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公开(公告)号：US10941454B2
公开(公告)日：2021-03-09
申请号：US15578488
申请日：2016-05-26
Applicant: GENOMATICA, INC. , BRASKEM S.A.
Inventor： Stephanie J. Culler , Robert J. Haselbeck , Harish Nagarajan , Iuri Estrada Gouvea , Daniel Johannes Koch , Mateus Schreiner Garcez Lopes , Lucas Pedersen Parizzi
Abstract: In alternative embodiments, provided are non-natural or genetically engineered vinylisomerase-dehydratase enzymes, including alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases. In alternative embodiments, provided are non-natural or genetically engineered polypeptides having an activity comprising, for example, a vinylisomerase-dehydratase, an alkenol dehydratase, a linalool dehydratase and/or a crotyl alcohol dehydratase activity, or a combination thereof. In alternative embodiments, also provided are non-natural or genetically engineered nucleic acids (polynucleotides) encoding polypeptides described herein, expression or cloning vehicles comprising or having contained therein nucleic acids as described herein, and non-natural or genetically engineered cells comprising or having contained therein nucleic acids as described herein. In alternative embodiments, also provided are methods for making various organic compounds, including methyl vinyl carbinol and butadiene.
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2.发明申请公开(公告)号：US20210371622A1
公开(公告)日：2021-12-02
申请号：US17333317
申请日：2021-05-28
Applicant: Braskem S.A.
Inventor： Felipe Cicaroni Fernandes , Iuri Estrada Gouvea , Antonio Rodolfo, JR. , Mateus Schreiner Garcez Lopes
IPC: C08K5/1535 , C08K5/00 , C08L27/06 , C08J3/18 , C08J3/12 , C07D307/68
Abstract: The present disclosure generally relates to a compound of dialkyl ester of 2,4-furandicarboxylic acid, a method of preparing the compound, a polymer composition comprising a polymer and the compound, a method of preparing the polymer composition, a polymer product comprising the polymer composition and a method of using the compound as a plasticizer in the polymer product. The dialkyl ester of 2,4-furandicarboxylic acid of the present disclosure has greater plasticizing efficiency in a polymer composition that that of the standard phthalate and terephthalate-based plasticizers. The polymer product plasticized with the dialkyl ester of 2,4-furandicarboxylic acid may have improved flexibility, durability, processability and safety as compared to the same polymer product plasticized with conventional phthalate and terephthalate-based plasticizers.
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公开(公告)号：US20150240264A1
公开(公告)日：2015-08-27
申请号：US14627205
申请日：2015-02-20
Applicant: BRASKEM S.A.
Abstract: The present disclosure generally relates to microorganisms (e.g., non-naturally occurring microorganisms) that comprise one or more polynucleotides coding for enzymes in a pathway that catalyze a conversion of a carbon source (e.g., a fermentable carbon source) to terpene, succinate, and hydrogen and the use of such microorganisms for the production of terpene, succinate, and hydrogen.
Abstract translation: 本公开内容通常涉及包含一种或多种编码催化碳源（例如可发酵碳源）转化为萜烯，琥珀酸酯和 氢和使用这些微生物来生产萜烯，琥珀酸和氢。
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公开(公告)号：US20150211024A1
公开(公告)日：2015-07-30
申请号：US14423787
申请日：2013-08-28
Applicant: Braskem S.A.
Inventor： Mateus Schreiner Garcez Lopes , Avram Michael Slovic
Abstract: The present disclosure generally relates to microorganisms (e.g., non-naturally occurring microorganisms) that comprise one or more polynucleotides coding for enzymes in a pathway that catalyze a conversion of a carbon source (e.g., a fermentable carbon source) to terpene and a co-product such as succinate, 1,3-butanediol, or crotonyl alcohol and the use of such microorganisms for the production of terpene and a co-product such as succinate, 1,3-butanediol, or crotonyl alcohol.
