公开(公告)号：US20230167419A1

公开(公告)日：2023-06-01

申请号：US17818038

申请日：2022-08-08

Applicant: Genomatica, Inc.

Inventor： Baolong ZHU ,  Andreas W. Schirmer ,  Cindy Chang

IPC: C12N9/02 ,  C12P7/6409

CPC classification number: C12N9/0077 ,  C12P7/6409

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for ex pressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US11142756B2

公开(公告)日：2021-10-12

申请号：US16802133

申请日：2020-02-26

Applicant: Genomatica, Inc.

Inventor： Derek L. Greenfield ,  Donald E. Trimbur ,  Andreas W. Schirmer ,  Cindy Chang ,  Behnaz Behrouzian ,  Jessica Winger

IPC: C12N15/63 ,  C12N15/70 ,  C12N9/88 ,  C12N1/21 ,  C07K14/245 ,  C12P7/64 ,  C12N9/00 ,  C12N15/67

Abstract: The disclosure relates to acetyl-CoA carboxylase (ACC) variants and host cells expressing them for the production of malonyl-CoA derived compounds including fatty acid derivatives. Further contemplated are methods of producing increased amounts of malonyl-CoA derived compounds and related cell cultures.

公开(公告)号：US11441130B2

公开(公告)日：2022-09-13

申请号：US15319272

申请日：2015-06-16

Applicant: GENOMATICA, INC.

Inventor： Baolong Zhu ,  Andreas W. Schirmer ,  Cindy Chang

IPC: C12N9/02 ,  C12P7/6409

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

公开(公告)号：US20210071212A1

公开(公告)日：2021-03-11

申请号：US16915454

申请日：2020-06-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N9/02 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52 ,  C12N9/04

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US10711288B2

公开(公告)日：2020-07-14

申请号：US14897285

申请日：2014-06-16

Applicant: GENOMATICA, INC.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/64 ,  C12N1/21 ,  C12N9/04 ,  C12N9/02 ,  C12N9/88 ,  C12N9/10 ,  C12N9/06 ,  C12N15/53 ,  C12N15/54 ,  C12N9/60 ,  C07K19/00 ,  C12P7/42 ,  C12N15/62 ,  C12P7/18 ,  C12N15/52

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US11981952B2

公开(公告)日：2024-05-14

申请号：US16915454

申请日：2020-06-29

Applicant: Genomatica, Inc.

Inventor： Andreas W. Schirmer ,  Haibo Wang ,  Stephen B. Del Cardayre ,  Zhihao Hu ,  Louis G. Hom ,  Baolong Zhu ,  Cindy Chang ,  Emanuela E. Popova

IPC: C12P7/6409 ,  C12N1/21 ,  C12N9/02 ,  C12N9/04 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436

CPC classification number: C12P7/6409 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/0071 ,  C12N9/0077 ,  C12N15/52 ,  C12N15/62 ,  C12P7/18 ,  C12P7/42 ,  C12P7/6436 ,  C12Y114/14001 ,  C12Y114/15003 ,  C07K2319/00 ,  C12Y101/00 ,  C12Y102/01042 ,  Y02E50/10

Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

公开(公告)号：US11421206B2

公开(公告)日：2022-08-23

申请号：US16661667

申请日：2019-10-23

Applicant: Genomatica, Inc.

Inventor： Baolong Zhu ,  Andreas W. Schirmer ,  Cindy Chang

IPC: C12N9/02 ,  C12N15/62 ,  C12P7/6409

Abstract: The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.