公开(公告)号：US20240293822A1

公开(公告)日：2024-09-05

申请号：US18436879

申请日：2024-02-08

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Stephen HIGGINS ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kenneth PAGE ,  Kristian ROTH ,  George SIGAL

IPC: B01L7/00 ,  B01L3/00 ,  C12Q1/686

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0883 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  C12Q1/686

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20220097072A1

公开(公告)日：2022-03-31

申请号：US17492207

申请日：2021-10-01

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Kenneth PAGE ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kristian ROTH

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US20210291168A1

公开(公告)日：2021-09-23

申请号：US17215962

申请日：2021-03-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Sudeep KUMAR ,  Pankaj OBEROI ,  George SIGAL ,  Michael TSIONSKY

IPC: B01L3/00 ,  C12Q1/6804 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/6816 ,  C12Q1/6876

Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20240382969A1

公开(公告)日：2024-11-21

申请号：US18671149

申请日：2024-05-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. GLEZER ,  Bandele JEFFREY-COKER ,  Kenneth PAGE ,  Sandor KOVACS ,  Sudeep KUMAR ,  Kristian ROTH

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are scaled.

公开(公告)号：US20240347167A1

公开(公告)日：2024-10-17

申请号：US18595584

申请日：2024-03-05

Applicant: MESO SCALE TECHNOLOGIES, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. BLAKELY ,  Eli N. GLEZER ,  John H. KENTEN ,  Sudeep KUMAR ,  Anu MATHEW ,  Natalia I. OSSETROVA ,  George SIGAL

IPC: G16H20/40 ,  G01N27/327 ,  G01N33/68 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02

CPC classification number: G16H20/40 ,  G01N27/3273 ,  G01N33/6893 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20220341843A1

公开(公告)日：2022-10-27

申请号：US17733036

申请日：2022-04-29

Applicant: Meso Scale Technologies, LLC.

Inventor： Nicholas ANDERSON ,  Jeffery DEBAD ,  Eli N. GLEZER ,  Sudeep KUMAR ,  Noel LAWRENCE ,  Kenneth PAGE ,  George SIGAL ,  Sharon WEST

IPC: G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, thy reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20240375109A1

公开(公告)日：2024-11-14

申请号：US18597358

申请日：2024-03-06

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Eli N. GLEZER ,  Sudeep KUMAR ,  Pankaj OBEROI ,  George SIGAL ,  Michael TSIONSKY

IPC: B01L3/00 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6876 ,  G01N33/543 ,  G01N33/68

Abstract: The invention relates to methods for conducting solid-phase binding assays. Onc example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.

公开(公告)号：US20230175043A1

公开(公告)日：2023-06-08

申请号：US17607731

申请日：2020-04-30

Applicant: Meso Scale Technologies, LLC.

Inventor： John KENTEN ,  Sudeep KUMAR ,  Galina NIKOLENKO ,  Laukik SARDESAI ,  Alexander K. TUCKER-SCHWARTZ ,  George SIGAL ,  Seth Beebe HARKINS ,  Robert UMEK ,  Timothy J. BREAK ,  Laure MOLLER

IPC: C12Q1/6825

CPC classification number: C12Q1/6825 ,  C12Q1/6837 ,  C12Q2600/16

Abstract: Oligonucleotides, methods and kits are provided for detecting, identifying or quantifying one or more target analytes in a sample as well as methods for immobilizing oligonucleotides onto a support surface.