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    Fluorochemical liquid augmented cryosurgery
    3.
    发明授权
    Fluorochemical liquid augmented cryosurgery 失效
    氟化学液体增加冷冻手术

    公开(公告)号：US5741248A

    公开(公告)日：1998-04-21

    申请号：US487386

    申请日：1995-06-07

    申请人： Robert G. Stern ,  Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Robert G. Stern ,  Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61B18/00 ,  A61B18/02 ,  A61B19/00 ,  A61B17/36

    CPC分类号： A61B18/0218 ,  A61B18/02 ,  A61B2018/00101 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3933 ,  A61B2218/002

    摘要： A method for cryogenic treatment of a lesion which includes the steps of delivering a fluorochemical liquid to the lesion, placing at least one cryoprobe into the lesion, and circulating cryogenic fluid through the cryoprobe, the cryogenic fluid causing an ice ball to form in a vicinity around the cryoprobe, wherein the ice ball obliterates at least a portion of the lesion. The fluorochemical liquid is utilized to augment the cryosurgical procedure and is perfused or injected into and/or around the lesioned site prior and/or during the application of a cryoprobe to the site. In one embodiment of the invention, the fluorochemical liquid acts as a contrast agent to enhance real-time medical imaging of the lesioned area and modifies the environment in and around the lesioned area. In another embodiment of the invention, the fluorochemical liquid augments cryosurgical procedures by controlling the size and shape of ice balls formed during the cryosurgical procedures. In this embodiment, a fluorochemical liquid with a properly chosen thermal conductivity and freezing point is utilized. Depending on the thermal properties chosen, the liquid either augments freezing of the target area and/or promotes thermal conduction to freeze larger areas, or limits the freezing of the target area and reduces thermal conduction. In a non-cryoprobe embodiment, the liquid is cooled to a temperature below the freezing point of the biological tissue. The cooled liquid is then infused into or around the cystic lesion to produce ablation.

    摘要翻译： 一种用于对病变进行低温处理的方法，包括以下步骤：将含氟化学液体输送到损伤部分，将至少一个冷冻探针放入损伤部分，并使低温液体循环通过冷冻探针，使低温流体在附近形成冰球 围绕冷冻探针，其中冰球消除至少一部分病变。 使用含氟化合物液体来增加冷冻手术的程序，并且在使用冷冻探针之前和/或期间向该部位灌注或注入损伤部位和/或周围。 在本发明的一个实施方案中，含氟化合物液体用作造影剂，以增强损伤区域的实时医学成像并改变损伤区域内和周围的环境。 在本发明的另一个实施方案中，含氟化合物通过控制在冷冻手术过程中形成的冰球的尺寸和形状而增加了冷冻手术。 在该实施例中，利用具有适当选择的导热性和凝固点的含氟化合物液体。 根据所选择的热性质，液体或者增加目标区域的冷冻和/或促进热传导以冻结较大的区域，或限制目标区域的冷冻并减少热传导。 在非冷冻探针实施方案中，将液体冷却至低于生物组织凝固点的温度。 然后将冷却的液体注入囊性病变中或周围，以产生消融。

    Thoracic Stabilizer
    6.
    发明申请
    Thoracic Stabilizer 有权
    胸部稳定剂

    公开(公告)号：US20090020129A1

    公开(公告)日：2009-01-22

    申请号：US12083253

    申请日：2006-10-18

    申请人： Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61G15/00 ,  A61B5/08 ,  A61B5/103

    CPC分类号： A61H31/006 ,  A61H31/008 ,  A61H2201/018 ,  A61H2201/5007 ,  A61H2201/5061

    摘要： A thoracic stabilizer for limiting anterior chest wall collapse includes a platform supporting a patient and a pair of lateral supports contacting opposite sides of the patient's chest wall and applying force to limit collapse of the chest wall. The force applied by the lateral supports is varied depending on the force applied to the platform by the patient. The stabilizer includes a retractometer measuring the collapse of the chest wall. According to one embodiment, the stabilizer includes a controller that varies the force applied to the chest wall in closed-loop fashion based on the chest wall collapse measured by the retractometer using an algorithm of the controller. According to one embodiment, the stabilizer includes motors moving the lateral supports. According to another embodiment, the stabilizer includes a hydraulic system and the lateral supports include expandable fluid-filled members.

