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公开(公告)号：US5434245A
公开(公告)日：1995-07-18
申请号：US993980
申请日：1992-12-16
申请人： Nobuto Koyama , Fusao Kimizuka , Ikunoshin Kato
发明人： Nobuto Koyama , Fusao Kimizuka , Ikunoshin Kato
IPC分类号： C12P21/02 , A61K38/00 , A61P3/02 , A61P37/00 , A61P43/00 , C07K1/22 , C07K14/00 , C07K14/51 , C07K14/52 , C07K14/78 , C07K19/00 , C12N15/09 , C12N15/12 , C12P21/06 , C12R1/19 , C07K14/47 , C07K14/70
CPC分类号： C07K14/78
摘要： There is provided a polypeptide having the following formula (I'), and which polypeptide is referred to as Glu-OC and a process for the preparation thereof. ##STR1##
摘要翻译： 提供具有下式（I'）的多肽，该多肽称为Glu-OC及其制备方法。
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公开(公告)号：US5045631A
公开(公告)日：1991-09-03
申请号：US310170
申请日：1989-02-13
IPC分类号： C12N15/09 , A61K38/00 , A61P43/00 , C07K1/22 , C07K14/00 , C07K14/78 , C07K16/00 , C12N1/20 , C12N1/21 , C12P21/02 , C12R1/19
摘要： A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
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公开(公告)号：US5496717A
公开(公告)日：1996-03-05
申请号：US348961
申请日：1994-11-28
CPC分类号： C12N9/22 , Y10S435/814
摘要： A new restriction endonuclease capable of recognizing the nucleotide sequence of the following formula 1 in double stranded DNA. ##STR1## and specifically cleaving it is disclosed. The endonuclease may be made cultivating a strain of the genus Streptomyces (FERM BP-4836) capable of producing it.
摘要翻译： 能够识别双链DNA中下式1的核苷酸序列的新的限制性内切核酸酶。 公开了[化学式1]并具体地分解它。 可以使内切核酸酶培养能够产生它的链霉菌属（FERM BP-4836）的菌株。
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4.发明授权Functional polypeptide containing a cell binding domain and a heparin binding domain of fibronectin 失效包含细胞结合域的功能多肽和纤连蛋白的肝素结合域
公开(公告)号：US5198423A
公开(公告)日：1993-03-30
申请号：US526733
申请日：1990-05-22
申请人： Yuki Taguchi , Yoh'ichi Ohdate , Yasutoshi Kawase , Shouichi Goto , Fusao Kimizuka , Ikunoshin Kato , Ikuo Saiki , Ichiro Azuma
发明人： Yuki Taguchi , Yoh'ichi Ohdate , Yasutoshi Kawase , Shouichi Goto , Fusao Kimizuka , Ikunoshin Kato , Ikuo Saiki , Ichiro Azuma
摘要： This invention relates to a functional polypeptide containing the binding domain of human fibronectin and the heparin-binding domain of human fibronectin.
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公开(公告)号：US5102988A
公开(公告)日：1992-04-07
申请号：US362983
申请日：1989-06-08
IPC分类号： C12P21/02 , A61K8/00 , A61K8/64 , A61K8/72 , A61K8/99 , A61K38/00 , A61K38/16 , A61P17/00 , A61P27/02 , A61P35/00 , A61P43/00 , A61Q11/00 , A61Q19/00 , C07K1/22 , C07K14/78 , C12N1/21 , C12N15/00 , C12N15/09 , C12R1/19 , C12R1/91
摘要： A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
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公开(公告)号：US5475100A
公开(公告)日：1995-12-12
申请号：US109106
申请日：1993-08-19
申请人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
发明人： Kimikazu Hashino , Fusao Kimizuka , Ikunoshin Kato , Yoshikazu Kurosawa , Koiti Titani , Kiyotoshi Sekiguchi
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , C07K14/00 , C07K16/00 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/02 , C12P21/08 , C12R1/91 , C07H21/00
CPC分类号： C07K16/00 , A61K38/00 , C07K2317/77
摘要： This invention provides an antibody having antigen binding activity and which has a heavy chain constant region into which has been introduced an RGDS amino acid sequence giving the antibody affinity for cells, including macrophages. The antibody exhibits artificial cell adhesive activity which is the newly expressed activity that results from insertion of the RGDS amino acid sequence. This antibody having artificial cell adhesive activity can accelerate the phagocytosis of macrophages, and can activate other effector cells. Therefore, this antibody contributes to the self-defense mechanism.
