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公开(公告)号：US20060062789A1
公开(公告)日：2006-03-23
申请号：US11266444
申请日：2005-11-04
申请人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
发明人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
IPC分类号： C07K16/24 , A61K39/395 , G01N33/53
CPC分类号： C07K14/70575 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K16/2875 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
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公开(公告)号：US20050255532A1
公开(公告)日：2005-11-17
申请号：US11054515
申请日：2005-02-10
申请人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
发明人： Steven Ruben , Steven Barash , Gil Choi , Tristan Vaughan , David Hilbert
CPC分类号： C07K16/2875 , A61K35/12 , A61K47/6849 , A61K49/0004 , A61K2039/505 , C07K14/52 , C07K14/70575 , C07K2317/21 , C07K2317/622 , G01N33/5008 , G01N33/5011 , G01N33/5052 , G01N33/5091 , G01N33/564 , G01N33/574 , G01N33/68
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated vith aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
摘要翻译： 本发明涉及免疫特异性结合B淋巴细胞刺激物的抗体和相关分子。 本发明还涉及用于检测或诊断与异常B淋巴细胞刺激物表达相关的疾病或病症的方法和组合物，其包含抗体或其片段或变体，或免疫特异性结合B淋巴细胞刺激物的相关分子的B淋巴细胞刺激物的不适当功能。 本发明还涉及用于预防，治疗或改善与异常B淋巴细胞刺激物表达或不适当B淋巴细胞刺激因子功能相关的疾病或病症的方法和组合物，包括向动物施用有效量的一种或多种抗体或其片段或变体 或免疫特异性结合B淋巴细胞刺激物的相关分子。
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公开(公告)号：US20050032168A1
公开(公告)日：2005-02-10
申请号：US10896972
申请日：2004-07-23
申请人： Craig Rosen , George Komatsoulis , Kevin Baker , Charles Birse , Daniel Soppet , Henrik Olsen , Paul Moore , Ping Wei , Reinhard Ebner , D. Duan , Yanggu Shi , Gil Choi , Michele Fiscella , Jian Ni , Steven Ruben , Steven Barash
发明人： Craig Rosen , George Komatsoulis , Kevin Baker , Charles Birse , Daniel Soppet , Henrik Olsen , Paul Moore , Ping Wei , Reinhard Ebner , D. Duan , Yanggu Shi , Gil Choi , Michele Fiscella , Jian Ni , Steven Ruben , Steven Barash
IPC分类号： C12N15/09 , A61K31/00 , A61K31/7088 , A61K31/713 , A61K38/00 , A61K38/16 , A61K38/43 , A61K38/51 , A61K39/395 , A61K48/00 , A61P1/00 , A61P9/00 , A61P15/00 , A61P21/00 , A61P25/00 , A61P35/00 , A61P43/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/64 , C12N9/88 , C12N15/12 , C12N15/52 , C12N15/60 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/6424 , C12N2799/026 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20070020746A1
公开(公告)日：2007-01-25
申请号：US10807556
申请日：2004-03-24
申请人： Charles Kunsch , Gil Choi , Steven Barash , Patrick Dillon , Michael Fannon , Craig Rosen
发明人： Charles Kunsch , Gil Choi , Steven Barash , Patrick Dillon , Michael Fannon , Craig Rosen
CPC分类号： C12N15/1093 , A61K39/00 , C07K14/31 , C12N15/52
摘要： The present invention provides polynucleotide sequences of the genome of Staphylococcus aureus, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供金黄色葡萄球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US20050181439A1
公开(公告)日：2005-08-18
申请号：US11106649
申请日：2005-04-15
申请人： Gil Choi , Charles Kunsch , Steven Barash , Patrick Dillon , Brian Dougherty , Michael Fannon , Craig Rosen
发明人： Gil Choi , Charles Kunsch , Steven Barash , Patrick Dillon , Brian Dougherty , Michael Fannon , Craig Rosen
IPC分类号： G01N33/53 , A01K67/027 , A61K38/00 , A61K39/00 , A61K39/09 , A61K48/00 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N5/18 , C12N15/09 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/50 , G01N33/569 , G06F17/30 , C07H21/04 , C07K14/31 , C12N15/74
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
