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公开(公告)号：US12030926B2
公开(公告)日：2024-07-09
申请号：US17171962
申请日：2021-02-09
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Whitney Shatz , Domingos Ng
CPC classification number: C07K16/00 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/53 , C12N15/79 , C12N15/907
Abstract: Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes located on a single molecule or located on different molecules.
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公开(公告)号：US11155591B2
公开(公告)日：2021-10-26
申请号：US16196829
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Eric Gary Stefanich , Richard Vandlen , Philip E. Hass , Xiaoting Wang
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190233491A1
公开(公告)日：2019-08-01
申请号：US16128008
申请日：2018-09-11
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
CPC classification number: C07K14/54 , A61K38/00 , A61K38/20 , A61K47/38 , C07K16/2866 , C07K2319/30
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US09862778B2
公开(公告)日：2018-01-09
申请号：US14251428
申请日：2014-04-11
Applicant: Genentech, Inc.
Inventor： Glen Giese , Amy Lim , Josefine Persson , Justin Scheer , Ambrose Williams
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622
Abstract: Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.
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公开(公告)号：US11192950B2
公开(公告)日：2021-12-07
申请号：US16395009
申请日：2019-04-25
Applicant: Genentech, Inc.
Inventor： Isidro Hotzel , Teemu T. Junttila , Ji Li , Justin Scheer , Danielle Dicara , Diego Ellerman , Christoph Spiess , Paul J. Carter
IPC: C07H21/02 , C07H21/04 , C12P21/06 , C12P21/04 , C12N5/00 , C12N5/16 , C12N1/20 , C07K16/28 , A61K47/68 , A61K39/395 , A61K45/06 , C07K16/30 , G01N33/574 , C07K16/00 , A61K39/00
Abstract: The present invention relates to anti-FcRH5 antibodies, including anti-FcRH5 antibodies comprising an FcRH5 binding domain and a CD3 binding domain (e.g., FcRH5 T cell-dependent bispecific (TDB) antibodies), and methods of using the same.
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Patent Agency Ranking
公开(公告)号：US10584155B2
公开(公告)日：2020-03-10
申请号：US15801867
申请日：2017-11-02
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US20190177387A1
公开(公告)日：2019-06-13
申请号：US16196743
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Ganesh A. Kolumam , Xiaoting Wang , Jed Ross , Nicholas Van Bruggen , Wyne P. Lee
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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公开(公告)号：US10160793B2
公开(公告)日：2018-12-25
申请号：US14214161
申请日：2014-03-14
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Richard Vandlen , Philip E. Hass , Eric Gary Stefanich , Xiaoting Wang
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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9.发明申请公开(公告)号：US20180293360A1
公开(公告)日：2018-10-11
申请号：US15766319
申请日：2016-10-05
Applicant: Genentech, Inc.
Inventor： Robert Kelley , Justin Scheer , Whitney Shatz
Abstract: Disclosed are systems and methods for estimating the vitreal half-life of a therapeutic agent. In particular, systems and methods are disclosed for predicting the vitreal half-life of a therapeutic agent conjugated to a polymer that make use of an empirically-derived relationship of vitreal half-life to the hydrodynamic radius of a candidate therapeutic agent-polymer conjugate. The present disclosure is further directed to the use of the systems and methods disclosed herein to design a candidate therapeutic agent-polymer conjugate with a preselected vitreal half-life.
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公开(公告)号：US11130791B2
公开(公告)日：2021-09-28
申请号：US16196936
申请日：2018-11-20
Applicant: Genentech, Inc.
Inventor： Justin Scheer , Wenjun Ouyang , Eric Gary Stefanich , Richard Vandlen , Philip E. Hass , Xiaoting Wang
Abstract: The invention relates to IL-22 polypeptides, IL-22 Fc fusion proteins and IL-22 agonists, composition comprising the same, methods of making and methods of using the composition for the treatment of diseases. The invention also relates to IL-22 receptor associated reagents and methods of use thereof.
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