公开(公告)号：US20190016749A1

公开(公告)日：2019-01-17

申请号：US16016369

申请日：2018-06-22

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke

IPC: C07H19/23 ,  A61K45/06 ,  C07H19/12 ,  A61K31/706

Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

公开(公告)号：US20180016280A1

公开(公告)日：2018-01-18

申请号：US15610104

申请日：2017-05-31

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07D487/04 ,  C07F9/6561 ,  C07D405/14 ,  C07H7/06 ,  C07D405/04

CPC classification number: C07D487/04 ,  C07D405/04 ,  C07D405/14 ,  C07F9/6561 ,  C07H7/06

Abstract: Provided herein are formulations, methods and substituted tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of tetrahydrofuranyl-pyrrolo[1,2-f][1,2,4]triazine-4-amine compounds.

公开(公告)号：US20170114086A1

公开(公告)日：2017-04-27

申请号：US15282492

申请日：2016-09-30

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke

IPC: C07H19/23

CPC classification number: C07H19/23 ,  A61K31/706 ,  A61K45/06 ,  C07H19/12

Abstract: Provided are compounds of Formula I, as well as pharmaceutical compositions containing compounds of Formula I and methods for treating Orthomyxoviridae virus infections by administering these compounds. The compounds, compositions, and methods provided are particularly useful for the treatment of Human Influenza virus infections.

公开(公告)号：US20160122374A1

公开(公告)日：2016-05-05

申请号：US14926062

申请日：2015-10-29

Applicant: Gilead Sciences, Inc.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/685

CPC classification number: A61K31/685 ,  A61K31/00 ,  A61K31/53 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00 ,  C07F9/2429 ,  C07F9/65616 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K2300/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Abstract translation: 本发明提供了通过给予式IV的核糖苷，核苷磷酸酯及其前体药物治疗丝状病毒感染的化合物，方法和药物组合物：所提供的化合物，组合物和方法特别可用于治疗马尔堡病毒，埃博拉病毒和Cueva 病毒感染。

公开(公告)号：US11266666B2

公开(公告)日：2022-03-08

申请号：US16881419

申请日：2020-05-22

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/706 ,  A61K31/7056 ,  A61K31/685 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20210052613A1

公开(公告)日：2021-02-25

申请号：US16881419

申请日：2020-05-22

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/706 ,  A61K31/7056 ,  A61K31/53 ,  C07H1/00 ,  C07H1/02 ,  C07H11/00 ,  C07H15/18 ,  A61K31/6615 ,  A61K31/665 ,  A61K31/683 ,  C07D487/04 ,  C07D519/00 ,  C07F9/24 ,  C07F9/6561 ,  A61K31/675 ,  A61K45/06 ,  A61K31/00

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20190275063A1

公开(公告)日：2019-09-12

申请号：US16274049

申请日：2019-02-12

Applicant: GILEAD SCIENCES, INC.

Inventor： Byoung Kwon Chun ,  Michael O' Neil Hanrahan Clarke ,  Edward Doerffler ,  Hon Chung Hui ,  Robert Jordan ,  Richard L. Mackman ,  Jay P. Parrish ,  Adrian S. Ray ,  Dustin Siegel

IPC: A61K31/685 ,  A61K31/683 ,  A61K31/706 ,  A61K31/6615 ,  C07H15/18 ,  C07H11/00 ,  C07H1/02 ,  C07H1/00 ,  A61K31/53 ,  A61K31/675 ,  C07F9/6561 ,  C07F9/24 ,  C07D519/00 ,  C07D487/04 ,  A61K31/00 ,  A61K45/06 ,  A61K31/7056 ,  A61K31/665

Abstract: Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

公开(公告)号：US20200157137A1

公开(公告)日：2020-05-21

申请号：US16454536

申请日：2019-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/073 ,  A61K31/7068 ,  A61K31/7072

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20170327526A1

公开(公告)日：2017-11-16

申请号：US15441561

申请日：2017-02-24

Applicant: Gilead Sciences, Inc.

Inventor： Michael O' Neil Hanrahan Clarke ,  Richard L. Mackman ,  Dustin Siegel

IPC: C07H19/06 ,  C07H19/10 ,  C07H19/073

CPC classification number: C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  C07H19/073 ,  C07H19/10

Abstract: Provided herein are formulations, methods and substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae virus infections, including respiratory syncytial virus infections, as well as methods and intermediates for synthesis of substituted 2′-chloro aminopyrimidinone and pyrimidine dione compounds.

公开(公告)号：US20160016980A1

公开(公告)日：2016-01-21

申请号：US14746430

申请日：2015-06-22

Applicant: Gilead Sciences, Inc.

Inventor： Aesop Cho ,  Michael O' Neil Hanrahan Clarke ,  Scott Alan Wolckenhauer

IPC: C07F9/24

CPC classification number: C07H1/00 ,  A61K31/7042 ,  A61K31/7052 ,  C07F9/2458 ,  C07F9/65586 ,  C07F9/6561 ,  C07F9/65616 ,  C07H19/02 ,  C07H19/10 ,  C07H19/20

Abstract: Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib: The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.