公开(公告)号：US4241563A

公开(公告)日：1980-12-30

申请号：US70921

申请日：1979-08-30

申请人： Werner Muller ,  Hans Heinzer

发明人： Werner Muller ,  Hans Heinzer

IPC分类号： B65B39/04 ,  B65B31/04 ,  B65B9/08

CPC分类号： B65B39/04

摘要： A heat-sealable foil is shaped around a shaping pipe to form a tube and during removal from the shaping pipe is provided with transverse seams by means of transverse heating jaws. The resulting bags are filled by means of a fill pipe and a dosaging worm or auger. A conduit leads from the lower end of the shaping pipe to a bellows and to a bottle of protective gas. The bellows forms a closed chamber whose volume is periodically increased and reduced in the operating rhythm of the bag forming apparatus by means of drive members. Thus the pressure conditions at the end of the shaping pipe can be influenced periodically, so as to avoid that the filled or sealed bags contain undesirable air inclusions or, when filling under protective gas, so as to avoid greater losses of protective gas from leaking into the open air.

摘要翻译： 可热密封的箔形成在成形管周围以形成管，并且在从成形管移除期间通过横向加热爪设置横向接缝。 所得到的袋子通过填充管和剂量蠕虫或螺旋钻来填充。 导管从成形管的下端引导到波纹管和一瓶保护气体。 波纹管形成封闭的腔室，其体积通过驱动构件在袋形成装置的操作节奏中周期性地增加和减小。 因此，可以定期影响成形管端部的压力条件，以避免填充或密封的袋子含有不期望的空气夹杂物，或者在保护气体下填充时，以避免更大的保护气体泄漏损失 露天。

公开(公告)号：US4215520A

公开(公告)日：1980-08-05

申请号：US959226

申请日：1978-11-09

申请人： Hans Heinzer ,  Werner Muller

发明人： Hans Heinzer ,  Werner Muller

IPC分类号： B65B9/20 ,  B65B9/08 ,  B65B43/42

CPC分类号： B65B61/28 ,  B65B43/39 ,  B65B9/2042 ,  B65B9/2049 ,  B65B9/213 ,  B65B2220/18

摘要： An apparatus for making, filling, closing and boxing bags includes a vertically oriented hollow mandrel about which a hose of sealable sheet is continuously formed, a device for cylindrically providing a transverse seam on the hose; a cutting device for cyclically severing the hose at the transverse seam for providing precedingly filled, sealed bags; a base plate situated underneath the mandrel for supporting thereon serially positioned and advanced, upright-oriented bag-receiving boxes open at their top and bottom; an opening provided in the base plate and aligned with the mandrel; and a vertically displaceably supported bag grasping device for penetrating through the opening into a box positioned underneath the mandrel and for downwardly pulling a filled and closed bag into the box.

摘要翻译： 用于制造，填充，关闭和装箱的装置包括垂直定向的中空心轴，可密封片材的软管连续地围绕在该心轴上，用于在软管上圆柱形地提供横向接缝的装置; 切割装置，用于在横缝处循环切断软管，以提供先前填充的密封袋; 位于心轴下方的基板，用于支撑在其顶部和底部上开放的串联定位和前进的直立定向的袋接收盒; 设置在基板中并与心轴对准的开口; 以及一个可垂直移动的支撑袋抓取装置，用于穿过开口进入定位在心轴下方的盒子中，并将填充和封闭的袋子向下拉入箱中。

公开(公告)号：US4129976A

公开(公告)日：1978-12-19

申请号：US835426

申请日：1977-09-21

申请人： Bruno Grundler ,  Hans Heinzer ,  Werner Muller

发明人： Bruno Grundler ,  Hans Heinzer ,  Werner Muller

IPC分类号： B65B9/12

CPC分类号： B65B9/2042 ,  B29C65/18 ,  B29C65/7451 ,  B29C66/0342 ,  B29C66/1122 ,  B29C66/349 ,  B29C66/4312 ,  B29C66/81427 ,  B29C66/81431 ,  B29C66/81812 ,  B29C66/83543 ,  B29C66/8491 ,  B65B37/10 ,  B65B39/002 ,  B65B9/213 ,  B29C2035/1666 ,  B29C53/48 ,  B29C65/305 ,  B29C66/71 ,  B29C66/81415 ,  B29K2023/06 ,  B29K2101/12 ,  B29L2031/7128 ,  B29L2031/7166 ,  B65B9/2007 ,  Y10S493/936

