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公开(公告)号：US11708394B2
公开(公告)日：2023-07-25
申请号：US17265610
申请日：2019-08-09
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Maria Scarselli , Daniele Veggi
IPC: C07K14/22 , A61P31/04 , A61K39/095
CPC classification number: C07K14/22 , A61K39/095 , A61P31/04 , C07K2319/00
Abstract: The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.
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公开(公告)号：US10328140B2
公开(公告)日：2019-06-25
申请号：US15127537
申请日：2015-03-24
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Fabio Bagnoli , Luigi Fiaschi , Maria Scarselli
IPC: A61K39/085 , A61K39/00 , A61K49/00 , C07K14/31
Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.
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公开(公告)号：US09764020B2
公开(公告)日：2017-09-19
申请号：US15050107
申请日：2016-02-22
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC: A61K39/085 , C07K14/31 , A61K39/00
CPC classification number: A61K39/085 , A61K2039/70 , C07K14/31
Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US09694063B2
公开(公告)日：2017-07-04
申请号：US14363387
申请日：2012-12-07
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Maria Scarselli , Mariagrazia Pizza , Rosanna Leuzzi , Maria Arico , Manuele Martinelli , Gillian Douce
CPC classification number: A61K39/08 , A61K2039/55505 , A61K2039/55566 , A61K2039/70 , C07K14/33 , C07K2319/20
Abstract: The present invention relates to recombinant fragments of C. difficile TcdA and TcdB that may be used in the development of vaccines against C. difficile associated disease. More particularly it relates to combinations comprising a ToxB-GT antigen and a TcdA antigen or a ToxA-GT antigen and a TcdB antigen.
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公开(公告)号：US09249198B2
公开(公告)日：2016-02-02
申请号：US14450082
申请日：2014-08-01
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC classification number: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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Patent Agency Ranking
公开(公告)号：US11021522B2
公开(公告)日：2021-06-01
申请号：US16458365
申请日：2019-07-01
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew Bottomley , Enrico Malito , Manuele Martinelli , Maria Scarselli
IPC: A61P37/04 , C07K14/22 , A61K39/095 , A61K39/00
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US10392424B2
公开(公告)日：2019-08-27
申请号：US15120674
申请日：2015-02-27
Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
Inventor： Matthew Bottomley , Enrico Malito , Manuele Martinelli , Maria Scarselli
IPC: A61K39/095 , C07K14/22 , A61K39/00
Abstract: Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US10226524B2
公开(公告)日：2019-03-12
申请号：US15679910
申请日：2017-08-17
Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA
Inventor： Vega Masignani , Marirosa Mora , Maria Scarselli
IPC: A61K39/085 , C07K14/31 , A61K39/00
Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
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公开(公告)号：US09642904B2
公开(公告)日：2017-05-09
申请号：US14961772
申请日：2015-12-07
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Fabio Bagnoli , Massimiliano Biagini , Luigi Fiaschi , Guido Grandi , Ravi Pratap Narayan Mishra , Nathalie Norais , Maria Scarselli
IPC: A61K39/085 , C07K14/31 , A61K39/00
CPC classification number: A61K39/085 , A61K39/00 , C07K14/31 , C07K2319/00
Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
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公开(公告)号：US09266929B2
公开(公告)日：2016-02-23
申请号：US14450075
申请日：2014-08-01
Applicant: GlaxoSmithKline Biologicals SA
Inventor： Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC: C12P21/00 , C12N15/00 , C12N15/09 , C07K14/22 , A61K39/095
CPC classification number: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
Abstract: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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