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    Systems and method for biological analysis
    1.
    发明授权
    Systems and method for biological analysis 有权

    公开(公告)号：US10252272B2

    公开(公告)日：2019-04-09

    申请号：US14893356

    申请日：2014-05-27

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Michael Pallas ,  Evan Foster ,  Jorge Fonseca ,  James Nurse ,  Theodore Straub

    IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12Q1/686 ,  G01N21/64

    Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The support is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.

    Systems and methods for transfer of liquid samples
    2.
    发明授权
    Systems and methods for transfer of liquid samples 有权

    公开(公告)号：US10821444B2

    公开(公告)日：2020-11-03

    申请号：US15457633

    申请日：2017-03-13

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Ronald Danehy ,  Jorge Fonseca ,  Jayanthi Prasad

    IPC: G01N35/10 ,  B01L3/00 ,  B01L3/02

    Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.

    Systems and methods for biological analysis
    7.
    发明授权
    Systems and methods for biological analysis 有权

    公开(公告)号：US10994275B2

    公开(公告)日：2021-05-04

    申请号：US16291757

    申请日：2019-03-04

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Michael Pallas ,  Evan Foster ,  Jorge Fonseca ,  James Nurse ,  Theodore Straub

    IPC: B01L3/00 ,  B01L7/00 ,  B01L9/00 ,  C12Q1/686 ,  G01N21/64

    Abstract: A system for processing a plurality of biological samples contains a support and a temperature controller. The suppose is configured to hold a case that includes an inner chamber and a substrate located within the inner chamber, the substrate containing a plurality of isolated reaction sites containing one or more biological samples. The temperature controller is configured to maintain or control a temperature of at least one of the support, the case, or the one or more biological samples during an assay or reaction on the one or more biological samples. The support is also configured to maintain at least one of the surfaces of substrate at a positive angle relative to a horizontal plane during the assay or reaction.

    Systems and Methods for Containing Biological Samples
    9.
    发明申请
    Systems and Methods for Containing Biological Samples 审中-公开
    包含生物样品的系统和方法

    公开(公告)号：US20150044686A1

    公开(公告)日：2015-02-12

    申请号：US14385765

    申请日：2013-03-15

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Michael Pallas ,  James C. Nurse ,  Kevin Maher ,  Jorge Fonseca ,  Eliodor Ghenciu ,  Evan Foster

    IPC: C12Q1/68 ,  B01L3/00 ,  G03F7/20

    CPC classification number: B01L3/50857 ,  B01L3/50 ,  B01L3/50851 ,  B01L7/52 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0893 ,  B01L2300/0896 ,  B01L2300/161 ,  C12Q1/6806 ,  C12Q1/686 ,  G03F7/2002

    Abstract: An article for holding a plurality of biological samples includes a substrate a substrate comprising a first surface and an opposing second surface and a plurality of reaction sites in the substrate. Each of the reaction sites extends from an opening in the first surface to an opening in the second surface. The reaction sites comprise a hexagonal shape and are configured to provide sufficient surface tension by capillary action to hold respective biological samples. The reaction sites have a density over at least a portion of the surfaces that is at least 170 holes per square millimeter. At least one of the surfaces may have a surface roughness characterized by an arithmetic average roughness (Ra) that is less than or equal to 5 nanometers.

    Abstract translation: 用于保持多个生物样品的制品包括基材，其包含基材中的第一表面和相对的第二表面和多个反应位点。 每个反应位点从第一表面中的开口延伸到第二表面中的开口。 反应位点包括六边形形状并且被配置为通过毛细作用提供足够的表面张力以保持各自的生物样品。 反应部位的表面密度至少在每平方毫米170个孔以上。 至少一个表面可以具有由小于或等于5纳米的算术平均粗糙度（Ra）表征的表面粗糙度。

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