    摘要翻译： 用于限制前胸壁塌陷的胸部稳定器包括支撑患者的平台和与患者胸壁的相对侧接触并且施加力以限制胸壁塌陷的一对侧向支撑件。 由侧向支撑施加的力根据患者施加到平台的力而变化。 稳定器包括测量胸壁塌陷的收缩计。 根据一个实施例，所述稳定器包括控制器，所述控制器使用所述控制器的算法，以闭环方式改变施加到所述胸壁的力，所述控制器基于由所述收缩计测量的所述胸壁塌陷。 根据一个实施例，稳定器包括移动横向支撑件的马达。 根据另一个实施例，稳定器包括液压系统，并且侧向支撑件包括可膨胀流体填充构件。

    Extrathoracic augmentation of the respiratory pump
    8.
    发明授权
    Extrathoracic augmentation of the respiratory pump 有权

    公开(公告)号：US09687415B2

    公开(公告)日：2017-06-27

    申请号：US13107208

    申请日：2011-05-13

    申请人： Tariq Rahman ,  Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Tariq Rahman ,  Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61H31/00 ,  A61H9/00 ,  A61H31/02

    CPC分类号： A61H31/00 ,  A61H9/0071 ,  A61H31/02 ,  A61H2201/107 ,  A61H2201/5002 ,  A61H2201/5097 ,  A61H2230/045 ,  A61H2230/207 ,  A61H2230/425

    摘要： Systems and methods for assisting respiration extrathoracically, particularly useful for augmenting respiration in neonatal patients, including providing a positive pressure to a torso area of a patient. The positive pressure may be delivered to the torso area of the patient while the torso area is exposed to an ambient pressure, such as by providing positive pressure with high frequency gas jets that are positioned in proximity to the torso area. The positive pressure may be delivered to different parts of the torso area of the patient at different times, such as by controlling gas jets independently. The positive pressure may also be controlled in coordination with a gas flow and concentration to the patient's airway, such as by increasing the positive pressure as a gas flow pressure delivered to the patient's airway is reduced. The gas flow to the patient's airway may be provided by, for example, a high-flow nasal cannula (HFNC) mechanism or a continuous positive airway pressure (CPAP) mechanism that is controlled in coordination with the positive pressure based upon a desired respiratory function of the patient. The control of the gas flow and the positive pressure may be based on an input of patient monitored parameters and/or calculated values based on the patient monitored parameters.

    Process for transient and steady state delivery of biological agents to the lung via breathable liquids
    9.
    发明授权
    Process for transient and steady state delivery of biological agents to the lung via breathable liquids 有权
    通过透气液体暂时和稳态地将生物制剂递送到肺的过程

    公开(公告)号：US08375943B2

    公开(公告)日：2013-02-19

    申请号：US13050027

    申请日：2011-03-17

    申请人： Thomas H. Shaffer ,  Marla R. Wolfson

    发明人： Thomas H. Shaffer ,  Marla R. Wolfson

    IPC分类号： A61M16/00 ,  A61M16/10 ,  A61M15/00 ,  A61M11/00

    CPC分类号： A61M16/0054 ,  A61M16/22 ,  A61M2202/0476

    摘要： The present invention includes a transient method of delivering a biological agent in a breathable liquid to a lung of a patient. The present invention includes a steady state method of delivering a biological agent in a breathable liquid to a lung of a patient. The steps of both the transient delivery method and the steady state delivery method can be controlled by a servo-control unit. A supplementary biological agent delivery step can be performed in both the transient method of delivering a biological agent and the steady state method of delivering a biological agent.

    摘要翻译： 本发明包括将透气液体中的生物剂递送到患者的肺的瞬时方法。 本发明包括将透气液体中的生物剂递送到患者的肺的稳态方法。 瞬时输送方式和稳态输送方法两者的步骤可以由伺服控制装置控制。 可以在递送生物剂的瞬时方法和递送生物制剂的稳态方法两者中进行补充生物剂递送步骤。