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公开(公告)号：US20060099592A1
公开(公告)日：2006-05-11
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Gouliaev , Mikkel Lundorf , Jakob Felding , Eva Olsen , Anette Holtmann , Soeren Jakobsen , Christian Sams , Sanne Glad , Kim Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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公开(公告)号：US20060166197A1
公开(公告)日：2006-07-27
申请号：US10507842
申请日：2003-03-14
申请人： Alex Gouliaev , Justin Ho , Jakob Felding , Christian Sams , Henrik Pedersen , Kim Jensen , Anders Hansen , Mikkel Lundorf , Gitte Husemoen , Thomas Franch , Thomas Thisted
发明人： Alex Gouliaev , Justin Ho , Jakob Felding , Christian Sams , Henrik Pedersen , Kim Jensen , Anders Hansen , Mikkel Lundorf , Gitte Husemoen , Thomas Franch , Thomas Thisted
IPC分类号： C40B40/08 , C07H21/02 , C07F9/6512
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is disclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译： 具有转移遗传信息的双重能力的构建块，例如， 通过识别编码元件并将功能实体传送到接收者反应组。 构建块可以设计成具有可调节的可转移性，同时考虑到构件的部件。 构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。 复合物库可用于寻求药物活性化合物。
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公开(公告)号：US09109248B2
公开(公告)日：2015-08-18
申请号：US13455223
申请日：2012-04-25
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifuntional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactant(s) at the priming site is using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 反应物，并且提供标识起始位点处的反应物的各个标签是使用一种或多种酶。
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公开(公告)号：US20090264300A1
公开(公告)日：2009-10-22
申请号：US12095778
申请日：2006-12-01
申请人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
发明人： Thomas Franch , Mikkel Dybro Lundorf , Soren Nyboe Jacobsen , Eva Kampmann Olsen , Anne Lee Andersen , Anette Holtmann , Anders Holm Hansen , Anders Malling Sorensen , Anne Goldbech , Daen de Leon , Ditte Kievsmose Kaldor , Frank Abildgaard Slok , Gitte Nystrup Husemoen , Johannes Dolberg , Kim Birkebaek Jensen , Lene Pedersen , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Sore Neve , Thomas Thisted , Tine Titilola Akinleminu Kronborg , Christian Klarner Sams , Jakob Felding , Per-Ola Freskgard , Alex Haahr Gouliaev , Henrik Pedersen
CPC分类号： C12N15/1068 , C12N15/1089 , C40B40/08 , C40B50/04 , C40B50/06
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).
摘要翻译： 公开了一种获得包含与单链标识符寡核苷酸连接的分子的双功能复合物的方法，其中包含化学反应位点的新生双功能复合物和用于酶标记添加的引发位点是a）在化学反应位点与 一种或多种反应物，和b）在起始位点用一种或多种标记反应物的标签进行酶促反应。
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公开(公告)号：US08206901B2
公开(公告)日：2012-06-26
申请号：US10525817
申请日：2003-10-30
申请人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
发明人： Per-Ola Freskgard , Thomas Franch , Alex Haahr Gouliaev , Mikkel Dybro Lundorf , Jakob Felding , Eva Kampmann Olsen , Anette Holtmann , Soeren Nyboe Jakobsen , Christian Klarner Sams , Sanne Schroeder Glad , Kim Birkebaek Jensen , Henrik Pedersen
CPC分类号： C12N15/1065 , C12N15/1068 , C12Q1/6806 , C12Q2521/101 , C12Q2521/501 , C40B50/10 , C40B50/16
摘要： Disclosed is a method for obtaining a bifunctional complex comprising a display molecule part and a coding part, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is reacted at the chemical reaction site with one or more reactants, and provided with respective tag(s) identifying the reactants(s) at the priming site using one or more enzymes.
