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17 条记录 (耗时 0.03 秒)

    Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
    8.
    发明授权
    Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders 失效
    用于治疗癌症，代谢疾病和皮肤病症的治疗剂

    公开(公告)号：US07572816B2

    公开(公告)日：2009-08-11

    申请号：US10514383

    申请日：2004-07-21

    申请人： Bruno Tse ,  Sepehr Sarshar

    发明人： Bruno Tse ,  Sepehr Sarshar

    IPC分类号： A61K31/47 ,  A61K31/425 ,  A61K31/415 ,  C07D295/00 ,  C07D207/00 ,  C07D401/00 ,  C07D233/00 ,  C07D277/00 ,  C07D409/00 ,  C07D403/00 ,  C07D239/02 ,  C07D215/02 ,  C07D271/00 ,  C07D285/02 ,  C07D257/04 ,  C07D487/00

    CPC分类号： C07D233/72 ,  C07D277/34

    摘要： The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders in mammalian subjects. These compounds are also useful modulators of gene expression. They exert their activity by interfering with certain cellular signal transduction cascades. The compounds of the invention are thus also useful for regulating cell differentiation and cell cycle processes that are controlled or regulated by various hormones or cytokines. In particular, the invention relates to compounds that induce apoptosis of cancer cells and therefore may be used for the treatment or prevention of cancer, including advanced cancers and pre-cancerous cells. The invention also discloses pharmaceutical compositions and methods of treatment of disease in mammals

    摘要翻译： 本发明涉及具有其中R 1，R 2，R 3，R 4，R 5和m如本文所定义的结构的化合物。 本发明的化合物是用于治疗哺乳动物受试者的癌症，代谢疾病和皮肤病症的新型治疗剂。 这些化合物也是基因表达的有用调节剂。 它们通过干扰某些细胞信号转导级联发挥其活性。 因此，本发明的化合物也可用于调节由各种激素或细胞因子控制或调节的细胞分化和细胞周期过程。 特别地，本发明涉及诱导癌细胞凋亡的化合物，因此可用于治疗或预防癌症，包括晚期癌症和癌前细胞。 本发明还公开了哺乳动物疾病的药物组合物和治疗方法

    Enterobactin compounds
    9.
    发明授权
    Enterobactin compounds 失效
    肠易激蛋白化合物

    公开(公告)号：US5412080A

    公开(公告)日：1995-05-02

    申请号：US111622

    申请日：1993-08-25

    申请人： Yoshito Kishi ,  Bruno Tse

    发明人： Yoshito Kishi ,  Bruno Tse

    IPC分类号： C07D493/18 ,  C07H15/00 ,  C07H17/00 ,  C07H17/02

    CPC分类号： C07D493/18

    摘要： Enterobactin analogs prepared from scyllo-inositol mono-orthoformate and having the following formula: ##STR1## wherein each X.sub.1, X.sub.2 and X.sub.3, independently, is H, C.sub.1-20 alkyl, phenyl, naphthyl, C.sub.7-20 aralkyl, or C.sub.7-20 alkaryl; Y is H, C.sub.1-20 alkyl, phenyl, naphthyl; C.sub.7-20 aralkyl, C.sub.7-20 alkaryl; --(C.sub.p H.sub.2p)--CH.sub.2 OH, --(C.sub.p H.sub.2p)--COOH or its salt, --(C.sub.p H.sub.2p)--NR.sub.1.R.sub.2 or its salt, or --(C.sub.p H.sub.2p)--N.sup.+ R.sub.1.R.sub.2.R.sub.3 ; in which p is 1-20 and each R.sub.1, R.sub.2 and R.sub.3, independently, is H or C.sub.1-5 alkyl; and m, n and o, independently, is 1-6; or the enantiomer thereof.

    摘要翻译： 由鲨肌醇单原甲酸酯制备的具有下列结构式的生物激素类似物：其中每个X1，X2和X3独立地为H，C1-20烷基，苯基，萘基，C7-20芳烷基或C7-20 烷芳基 Y是H，C 1-20烷基，苯基，萘基; C7-20芳烷基，C7-20烷芳基; - （CpH2p）-CH2OH， - （CpH2p）-COOH或其盐， - （CpH2p）-NR1R2或其盐，或 - （CpH2p）-N + R1.R2R3; 其中p为1-20，且每个R 1，R 2和R 3独立地为H或C 1-5烷基; m，n和o独立地为1-6; 或其对映异构体。