔隙率为约80％至约95 ％，约1μm至约100μm的厚度，以及大于约10LHH / psi的液体渗透性。 电纺垫的高孔隙度使得能够获得更高的水通量，从而减少在流体流上完成病毒过滤步骤所需的时间。

    ULTRAPOROUS NANOFIBER MATS AND USES THEREOF
    7.
    发明申请
    ULTRAPOROUS NANOFIBER MATS AND USES THEREOF 有权

    公开(公告)号：US20230123639A1

    公开(公告)日：2023-04-20

    申请号：US18066610

    申请日：2022-12-15

    Applicant: EMD Millipore Corporation

    Inventor： Mikhail Kozlov ,  Gabriel Tkacik ,  Onur Y. Kas ,  Ajish Potty ,  Jigneshkumar Patel

    IPC: B01D71/56 ,  B01D61/14 ,  B01D69/06 ,  B01D67/00 ,  B01D39/16 ,  A61L2/02

    Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 μm to about 0.03 μm, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 μm to about 100 μm, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.

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