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公开(公告)号：US12070731B2
公开(公告)日：2024-08-27
申请号：US17505075
申请日：2021-10-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
CPC classification number: B01J19/0046 , B01L3/50857 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01L3/0244 , B01L3/5025 , B01L2200/12 , B01L2200/16 , B01L2300/16
Abstract: A method of registering a location of a dispenser array in relation to a microfluidic array is provided. One of the dispenser array and the microfluidic array can be movable in relation to the frame, and the other can be fixed relative to the frame. Their relative positions can be identified by a set of coordinates. Identification of a fiducial marker can occur in a manner permitting the fiducial reference to appear in a first position of a field of view of a first camera when the dispenser array or the microfluidic array is in an alignment position. Quantities related to a vector displacement from the alignment position to a fixed position on the microfluidic array or the dispenser array can be identified. Quantities determined can be used to guide positioning of the dispenser array relative to the microfluidic array.
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公开(公告)号：US20150011436A1
公开(公告)日：2015-01-08
申请号：US14300100
申请日：2014-06-09
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Colin J. H. Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya S. Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/0059 , B01J2219/00596 , B01J2219/00659 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L2200/12 , B01L2200/16 , B01L2300/16
Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
Abstract translation: 一种用于进行多个纳米体积规定的反应的差异涂覆的装置，所述装置包括具有至少一个被修饰至指定理化特性的外表面的压板，多个纳米体积通道，每个纳米体积通道具有至少一个 与所述至少一个外表面连通的内表面，其被选择性地涂覆有物理吸附到至少一个内表面上的任选可溶解的涂覆剂，其中所述任选可溶解的涂覆剂包含涂层剂和用于多个特定反应的第一组分。 还提供了用于制备和使用这种装置的方法，以及相对于微流体阵列登记分配器阵列的位置的方法。 分配器阵列和微流体阵列中的第一个可相对于框架移动，并且分配器阵列和微流体阵列中的第一个中的另一个相对于框架是固定的。 确定与分配器阵列和微流体阵列之一上的对准位置到固定位置的矢量位移有关的量。 这样确定的量用于引导分配器阵列相对于微流体阵列的定位。
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3.发明申请公开(公告)号：US20180361345A1
公开(公告)日：2018-12-20
申请号：US15978523
申请日：2018-05-14
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
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公开(公告)号：US10065189B2
公开(公告)日：2018-09-04
申请号：US15049710
申请日：2016-02-22
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tanya S. Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin John Herbert Brenan
Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
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公开(公告)号：US09968903B2
公开(公告)日：2018-05-15
申请号：US15131101
申请日：2016-04-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Robert Hess , John Linton , Tanya S. Kanigan , Colin Brenan , Can Ozbal
IPC: B01J19/00 , B01L3/02 , B01L3/00 , C40B60/14 , G01N30/46 , G01N30/60 , B01L99/00 , C12M1/32 , G01N30/82 , G01N30/84
CPC classification number: B01J19/0046 , B01J2219/00317 , B01J2219/00319 , B01J2219/00351 , B01J2219/0036 , B01J2219/00369 , B01J2219/00387 , B01J2219/00389 , B01J2219/00423 , B01J2219/0043 , B01J2219/00479 , B01J2219/00495 , B01J2219/005 , B01J2219/00511 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00673 , B01L3/0244 , B01L3/0262 , B01L3/0268 , B01L3/5025 , B01L3/50255 , B01L3/5085 , B01L3/50857 , B01L99/00 , B01L2200/0657 , B01L2300/0845 , C12M23/12 , C40B60/14 , G01N30/466 , G01N30/6091 , G01N30/6095 , G01N30/82 , G01N2030/8417
Abstract: The invention features methods of making devices, or “platens”, having a high-density array of through-holes, as well as methods of cleaning and refurbishing the surfaces of the platens. The invention further features methods of making high-density arrays of chemical, biochemical, and biological compounds, having many advantages over conventional, lower-density arrays. The invention includes methods by which many physical, chemical or biological transformations can be implemented in serial or in parallel within each addressable through-hole of the devices. Additionally, the invention includes methods of analyzing the contents of the array, including assaying of physical properties of the samples.