摘要翻译： 本发明涉及用于预防或减轻肺炎链球菌感染的新型疫苗。 本发明还涉及编码肺炎链球菌抗原多肽的分离的核酸分子。 还提供了抗原多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及在生物样品中检测链球菌核酸，多肽和抗体的诊断方法。
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公开(公告)号：US20070154986A1
公开(公告)日：2007-07-05
申请号：US11563552
申请日：2006-11-27
申请人： Charles Kunsch , Gil Choi , Patrick Dillon , Craig Rosen , Steven Barash , Michael Fannon , Brian Dougherty
发明人： Charles Kunsch , Gil Choi , Patrick Dillon , Craig Rosen , Steven Barash , Michael Fannon , Brian Dougherty
IPC分类号： C12P21/06 , C12N1/21 , C12N15/74 , C07H21/04 , C07K14/315
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US20050208602A1
公开(公告)日：2005-09-22
申请号：US10773236
申请日：2004-02-09
申请人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
发明人： Craig Rosen , Kevin Baker , Charles Birse , Gil Choi , Michele Fiscella , George Komatsoulis , Paul Moore , Jian Ni , Henrik Olsen , Steven Ruben , Ping Wei , D. Roxanne Duan , Yanggu Shi
IPC分类号： A61K38/00 , A61K38/17 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68
CPC分类号： G01N33/68 , A61K38/00 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/6845
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号：US20060073561A1
公开(公告)日：2006-04-06
申请号：US10986405
申请日：2004-11-12
申请人： Craig Rosen , Steven Ruben , Henrik Olsen , Kevin Baker , Michele Fiscella , Ping Wei , Charles Birse , George Komatsoulis , Gil Choi , Paul Moore , Ram Gupta , Yanggu Shi
发明人： Craig Rosen , Steven Ruben , Henrik Olsen , Kevin Baker , Michele Fiscella , Ping Wei , Charles Birse , George Komatsoulis , Gil Choi , Paul Moore , Ram Gupta , Yanggu Shi
摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗与所述人分泌蛋白相关的疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。
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公开(公告)号：US20050214786A1
公开(公告)日：2005-09-29
申请号：US10921235
申请日：2004-08-19
申请人： Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
发明人： Charles Birse , George Komatsoulis , Gil Choi , Henrik Olsen , Jian Ni , Kevin Baker , Craig Rosen , Steven Ruben , Michele Fiscella , Paul Moore , Ping Wei
CPC分类号： C07H21/04 , C07K14/47 , C12Q1/6883
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050149787A1
公开(公告)日：2005-07-07
申请号：US10910759
申请日：2004-08-02
申请人： Gil Choi , Kyou Lee , Dong Je , Jaewoo Park
发明人： Gil Choi , Kyou Lee , Dong Je , Jaewoo Park
CPC分类号： H04L12/66
摘要： Provided are an apparatus and method for testing call processing performance and conformance of a media gateway controller and a media gateway with respect to a media gateway control (MEGACO) protocol. The method includes generating a predetermined scenario regarding a test of call processing performance of a media gateway controller or a media gateway; selecting a function of the media gateway controller or the media gateway and emulating virtual analog lines between the media gateway controller and the media gateway according to the scenario; and testing the call processing performance of the media gateway controller or the media gateway using the virtual analog lines and the selected media gateway controller or the media gateway. Accordingly, it is possible to effectively test the call processing performance of the media gateway controller or a media gateway without test equipment.
摘要翻译： 提供了一种用于测试关于媒体网关控制（MEGACO）协议的媒体网关控制器和媒体网关的呼叫处理性能和一致性的装置和方法。 该方法包括产生关于媒体网关控制器或媒体网关的呼叫处理性能测试的预定场景; 选择媒体网关控制器或媒体网关的功能，并根据场景模拟媒体网关控制器和媒体网关之间的虚拟模拟线路; 以及使用虚拟模拟线路和所选择的媒体网关控制器或媒体网关测试媒体网关控制器或媒体网关的呼叫处理性能。 因此，无需测试设备即可有效地测试媒体网关控制器或媒体网关的呼叫处理性能。
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