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公开(公告)号：US20220017530A1
公开(公告)日：2022-01-20
申请号：US17475733
申请日：2021-09-15
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61P1/10 , A61K31/4355
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US10519110B2
公开(公告)日：2019-12-31
申请号：US16175144
申请日：2018-10-30
发明人： Yasutomi Asano , Takuto Kojima , Osamu Kurasawa , Tzu-Tshin Wong , Yasuhiro Hirata , Naoki Iwamura , Bunnai Saito , Yuta Tanaka , Ryosuke Arai , Shinichi Imamura , Kazuko Yonemori , Yasufumi Miyamoto , Shuji Kitamura , Osamu Sano
IPC分类号： C07D211/58 , C07F9/6509 , C07D401/14 , A61K31/437 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4468 , A61K31/451 , A61K31/452 , A61K31/4709 , A61K31/498 , A61K31/506 , A61K31/517 , A61K31/5355 , A61K31/661 , A61K33/22 , C07D215/42 , C07D401/06 , C07D401/12 , C07D409/12 , C07D413/06 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C07F5/02 , A61P3/00 , A61P35/00 , C07B59/00 , C07D405/06 , C07D413/14
摘要： The present invention relates to a compound which can be useful for the treatment or prevention of SPT-related diseases including cancer and congenital diseases associated with sphingolipid accumulation (including Niemann-Pick disease).
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公开(公告)号：US12084436B2
公开(公告)日：2024-09-10
申请号：US17426971
申请日：2020-01-29
发明人： Masahiro Ito , Takeshi Yamamoto , Keiko Kakegawa , Hideyuki Sugiyama , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Osamu Kubo , Akinori Toita , Takuto Kojima , Fumiaki Kikuchi , Minoru Sasaki , Misaki Homma , Yasuhiro Imaeda , Hironobu Maezaki , Shiinobu Sasaki , Ayumu Sato , Hirotaka Kamitani , Yasutomi Asano , Hironori Kokubo , Masato Yoshikawa
IPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
CPC分类号： C07D413/10 , C07D271/06 , C07D413/14 , C07D417/14
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound.
The present invention relates to a compound represented by the formula (I):
wherein each symbol is as described in the description, or a salt thereof.-
公开(公告)号：US11236099B2
公开(公告)日：2022-02-01
申请号：US16622632
申请日：2018-06-19
发明人： Kazuaki Takami , Masaki Seto , Shinobu Sasaki , Haruhi Ando , Masaki Ogino , Tomoko Ohashi , Toshihiro Imaeda , Ikuo Fujimori , Yasuhiro Tsukimi , Masami Yamada , Kenichiro Shimokawa , Takeshi Wakabayashi , Masataka Murakami , Makoto Fushimi , Tomohiro Okawa , Jinichi Yonemori , Tomohiro Ohashi , Hideo Suzuki , Hironobu Maezaki , Ayumu Sato , Yasutomi Asano , Steve Swann
IPC分类号： C07D491/048 , A61K31/4355 , A61P1/10
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the following formula (I): wherein each symbol is as described in the specification, or a salt thereof.
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公开(公告)号：US08778934B2
公开(公告)日：2014-07-15
申请号：US13774635
申请日：2013-02-22
发明人： Masakuni Kori , Toshihiro Imaeda , Shinji Nakamura , Masashi Toyofuku , Eiji Honda , Yasutomi Asano , Osamu Ujikawa , Michiyo Mochizuki
IPC分类号： A61K31/542
CPC分类号： C07D513/04
摘要： Provided is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor potentiating action. The compound of the present invention is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and the like.
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公开(公告)号：US10696651B2
公开(公告)日：2020-06-30
申请号：US16323863
申请日：2017-08-09
发明人： Jun Fujimoto , Xin Liu , Osamu Kurasawa , Terufumi Takagi , Douglas Robert Cary , Hiroshi Banno , Yasutomi Asano , Takuto Kojima
IPC分类号： C07D401/12 , C07D403/12 , C07D401/14 , C07D213/75 , C07D405/12 , C07D239/42 , C07D241/12 , C07D471/04 , C07D498/04 , C07D213/65 , A61P35/00 , C07D241/20 , C07D213/73 , A61K31/53 , A61K31/505 , A61K31/4406 , A61K31/444 , A61K31/4965 , C07D213/68 , C07D213/42 , A61K31/506 , A61K31/497 , A61K31/4375 , C07D239/20 , A61P43/00 , A61K31/5383 , A61K31/437 , A61K31/44 , C07D253/06 , C07D231/12 , C07D239/30 , C07D239/34 , C07D239/48 , C07D253/07 , C07D409/12 , C07D487/04
摘要： Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US11970483B2
公开(公告)日：2024-04-30
申请号：US17280633
申请日：2019-09-27
发明人： Shinobu Sasaki , Yasutomi Asano , Kazuaki Takami , Masaki Seto , Haruhi Ando
IPC分类号： C07D405/14 , A61P1/10 , C07D407/12 , C07D407/14 , C07D413/14 , C07D417/14
CPC分类号： C07D405/14 , A61P1/10 , C07D407/12 , C07D407/14 , C07D413/14 , C07D417/14
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I):
wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl group, or an optionally substituted C1-6 alkoxy group; and ring A is an optionally further substituted ring, or a salt thereof.-
公开(公告)号：US11279713B2
公开(公告)日：2022-03-22
申请号：US16827316
申请日：2020-03-23
发明人： Masakuni Kori , Toshihiro Imaeda , Shinji Nakamura , Masashi Toyofuku , Eiji Honda , Yasutomi Asano , Osamu Ujikawa , Michiyo Mochizuki
IPC分类号： C07D513/04
摘要： Provided is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof, which has an AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor potentiating action. The compound of the present invention is useful as a prophylactic or therapeutic drug for depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and the like.
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公开(公告)号：US12012419B2
公开(公告)日：2024-06-18
申请号：US17280634
申请日：2019-09-27
发明人： Shinobu Sasaki , Yasutomi Asano , Hironobu Maezaki , Ayumu Sato
IPC分类号： C07D498/04 , A61P1/00
CPC分类号： C07D498/04 , A61P1/00
摘要： The present invention aims to provide a compound that may be useful for the prophylaxis or treatment of constipation and the like. The present invention provides a compound represented by the formula (I):
wherein each symbol is as described in the specification, or a salt thereof.-
公开(公告)号：US10435399B2
公开(公告)日：2019-10-08
申请号：US16049359
申请日：2018-07-30
发明人： Masahiro Ito , Hideyuki Sugiyama , Osamu Kubo , Fumiaki Kikuchi , Takeshi Yasui , Keiko Kakegawa , Zenichi Ikeda , Tohru Miyazaki , Yasuyoshi Arikawa , Tomohiro Okawa , Jinichi Yonemori , Akinori Toita , Takuto Kojima , Yasutomi Asano , Ayumu Sato , Hironobu Maezaki , Shinobu Sasaki , Hironori Kokubo , Misaki Homma , Minoru Sasaki , Yasuhiro Imaeda
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14 , C07D487/04 , A61P25/28 , C07D471/04
摘要： The present invention provides a heterocyclic compound having a HDAC inhibitory action, and useful for the treatment of central nervous system diseases including neurodegenerative disease, and the like, and a medicament comprising the compound.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
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