Abstract translation: 本公开一般涉及包含一种或多种编码酶的多核苷酸的微生物（例如非天然存在的微生物），所述多核苷酸在催化碳源（例如，可发酵碳源）转化为萜烯的途径中， 产品如琥珀酸酯，1,3-丁二醇或巴豆醇，以及这些微生物用于生产萜烯和共产物如琥珀酸酯，1,3-丁二醇或巴豆醇的用途。
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5.发明申请MODIFIED MICROORGANISM AND METHODS OF USING SAME FOR PRODUCING BUTADIENE AND 1-PROPANOL AND/OR 1,2-PROPANEDIOL 审中-公开改良的微生物及其生产丁二酸和1-丙醇和/或1,2-丙二醇的方法公开(公告)号：US20150064760A1
公开(公告)日：2015-03-05
申请号：US14479071
申请日：2014-09-05
Applicant: BRASKEM S.A.
Inventor： Johana Rincones Perez , Juan Diego Rojas Rojas , Ane Fernanda Beraldi Zeidler , Aline Silva Romao Dumaresq , Marilene Elizabete Pavan Rodrigues , Iuri Estrada Gouvea , Felipe Galzerani , Daniel Johannes Koch , Lucas Pedersen Parizzi , Mateus Schreiner Garcez Lopes , Thomas Martin Halder , Antonio Luis Ribeiro De Castro Morschbacker , Avram Michael Slovic
CPC classification number: C12P7/18 , C07K14/395 , C12N15/63 , C12P5/026 , C12P7/04
Abstract: The present disclosure provides a non-naturally occurring microorganism comprising: one or more polynucleotides encoding one or more enzymes in a pathway that produces acetyl-CoA; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of crotonyl alcohol, 5-hydroxy-3-ketovaleryl-CoA, 3-ketopent-4-enoyl-CoA, or 3,5-ketovaleryl-CoA to butadiene; one or more polynucleotides encoding one or more enzymes in a pathway that catalyze a conversion of dihydroxyacetone-phosphate to 1-propanol and/or 1,2-propanediol, wherein the microorganism has reduced levels of pyruvate decarboxylase enzymatic activity (e.g., the microorganism comprises a disruption of one or more enzymes that decarboxylate pyruvate and/or a disruption of one or more transcription factors of one or more enzymes that decarboxylate pyruvate), and wherein the microorganism is capable of growing on a C6 sugar as a sole carbon source under anaerobic conditions. Also provided are methods of using the disclosed non-naturally occurring microorganisms in methods for the coproduction of butadiene and 1-propanol and/or 1,2-propanediol.
Abstract translation: 本公开提供了非天然存在的微生物，其包含：在产生乙酰辅酶A的途径中编码一种或多种酶的一种或多种多核苷酸; 在催化巴豆醇，5-羟基-3-酮戊酰基-CoA，3-酮戊-4-烯酰基-CoA或3,5-酮戊酰基-CoA转化为丁二烯的途径中编码一种或多种酶的一种或多种多核苷酸 ; 一种或多种编码一种或多种酶的多核苷酸，其在催化二羟丙基磷酸盐转化为1-丙醇和/或1,2-丙二醇的途径中，其中微生物具有降低的丙酮酸脱羧酶水平的酶活性（例如，微生物包含 破坏一种或多种脱羧酸丙酮酸酶和/或破坏一种或多种丙酮酸脱羧酸酶的一种或多种转录因子的酶），并且其中所述微生物能够生长在C6糖作为唯一碳源的厌氧 条件。 还提供了在共同生产丁二烯和1-丙醇和/或1,2-丙二醇的方法中使用所公开的非天然存在的微生物的方法。
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Patent Agency Ranking
6.发明授权公开(公告)号：US12163008B2
公开(公告)日：2024-12-10
申请号：US17333317
申请日：2021-05-28
Applicant: Braskem S.A.
