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12 条记录 (耗时 0.021 秒)

    Thienopyridine derivatives useful in treating gastric ulcers
    1.
    发明授权
    Thienopyridine derivatives useful in treating gastric ulcers 失效
    可用于治疗胃溃疡的噻吩并吡啶衍生物

    公开(公告)号：US4839365A

    公开(公告)日：1989-06-13

    申请号：US191057

    申请日：1988-05-06

    申请人： Kentaro Hirai ,  Yukio Mizushima ,  Masami Doteuchi

    发明人： Kentaro Hirai ,  Yukio Mizushima ,  Masami Doteuchi

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, or trifluoromethyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkoxycarbonyl, C.sub.6 -C.sub.12 aryloxycarbonyl, C.sub.1 -C.sub.5 alkanoyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxycarbonyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 acylamino-C.sub.1 -C.sub.5 alkyl, 2-hydroxy-1-C.sub.2 -C.sub.5 alkenyl, phthalimido-C.sub.1 -C.sub.5 alkyl, halogeno-C.sub.1 -C.sub.5 alkoxycarbonyl-C.sub.1 -C.sub.5 alkyl, hydroxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkylthio-C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkylsulfinyl-C.sub.1 -C.sub.5 alkyl; ##STR2## m is an integer of 0 or 1; R.sup.3 and R.sup.4 each is hydrogen, halogen, cyano, C.sub.1 -C.sub.5 alkyl, amino, C.sub.1 -C.sub.5 alkoxy, C.sub.6 -C.sub.12 aryl-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, fluoro-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

    9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives
    2.
    发明授权
    9-(Substituted thio)-4H-pyrido[1,2,-A]pyrimidin-4-one derivatives 失效
    9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物

    公开(公告)号：US4840953A

    公开(公告)日：1989-06-20

    申请号：US206665

    申请日：1988-06-15

    申请人： Shigeru Matsutani ,  Yukio Mizushima ,  Masami Doteuchi ,  Yasunobu Ishihara

    发明人： Shigeru Matsutani ,  Yukio Mizushima ,  Masami Doteuchi ,  Yasunobu Ishihara

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula: ##STR1## wherein n is 0 or 1, R is --COR.sup.1, --CONR.sup.4 R.sup.5 or --CH.sub.2 R.sup.6, R.sup.1 is C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl, allythio, styryl, phenoxymethyl, thienylmethyl, C.sub.6 -C.sub.10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R.sup.2 and R.sup.3 each is hydrogen, C.sub.1 -C.sub.5 alkyl, carboxy, C.sub.2 -C.sub.5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R.sup.4 and R.sup.5 each is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.3 -C.sub.7 cycloalkyl or phenyl optionally substituted, and R.sup.8 is pyridyl or phenyl optionally substituted) being useful as antiulcer agents are provided through several routes.

    摘要翻译： 9-（取代的硫代）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物其中n为0或1，R为-COR 1，-CONR 4 R 5或-CH 2 R 6 R1是C1-C5烷基，C3-C7环烷基，烯硫基，苯乙烯基，苯氧基甲基，噻吩基甲基，任选取代的C 6 -C 10芳基，任选取代的苄基，或任选被取代的5或6元杂环基，R 2和R 3各自是氢， C 1 -C 5烷基，羧基，C 2 -C 5烷氧基羰基或任选取代的苄氧基羰基，R 4和R 5各自为氢，C 1 -C 5烷基，C 3 -C 7环烷基或任选取代的苯基，R 8为任选取代的吡啶基或苯基）可用作抗溃疡剂 代理商通过几条路线提供。

    Thioethylamide derivatives
    4.
    发明授权
    Thioethylamide derivatives 失效
    硫代乙酰胺衍生物

    公开(公告)号：US4318858A

    公开(公告)日：1982-03-09

    申请号：US212222

    申请日：1980-12-02

    申请人： Kentaro Hirai ,  Shigeru Matsutani ,  Teruyuki Ishiba ,  Itsuo Makino ,  Masami Doteuchi ,  Koichi Otani

    发明人： Kentaro Hirai ,  Shigeru Matsutani ,  Teruyuki Ishiba ,  Itsuo Makino ,  Masami Doteuchi ,  Koichi Otani

    IPC分类号： C07D333/16 ,  A61K31/34 ,  A61K31/341 ,  A61P43/00 ,  C07D307/52 ,  C07D307/68 ,  C07D333/20 ,  C07D333/38 ,  C07D405/12 ,  C07D409/12 ,  C07D207/04 ,  C07D333/18

    CPC分类号： C07D307/68 ,  C07D307/52 ,  C07D333/20 ,  C07D333/38 ,  Y10S514/927

    摘要： A compound of the formula: ##STR1## [wherein R is dimethylamino or 1-pyrrolidinyl;R.sup.1 and R.sup.2 each is hydrogen or C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, C.sub.1 -C.sub.3 alkyl (optionally substituted by one member selected from the group consisting of cyano, C.sub.1 -C.sub.3 alkoxy, phenyl, and 5- or 6-membered heterocyclic group), C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.5 alkenyl (optionally substituted by one member selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, phenyl, and phenoxy), C.sub.6 -C.sub.10 aryl (optionally substituted by one or two members selected from the group consisting of hydroxy, halogen, nitro, sulfamoyl, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkanoyl, C.sub.2 -C.sub.4 alkoxycarbonyl, C.sub.2 -C.sub.4 dialkylamino, and C.sub.1 -C.sub.3 alkanesulfonyl), or 5- or 6-membered heterocyclic group (optionally substituted by one member selected from the group consisting of oxo, halogen, C.sub.1 -C.sub.3 alkyl, and C.sub.1 -C.sub.3 alkoxy);and X is oxygen or sulfur]and its pharmaceutically acceptable acid addition salts is useful as histamine H.sub.2 blockers.

    摘要翻译： 下式的化合物：其中R是二甲基氨基或1-吡咯烷基; R1和R2各自为氢或C1-C3烷基; R 3是氢，C 1 -C 3烷基（任选地被选自氰基，C 1 -C 3烷氧基，苯基和5-或6-元杂环基中的一个取代），C 3 -C 6环烷基，C 2 -C 5烯基（ 任选地被选自C 1 -C 3烷氧基，苯基和苯氧基的一个取代基取代），C 6 -C 10芳基（任选被一个或两个选自羟基，卤素，硝基，氨磺酰基，C1- C 3烷基，C 1 -C 3烷氧基，C 1 -C 3烷酰基，C 2 -C 4烷氧基羰基，C 2 -C 4二烷基氨基和C 1 -C 3烷磺酰基）或5或6元杂环基（任选被一个选自 的氧代，卤素，C 1 -C 3烷基和C 1 -C 3烷氧基）; 并且X是氧或硫]，其药学上可接受的酸加成盐可用作组胺H2阻断剂。