摘要： An apparatus for forming, filling and closing bags has a hollow mandrel on which a hose is continuously formed from a sheet; two vertically reciprocating and horizontally oppositely movable shoes underneath the mandrel for cyclically pressing together a first hose portion and providing a transverse seam thereacross as the hose and the shoes move downwardly in unison; a folding device cyclically forming bottom flaps from a second hose portion at opposite sides of the hose at the lower end of the mandrel above the first hose portion; a clamping device for firmly grasping the hose at the second hose portion and backing the bottom flaps along the entire hose cross section as it pulls the hose downwardly from the mandrel while moving simultaneously downwardly with the shoes and while the hose part that terminates at the bottom flaps is being filled with goods by gravity; and a cutting device for cutting through the transverse seam when the shoes and the clamping device have pulled the hose to a predetermined low position for severing a previously filled hose portion as a separated, sealed bag from the upstream, still coherent hose.

摘要翻译： 用于形成，填充和关闭袋的装置具有中空心轴，软管从其上连续形成; 在心轴下方的两个垂直往复和水平相对移动的鞋子，用于循环地将第一软管部分压合在一起，并且在软管和鞋子一致地向下移动时提供横向缝; 折叠装置，在第一软管部分上方的心轴的下端处，在软管的相对侧处的第二软管部分周期性地形成底部折翼; 夹紧装置，用于在第二软管部分处牢固地抓住软管并且沿着整个软管横截面沿着整个软管横截面背衬底板，当软管同时向下移动时从软管向下拉动软管，同时在底部终止的软管部分 襟翼由于重力被充满货物; 以及切割装置，用于当鞋和夹紧装置将软管拉到预定的低位置时切割穿过横缝，用于将先前填充的软管部分作为分离的密封袋与上游的相干软管分开。

公开(公告)号：US4056045A

公开(公告)日：1977-11-01

申请号：US719057

申请日：1976-08-30

申请人： Hans Heinzer ,  Werner Muller

发明人： Hans Heinzer ,  Werner Muller

IPC分类号： B31B3/00 ,  B65B43/10 ,  B31B1/86

CPC分类号： B65B43/10

摘要： An elongate panel of a flexible sheet material which is not heat-sealable is formed into a succession of bags by advancing the panel in the direction of its length between a rectangular shaping tube and a folding box to form the panel into a tubular structure of rectangular cross section, applying a bead of adhesive material along one longitudinal edge of the panel and bringing the other longitudinal edge thereof against the adhesive to form a longitudinal seam, applying a bead of adhesive material to one narrow side and both wide sides of the tubular structure in the region defining the bottom of each bag to cause this bead to have the form of a U in a plane lying perpendicular to the length of the tubular structure, severing the tubular structure just downstream of each U-shaped bead, and forming the bottom of each bag by first folding in successive narrow sides of the tubular structure adjacent the associated line of severance, to give the wide sides the form of triangular ears each composed of two layers of sheet material, and then folding successive ears in against the folded narrow sides, the folded narrow sides being joined together, the layers of each ear being joined together, and the ears being joined to one another and to the folded narrow sides by respective portions of the U-shaped adhesive bead.

摘要翻译： 不可热封的柔性片状材料的细长板通过在长方形成形管和折叠箱之间沿其长度方向前进而将板形成为一系列袋，以将板形成为矩形的管状结构 横截面，沿着面板的一个纵向边缘施加粘合剂材料珠，并使另一个纵向边缘抵靠粘合剂以形成纵向接缝，将粘合剂材料珠施加到管状结构的一个窄侧和两个宽侧 在限定每个袋的底部的区域中，使得该胎圈在垂直于管状结构的长度的平面中具有U形式，将管状结构切断在每个U形胎圈的正下方，并形成底部 通过首先将管状结构的连续窄边折叠在相邻的切断线上，以使宽边形成三角形耳朵的形状 由两层片材组成，然后将连续的耳朵折叠在折叠的窄边上，折叠的窄边连接在一起，每个耳朵的层被连接在一起，并且耳朵彼此接合并且被折叠成狭窄的 侧面由U形粘合剂珠的各个部分。