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Patent Agency Ranking
公开(公告)号：US20140031262A1
公开(公告)日：2014-01-30
申请号：US14042458
申请日：2013-09-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tanya S. Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin Brennan
IPC: B01L3/00
CPC classification number: B01L3/5085 , B01L3/0241 , B01L3/0244 , B01L3/5025 , B01L3/50857 , B01L3/563 , B01L2200/021 , B01L2200/027 , B01L2200/0605 , B01L2200/0636 , B01L2200/0642 , B01L2200/16 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/12 , B01L2300/161 , B33Y70/00 , B33Y80/00 , Y10T137/0318 , Y10T137/1624 , Y10T137/206 , Y10T436/2525
Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
Abstract translation: 提供了用于将微流体样品存储在纳升级样品芯片中的界面。 流体通道结构从样品阱阵列向选定的样品阱子集提供流体通路区域。 流体引入机构将样品流体引入流体存取区域，使得所选择的子集中的样品孔填充有样品流体，而未选择的样品池填充有样品流体。
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公开(公告)号：US11154834B2
公开(公告)日：2021-10-26
申请号：US16284953
申请日：2019-02-25
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Colin Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nanovolume channel having at least one interior surface in communication with the at least one exterior surface. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
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公开(公告)号：US10974247B2
公开(公告)日：2021-04-13
申请号：US16119327
申请日：2018-08-31
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Tanya S. Kanigan , Steve Smith , John Linton , Robert Hess , Karl Yoder , Colin J. H. Brenan
Abstract: An interface is provided for storing microfluidic samples in a nanoliter sample chip. A fluid access structure provides a fluid access region to a selected subset of sample wells from an array of sample wells. A fluid introduction mechanism introduces a sample fluid to the fluid access region so that the sample wells in the selected subset are populated with the sample fluid without the unselected sample wells being populated with the sample fluid.
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公开(公告)号：US10213761B2
公开(公告)日：2019-02-26
申请号：US14300100
申请日：2014-06-09
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Colin J. H. Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya S. Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
Abstract: A differentially coated device for conducting a plurality of nano-volume specified reactions, the device comprising a platen having at least one exterior surface modified to a specified physicochemical property, a plurality of nano-volume channels, each nano-volume channel having at least one interior surface in communication with the at least one exterior surface that is selectively coated with an optionally dissolvable coating agent physisorbed to at least one interior surface, wherein the optionally dissolvable coating agent comprises a coating agent and a first component for the plurality of specified reactions. Methods for preparing and using such devices are also provided, as well as a method of registering a location of a dispenser array in relation to a microfluidic array. A first one of the dispenser array and the microfluidic array is movable in relation to the frame, and the other of the first one of the dispenser array and the microfluidic array is fixed relative to the frame. Quantities related to a vector displacement from the alignment position to a fixed position on the one of the dispenser array and the microfluidic array is determined. The quantities thus determined are used to guide positioning of the dispenser array relative to the microfluidic array.
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公开(公告)号：US20240367137A1
公开(公告)日：2024-11-07
申请号：US18776608
申请日：2024-07-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Colin J.H. Brenan , Jamie Cho , Javier Garcia , Robert Hess , Tanya S. Kanigan , Arrin Katz , Namyong Kim , John Linton , Shailesh Srivastava , Karl Yoder
Abstract: A method of registering a location of a dispenser array in relation to a microfluidic array is provided. One of the dispenser array and the microfluidic array can be movable in relation to the frame, and the other can be fixed relative to the frame. Their relative positions can be identified by a set of coordinates. Identification of a fiducial marker can occur in a manner permitting the fiducial reference to appear in a first position of a field of view of a first camera when the dispenser array or the microfluidic array is in an alignment position. Quantities related to a vector displacement from the alignment position to a fixed position on the microfluidic array or the dispenser array can be identified. Quantities determined can be used to guide positioning of the dispenser array relative to the microfluidic array.
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