摘要翻译： 公开了一种获得包含显示分子部分和编码部分的双功能复合物的方法，其中包含化学反应位点的初生双功能复合物和用于酶标记添加的引发位点在化学反应位点与一个或多个 并且使用一种或多种酶提供标识启动位点处的反应物的各个标签。
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公开(公告)号：US20100016177A1
公开(公告)日：2010-01-21
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Slok , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Norregaard-Madsen , Michael Anders Godskesen , Sanne Schroder Glad , Thomas Thisted , Per-Ola Freskgard , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesising templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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7.发明申请公开(公告)号：US20050176948A1
公开(公告)日：2005-08-11
申请号：US10507936
申请日：2003-03-14
申请人： Alex Gouliaev , Henrik Pedersen , Thomas Thisted , Mikkel Lundorf , Christian Sams , Thomas Franch , Gitte Husemoen , Justin Ho
发明人： Alex Gouliaev , Henrik Pedersen , Thomas Thisted , Mikkel Lundorf , Christian Sams , Thomas Franch , Gitte Husemoen , Justin Ho
IPC分类号： C07B61/00 , C07D405/04 , C07F9/6558 , C07F9/6561 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/10 , C12P19/34
CPC分类号： C07D405/04 , C07B2200/11 , C07F9/65586 , C07F9/65616 , C07H21/00 , C07H21/02 , C07H23/00 , C12N15/1068 , C12P19/34 , C40B40/00
摘要： A building block having the dual capabilities of transferring the genetic information e.g. by recognising an encoding element and transferring a functional entity to a recipient reactive group is diclosed. The building block can be designed with an adjustable transferability taking into account the components of the building block. The building block may be used in the generation of a single complex or libraries of different complexes, wherein the complex comprises an encoded molecule linked to an encoding element. Libraries of complexes are useful in the quest for pharmaceutically active compounds.
摘要翻译： 具有转移遗传信息的双重能力的构建块，例如， 通过识别编码元素并将功能实体传送到接收者反应组被关闭。 构建块可以设计成具有可调节的可转移性，同时考虑到构件的部件。 构建单元可以用于生成单个复合体或不同复合物的文库，其中复合物包含与编码元件连接的编码分子。 复合物库可用于寻求药物活性化合物。
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公开(公告)号：US08932992B2
公开(公告)日：2015-01-13
申请号：US12330709
申请日：2008-12-09
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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公开(公告)号：US08808984B2
公开(公告)日：2014-08-19
申请号：US12179323
申请日：2008-07-24
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H21/00 , C07H21/04 , C12Q1/6816 , C40B40/06 , C40B40/14
摘要： The invention relates to a method for synthesizing templated molecules attached to the templated which directed the synthesis thereof. The method involves a template, a scaffold functional entity and a functional entity attached to a building block, which, in turn, is attached the template. The scaffold functional entity and the functional entity of the building block are both provided with complementary dimerization domains allowing the functional entities to come into close proximity when the complementary domains interact with to each other. The method may be used for generating libraries of templated molecules which may be selected for biological activity.
摘要翻译： 本发明涉及一种合成连接于模板的模板分子的方法，其指导其合成。 该方法涉及模板，脚手架功能实体和连接到构件块的功能实体，其又附接模板。 支架功能实体和构建单元的功能实体都具有互补的二聚化结构域，使得当互补结构域彼此相互作用时，功能实体能够接近。 该方法可以用于产生可以选择用于生物活性的模板分子的文库。
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公开(公告)号：US07727713B2
公开(公告)日：2010-06-01
申请号：US10175539
申请日：2002-06-20
申请人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
发明人： Henrik Pedersen , Alex Haahr Gouilaev , Thomas Franch , Christian Klarner Sams , Eva Kampmann Olsen , Frank Abilgaard Sløk , Gitte Nystrup Husemoen , Jakob Felding , Lene Hyldtoft , Mads Nørregaard-Madsen , Michael Anders Godskesen , Sanne Schrøder Glad , Thomas Thisted , Per-Ola Freskgård , Anette Holtmann
CPC分类号： C12N15/1068 , C07B2200/11 , C07D405/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C12N15/1058 , C12P19/34 , C40B40/00
摘要： The present invention relates to a method for synthesizing templated molecules. In one aspect of the invention, the templated molecules are linked to the template which templated the synthesis thereof. The intion allows the generation of libraries which can be screened for e.g. therapeutic activity.
摘要翻译： 本发明涉及一种合成模板分子的方法。 在本发明的一个方面，模板分子连接到模板，其模板化其合成。 该内容允许生成可以被筛选的文库。 治疗活动。
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