摘要翻译： 本发明提供具有抗原结合活性的抗体，其具有重链恒定区，其中已引入RGDS氨基酸序列，其给予对包括巨噬细胞的细胞的抗体亲和力。 抗体表现出人工细胞粘附活性，其是由RGDS氨基酸序列的插入引起的新表达的活性。 具有人造细胞粘附活性的该抗体可以加速巨噬细胞的吞噬作用，并可以激活其他效应细胞。 因此，该抗体有助于自卫机制。
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公开(公告)号：US5189144A
公开(公告)日：1993-02-23
申请号：US852343
申请日：1992-03-17
申请人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
发明人： Kiyozo Asada , Takashi Uemori , Masahiro Endo , Fusao Kimizuka , Ikunoshin Kato
CPC分类号： C07K7/08 , C07K14/8139
摘要： Polypeptides are provided which have a calpain inhibitory activity. The polypeptides have an activity like that of natural human calpastatin but are significantly shorter in length than natural human calpastatin. The polypeptides are suited for synthetic manufacture.
摘要翻译： 提供具有钙蛋白酶抑制活性的多肽。 多肽具有类似于天然人钙蛋白酶抑制剂的活性，但其长度明显短于天然人钙蛋白酶抑制剂。 该多肽适用于合成制造。
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公开(公告)号：US5179016A
公开(公告)日：1993-01-12
申请号：US698780
申请日：1991-05-13
申请人： Hirokazu Kotani , Fusao Kimizuka , Ikunoshin Kato
发明人： Hirokazu Kotani , Fusao Kimizuka , Ikunoshin Kato
CPC分类号： C12N9/22 , Y10S435/886
摘要： The class II restriction endonuclease Sse 8387I is obtained from Streptomyces Sp 837 (FERM BP-3028). It recognizes the nucleotide sequence 5'-CCTGCA.dwnarw.GG-3' and cleaves at the position indicated by the arrow.
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公开(公告)号：US5302701A
公开(公告)日：1994-04-12
申请号：US959369
申请日：1992-10-13
申请人： Hidetaka Hashi , Fusao Kimizuka , Ikunoshin Kato , Mika Hatai , Yoshihito Yaoi
发明人： Hidetaka Hashi , Fusao Kimizuka , Ikunoshin Kato , Mika Hatai , Yoshihito Yaoi
IPC分类号： A61K38/00 , A61P17/00 , A61P43/00 , C07K14/50 , C07K14/52 , C07K14/78 , C07K19/00 , C12N15/09 , C12P21/02 , C12R1/19 , A61K35/14 , C07K13/00
CPC分类号： C07K14/50 , C07K14/78 , A61K38/00 , C07K2319/00 , Y10S530/83
摘要： This present invention is directed to an artificial functional polypeptide represented by the following structural formula [I]:X--(Y)m--Z [I]wherein X represents a polypeptide having cell-adhesive activity like that of human FN, Y represents a spacer, Z represents a polypeptide having fibroblast growth promoting activity like that of FGF, and m is 1 or 0. This polypeptide is particularly useful for pharmaceutical purposes.
摘要翻译： 本发明涉及由以下结构式（I）表示的人造功能多肽：X-（Y）mZ（I）其中X表示具有类似于人FN的细胞粘附活性的多肽，Y表示间隔基， Z表示具有如FGF的成纤维细胞生长促进活性的多肽，m为1或0.该多肽特别适用于制药目的。
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公开(公告)号：US5136023A
公开(公告)日：1992-08-04
申请号：US437556
申请日：1989-11-16
申请人： Kimikazu Hashino , Shouichi Goto , Yasutoshi Kawase , Yoh'ichi Ohdate , Yuki Taguchi , Tatsuru Kinoshita , Fusao Kimizuka , Ikunoshin Kato
发明人： Kimikazu Hashino , Shouichi Goto , Yasutoshi Kawase , Yoh'ichi Ohdate , Yuki Taguchi , Tatsuru Kinoshita , Fusao Kimizuka , Ikunoshin Kato
IPC分类号： C12N15/09 , A61K8/64 , A61K38/00 , A61K38/16 , A61P17/00 , A61P27/02 , A61P43/00 , A61Q11/00 , A61Q19/00 , C07K14/78 , C12N1/21 , C12N15/00 , C12P21/02 , C12R1/19
摘要： A polypeptide having the cell-spreading activity of human fibronectin. Methods of preparing the polypeptide are described.
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