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31 条记录 (耗时 0.017 秒)

    Thienopyridine derivatives useful in treating gastric ulcers
    1.
    发明授权
    Thienopyridine derivatives useful in treating gastric ulcers 失效
    可用于治疗胃溃疡的噻吩并吡啶衍生物

    公开(公告)号：US4839365A

    公开(公告)日：1989-06-13

    申请号：US191057

    申请日：1988-05-06

    申请人： Kentaro Hirai ,  Yukio Mizushima ,  Masami Doteuchi

    发明人： Kentaro Hirai ,  Yukio Mizushima ,  Masami Doteuchi

    IPC分类号： C07D495/04

    CPC分类号： C07D495/04

    摘要： A compound of the formula: ##STR1## (wherein R.sup.1 is hydrogen, C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, or trifluoromethyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.5 alkoxycarbonyl, C.sub.6 -C.sub.12 aryloxycarbonyl, C.sub.1 -C.sub.5 alkanoyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxycarbonyloxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 acylamino-C.sub.1 -C.sub.5 alkyl, 2-hydroxy-1-C.sub.2 -C.sub.5 alkenyl, phthalimido-C.sub.1 -C.sub.5 alkyl, halogeno-C.sub.1 -C.sub.5 alkoxycarbonyl-C.sub.1 -C.sub.5 alkyl, hydroxy-C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkylthio-C.sub.1 -C.sub.5 alkyl, or C.sub.1 -C.sub.5 alkylsulfinyl-C.sub.1 -C.sub.5 alkyl; ##STR2## m is an integer of 0 or 1; R.sup.3 and R.sup.4 each is hydrogen, halogen, cyano, C.sub.1 -C.sub.5 alkyl, amino, C.sub.1 -C.sub.5 alkoxy, C.sub.6 -C.sub.12 aryl-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkoxycarbonyl, fluoro-C.sub.1 -C.sub.5 alkoxy, C.sub.1 -C.sub.5 alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

    Thioethylamide derivatives
    4.
    发明授权
    Thioethylamide derivatives 失效
    硫代乙酰胺衍生物

    公开(公告)号：US4318858A

    公开(公告)日：1982-03-09

    申请号：US212222

    申请日：1980-12-02

    申请人： Kentaro Hirai ,  Shigeru Matsutani ,  Teruyuki Ishiba ,  Itsuo Makino ,  Masami Doteuchi ,  Koichi Otani

    发明人： Kentaro Hirai ,  Shigeru Matsutani ,  Teruyuki Ishiba ,  Itsuo Makino ,  Masami Doteuchi ,  Koichi Otani

    IPC分类号： C07D333/16 ,  A61K31/34 ,  A61K31/341 ,  A61P43/00 ,  C07D307/52 ,  C07D307/68 ,  C07D333/20 ,  C07D333/38 ,  C07D405/12 ,  C07D409/12 ,  C07D207/04 ,  C07D333/18

    CPC分类号： C07D307/68 ,  C07D307/52 ,  C07D333/20 ,  C07D333/38 ,  Y10S514/927

    摘要： A compound of the formula: ##STR1## [wherein R is dimethylamino or 1-pyrrolidinyl;R.sup.1 and R.sup.2 each is hydrogen or C.sub.1 -C.sub.3 alkyl;R.sup.3 is hydrogen, C.sub.1 -C.sub.3 alkyl (optionally substituted by one member selected from the group consisting of cyano, C.sub.1 -C.sub.3 alkoxy, phenyl, and 5- or 6-membered heterocyclic group), C.sub.3 -C.sub.6 cycloalkyl, C.sub.2 -C.sub.5 alkenyl (optionally substituted by one member selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, phenyl, and phenoxy), C.sub.6 -C.sub.10 aryl (optionally substituted by one or two members selected from the group consisting of hydroxy, halogen, nitro, sulfamoyl, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 alkanoyl, C.sub.2 -C.sub.4 alkoxycarbonyl, C.sub.2 -C.sub.4 dialkylamino, and C.sub.1 -C.sub.3 alkanesulfonyl), or 5- or 6-membered heterocyclic group (optionally substituted by one member selected from the group consisting of oxo, halogen, C.sub.1 -C.sub.3 alkyl, and C.sub.1 -C.sub.3 alkoxy);and X is oxygen or sulfur]and its pharmaceutically acceptable acid addition salts is useful as histamine H.sub.2 blockers.

    摘要翻译： 下式的化合物：其中R是二甲基氨基或1-吡咯烷基; R1和R2各自为氢或C1-C3烷基; R 3是氢，C 1 -C 3烷基（任选地被选自氰基，C 1 -C 3烷氧基，苯基和5-或6-元杂环基中的一个取代），C 3 -C 6环烷基，C 2 -C 5烯基（ 任选地被选自C 1 -C 3烷氧基，苯基和苯氧基的一个取代基取代），C 6 -C 10芳基（任选被一个或两个选自羟基，卤素，硝基，氨磺酰基，C1- C 3烷基，C 1 -C 3烷氧基，C 1 -C 3烷酰基，C 2 -C 4烷氧基羰基，C 2 -C 4二烷基氨基和C 1 -C 3烷磺酰基）或5或6元杂环基（任选被一个选自 的氧代，卤素，C 1 -C 3烷基和C 1 -C 3烷氧基）; 并且X是氧或硫]，其药学上可接受的酸加成盐可用作组胺H2阻断剂。

    1-Substituted thiomethyltriazolobenzodiazepines
    10.
    发明授权
    1-Substituted thiomethyltriazolobenzodiazepines 失效
    1-取代的硫代甲基三唑并苯并二氮杂卓

    公开(公告)号：US4231930A

    公开(公告)日：1980-11-04

    申请号：US16615

    申请日：1979-03-01

    申请人： Kentaro Hirai ,  Toshio Fujishita ,  Teruyuki Ishiba

    发明人： Kentaro Hirai ,  Toshio Fujishita ,  Teruyuki Ishiba

    IPC分类号： A61K31/55 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  C07D249/08 ,  C07D487/04 ,  C07D519/00

    CPC分类号： C07D249/08 ,  C07D487/04 ,  Y02P20/55

    摘要： A compound of the formula: ##STR1## wherein R is hydrogen, 2-5C alkoxycarbonyl, 1-7C acyl, 1-4C alkylthio, 7-10C phenylalkylthio, phenylthio, halo-phenylthio, disubstituted aminothio, ##STR2## R.sup.1 is hydrogen or halogen; R.sup.2 is halogen or nitro;and its pharmaceutically acceptable acid addition salts. The compounds and salts thereof are useful as psychotropic agents and as anxiolytics, anticonvulsants and hypnotics.

    摘要翻译： 下式的化合物：其中R是氢，2-5C烷氧基羰基，1-7C酰基，1-4C烷硫基，7-10C苯基烷硫基，苯硫基，卤代苯硫基，二取代氨基硫代，＆lt; IMAGE＆gt; + TR＆lt; IMAGE > R1是氢或卤素; R2是卤素或硝基; 及其药学上可接受的酸加成盐。 其化合物和盐可用作精神药物和抗焦虑剂，抗惊厥药和催眠药。