Inventor： Felipe Cicaroni Fernandes , Iuri Estrada Gouvea , Antonio Rodolfo, Jr. , Mateus Schreiner Garcez Lopes
IPC: C07D307/68 , C08J3/12 , C08J3/18 , C08K5/00 , C08K5/1535 , C08L27/06
Abstract: The present disclosure generally relates to a compound of dialkyl ester of 2,4-furandicarboxylic acid, a method of preparing the compound, a polymer composition comprising a polymer and the compound, a method of preparing the polymer composition, a polymer product comprising the polymer composition and a method of using the compound as a plasticizer in the polymer product. The dialkyl ester of 2,4-furandicarboxylic acid of the present disclosure has greater plasticizing efficiency in a polymer composition that that of the standard phthalate and terephthalate-based plasticizers. The polymer product plasticized with the dialkyl ester of 2,4-furandicarboxylic acid may have improved flexibility, durability, processability and safety as compared to the same polymer product plasticized with conventional phthalate and terephthalate-based plasticizers.
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7.发明申请MODIFIED MICROORGANISMS AND METHODS OF CO-PRODUCING BUTADIENE WITH 1-PROPANOL AND/OR 1,2-PROPANEDIOL 审中-公开与1,2-丙醇和/或1,2-丙二醇共同生产丁二烯的改性微生物和方法公开(公告)号：US20150152440A1
公开(公告)日：2015-06-04
申请号：US14409292
申请日：2013-06-18
Applicant: Braskem S.A.
Inventor： Mateus Schreiner Garcez Lopes , Avram Michael Slovic , Paulo Luiz de Andrade Coutinho , Antonio Luiz Ribeiro De Castro Morschbacker
CPC classification number: C12P5/026 , C12N15/63 , C12P7/04 , C12P7/18 , C12P2203/00
Abstract: The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in a pathway that catalyzes a conversion of a fermentable carbon source to butadiene and/or one or more polynucleotides coding for enzymes in a pathway that catalyzes a conversion of a fermentable carbon source to 1-propanol and/or 1,2-propanadiol. Also provided are methods of using the microorganisms to produce butadiene and co-products such 1-propanol and/or 1,2-propanediol.
Abstract translation: 本公开内容通常涉及包含一种或多种编码酶的多核苷酸的微生物，所述多核苷酸在催化可发酵碳源转化为丁二烯的途径中和/或一种或多种编码催化转化可发酵的途径中的酶的多核苷酸 碳源至1-丙醇和/或1,2-丙二醇。 还提供了使用微生物来生产丁二烯和副产物如1-丙醇和/或1,2-丙二醇的方法。
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公开(公告)号：US20180346936A1
公开(公告)日：2018-12-06
申请号：US16042594
申请日：2018-07-23
Applicant: Braskem S.A.
Inventor： Mateus Schreiner Garcez Lopes , Avram Michael Slovic , Iuri Estrada Gouvea , Johana Rincones Perez , Lucas Pedersen Parizzi
CPC classification number: C12P5/026 , C12N9/88 , C12N15/52 , C12P5/02 , C12Y402/01127
Abstract: The present disclosure generally relates to methods of using microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene and products and processes derived therefrom.
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公开(公告)号：US20160032325A1
公开(公告)日：2016-02-04
申请号：US14885311
申请日：2015-10-16
Applicant: Braskem S.A.
Inventor： Mateus Schreiner Garcez Lopes , Avram Michael Slovic , Iuri Estrada Gouvea , Johana Rincones Perez , Lucas Pedersen Parizzi
CPC classification number: C12P5/026 , C12N9/88 , C12N15/52 , C12P5/02 , C12Y402/01127
Abstract: The present disclosure generally relates to microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene. Also provided are methods of using the microorganisms in industrial processes including, for use in the production of butadiene and products derived therefrom.
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公开(公告)号：US10273505B2
公开(公告)日：2019-04-30
申请号：US16042594
申请日：2018-07-23
Applicant: Braskem S.A.
Inventor： Mateus Schreiner Garcez Lopes , Avram Michael Slovic , Iuri Estrada Gouvea , Johana Rincones Perez , Lucas Pedersen Parizzi
Abstract: The present disclosure generally relates to methods of using microorganisms that comprise one or more polynucleotides coding for enzymes in one or more pathways that catalyze a conversion of a fermentable carbon source to butadiene and products and processes derived therefrom.
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