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    Substituted heterocyclic compounds and methods of use
    1.
    发明申请
    Substituted heterocyclic compounds and methods of use 失效
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050026914A1

    公开(公告)日：2005-02-03

    申请号：US10891636

    申请日：2004-07-13

    申请人： John Buchanan ,  Daniel Elbaum ,  Matthew Martin ,  David McGowan ,  Perry Novak ,  Joseph Nunes

    发明人： John Buchanan ,  Daniel Elbaum ,  Matthew Martin ,  David McGowan ,  Perry Novak ,  Joseph Nunes

    IPC分类号： A61P37/00 ,  C07D213/75 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/541 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02 ,  C07

    CPC分类号： C04B35/632 ,  C07D213/75 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

    摘要： The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.

    摘要翻译： 本发明涉及具有通式I的嘧啶或吡啶氨基甲酸酯化合物及其药学上可接受的盐或衍生物。 还包括治疗各种疾病和病症的方法，包括炎症，T细胞活化和增殖的抑制，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮， 超敏反应，1型糖尿病，牛皮癣，皮炎，桥本甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹，癌症，结肠癌，胸腺瘤，仅举几例 哺乳动物，所述方法包括给予治疗有效量的如上所述的式I化合物或其盐或衍生物形式。

    Substituted heterocyclic compounds and methods of use
    3.
    发明申请
    Substituted heterocyclic compounds and methods of use 审中-公开
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050107374A1

    公开(公告)日：2005-05-19

    申请号：US10969826

    申请日：2004-10-20

    申请人： Daniel Elbaum ,  Matthew Martin ,  Joseph Nunes

    发明人： Daniel Elbaum ,  Matthew Martin ,  Joseph Nunes

    IPC分类号： A61K31/505 ,  C07D403/04 ,  C07D473/12 ,  A61K31/52 ,  A61K31/5377 ,  A61K31/541

    CPC分类号： C07D403/04

    摘要： The present invention relates to hydroxybenzimidazole pyrimidines or pyridines or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, including ulcerative colitis, Crohn's disease, lupus, contact hypersensitivity, delayed-type hypersensitivity, and gluten-sensitive enteropathy, type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, glomerulonephritis, serum sickness, uticaria, allergic diseases, asthma, hayfever, allergic rhinitis, scleracielma, mycosis fungoides, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, atopic dermatitis, colon carcinoma or thymoma in a mammal comprising administering a therapeutically-effective amount a compound as described above.

    摘要翻译： 本发明涉及羟基苯并咪唑嘧啶或吡啶或其药学上可接受的盐。 还包括治疗炎症，抑制T细胞活化和增殖，关节炎，类风湿性关节炎，银屑病关节炎，骨关节炎，器官移植，急性移植或异种移植或同种移植物排斥，移植耐受性诱导，缺血或再灌注损伤，心肌梗死的方法 ，中风，多发性硬化，炎症性肠病，包括溃疡性结肠炎，克罗恩病，狼疮，接触性超敏反应，迟发型超敏反应和麸质敏感性肠病，1型糖尿病，牛皮癣，接触性皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进 ，艾迪生病，自身免疫性多腺病，自身免疫性脱发，恶性贫血，白癜风，自身免疫性低位症，吉兰巴利综合征，肾小球性肾炎，血清病，荨麻疹，过敏性疾病，哮喘，高粱，过敏性鼻炎，巩膜瘤，蕈样真菌病，皮肌炎，斑秃 ，慢性交感 包括给予治疗有效量的如上所述的化合物，包括给予治疗有效量的上述化合物，其中，所述治疗有效量的治疗有效量的药物组合物包括给予治疗有效量的上述化合物。

    Furanopyridine derivatives and methods of use
    4.
    发明申请
    Furanopyridine derivatives and methods of use 有权
    呋喃并吡啶衍生物和使用方法

    公开(公告)号：US20060046977A1

    公开(公告)日：2006-03-02

    申请号：US11184237

    申请日：2005-07-18

    申请人： Joseph Nunes ,  Matthew Martin ,  Ryan White ,  David McGowan ,  Jean Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  Xian Jiao

    发明人： Joseph Nunes ,  Matthew Martin ,  Ryan White ,  David McGowan ,  Jean Bemis ,  Frank Kayser ,  Jiasheng Fu ,  Jinqian Liu ,  Xian Jiao

    IPC分类号： A61K31/5377 ,  A61K31/496 ,  A61K31/4741 ,  C07F7/02 ,  C07D491/02 ,  A61K31/695

    CPC分类号： C07D491/04 ,  C07D491/14

    摘要： The present invention relates to furanopyridine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of modulating Lck and ACK-1 enzymes and of treating various related diseases and conditions, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, comprising administering to the mammal a therapeutically effective amount a compound of Formula I, as described above, and methods of manufacturing medicaments comprising the compound of Formula I.

    摘要翻译： 本发明涉及具有通式I的呋喃并吡啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，调节Lck和ACK-1酶的方法以及治疗各种相关疾病和病症，包括炎症，T细胞活化抑制，增殖，关节炎，器官移植，缺血或再灌注 损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球肾炎，过敏性疾病，哮喘 ，干草组织，湿疹，癌症，结肠癌，胸腺瘤，仅举几个例子，在哺乳动物中，包括向哺乳动物施用治疗有效量的如上所述的式I化合物和制备包含以下化合物的药物的方法： 一级方程式

    Method for stabilizing the gain of a pet detection system
    10.
    发明授权
    Method for stabilizing the gain of a pet detection system 有权
    稳定宠物检测系统增益的方法

    公开(公告)号：US07772559B2

    公开(公告)日：2010-08-10

    申请号：US12232451

    申请日：2008-09-17

    申请人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew Martin ,  Matthias Schmand

    发明人： Ziad Burbar ,  James Corbeil ,  Gregory Hayzen ,  Sridhar Kuppuswamy ,  Ralf Ladebeck ,  Matthew Martin ,  Matthias Schmand

    IPC分类号： G01T1/164

    CPC分类号： G01T1/1603 ,  A61B6/037 ,  G01T7/005

    摘要： A method for stabilizing the gain of a PET detection system with a cooling unit includes: determining the temperature of at least one component of the PET detection system, comparing the actual gain with a reference value, and actuating the cooling unit to influence the temperature such that the gain tends to the reference value. In at least one embodiment, the reference value is determined by determining the temperature of the at least one component during a test measurement, determining the gain during the test measurement, determining a functional dependence of the gain on the temperature, and selecting the reference value based on the gain to be stabilized. Advantageously, in at least one embodiment the gain can be kept constant using the described method in a simple manner, with the influence of the temperature of the components being taken into account.

    摘要翻译： 用于利用冷却单元稳定PET检测系统的增益的方法包括：确定PET检测系统的至少一个部件的温度，将实际增益与参考值进行比较，以及致动冷却单元以影响温度 增益趋于参考值。 在至少一个实施例中，参考值通过在测试测量期间确定至少一个组件的温度，确定测试测量期间的增益，确定增益对温度的功能依赖性以及选择参考值来确定 基于要稳定的收益。 有利地，在至少一个实施例中，利用所述方法以简单的方式，可以将增益保持恒定，同时考虑组件的温度的影响。