公开(公告)号：US09108618B2

公开(公告)日：2015-08-18

申请号：US13805358

申请日：2011-06-27

申请人： Werner Muller

发明人： Werner Muller

IPC分类号： B60W10/02 ,  B60K23/04 ,  B60K17/16 ,  B60W10/115 ,  B60W30/18 ,  F16H48/10

CPC分类号： B60W10/023 ,  B60K17/165 ,  B60K23/04 ,  B60W10/115 ,  B60W30/18145 ,  B60W2540/18 ,  B60W2720/28 ,  B60W2720/406 ,  B60Y2200/22 ,  B60Y2200/41 ,  F16H48/10

摘要： A gearbox arrangement (1), which is arranged in a drive train of a multi-axle land vehicle (2), in particular a commercial vehicle, or a similar means of transportation, wherein at least one of said axles is driven, wherein at least one planetary drive (8) is associated with each of the axle halves (5) of a driven axle. The gearbox arrangement comprises at least one sensor device (7) for detecting a steering manipulation on the vehicle (2) and a control device (6). In order to have a gearbox arrangement (1) available that establishes a reliable, simply designed connection between the drive motor and driven wheels (4) with little effort and enables reliable control of the particular wheels (4) in regard to rotational speed and torque during drive and during deceleration, and thus realizes a controllable rotational speed compensation during cornering and significantly reduces the diameter and the constructed size of the power-split gearbox in particular for vehicles (2) having a high axle torque, the axle halves (5) are driven synchronously without differential and the control device (6) is provided with a hydrostatic device (11) that can be manipulated, by which hydrostatic device each of the wheels (4) rolling without slip maintains its torque.

摘要翻译： 一种齿轮箱装置（1），其布置在多轴陆地车辆（2）的传动系中，特别是商用车辆或类似的运输工具，其中至少一个所述车轴被驱动，其中在 至少一个行星驱动器（8）与从动轴的每个轴半部（5）相关联。 齿轮箱装置包括用于检测车辆（2）上的转向操纵的至少一个传感器装置（7）和控制装置（6）。 为了具有可用的齿轮箱装置（1），其能够以很小的努力在驱动马达和从动轮（4）之间建立可靠的，简单设计的连接，并且能够相对于转速和扭矩可靠地控制特定的车轮（4） 在驱动期间和减速期间，因此在转弯期间实现可控的转速补偿，并且显着地减小动力分配齿轮箱的直径和结构尺寸，特别是具有高轴转矩的车辆（2），轴半部（5） 在没有差速器的情况下同步地被驱动，并且控制装置（6）设置有可被操纵的静液压装置（11），通过该静液压装置，每个车轮（4）滚动而不滑动地保持其扭矩。

公开(公告)号：US20080120733A1

公开(公告)日：2008-05-22

申请号：US11629709

申请日：2005-06-16

申请人： Martin Hafner ,  Karina Nawrath ,  Werner Muller

发明人： Martin Hafner ,  Karina Nawrath ,  Werner Muller

IPC分类号： A01K67/027 ,  C12N15/87 ,  C12N5/02 ,  C12N5/00 ,  C12N5/04 ,  A01H1/00 ,  C12N15/00

CPC分类号： C12N15/8218 ,  C12N15/63 ,  C12N15/8209 ,  C12N15/821

摘要： The invention relates to a method for the production of a eukaryotic cell selectable by inactivation or reduction of an endogenous gene function, comprising the steps of (a) introduction of one or more vectors into the cell and (b) expression of a siRNA and preferably shRNA coded by the one or more vectors, directed against an endogenous selectable gene and inactivating same, said siRNA or shRNA being the transcription product of an RNAi selection cassette, the selection cassette comprising a section of at least 19 nucleotides of the transcribed region of the gene, said selection being operatively linked to a promoter and a transcription termination signal. Furthermore, the invention relates to a eukaryotic cell comprising an RNAi selection cassette which is directed against an endogenous selectable gene and inactivates the function of said gene; wherein the RNAi selection cassette comprises a section of the gene with a length of at least 19 nucleotides which is operatively linked to a promoter and a transcription termination signal. Moreover, the invention relates to methods for the production of a transgenic mammal, comprising the steps: (a) injection of the embryonic stem cell according to the invention or of an embryonic stem cell selected according to the method of the invention in blastocysts of a mammal, (b) transfer of the blastocysts into the uterus of a mammal, and (c) carrying the transgenic mammal to full term. Finally, the invention relates to a method for the production of a transgenic plant.

摘要翻译： 本发明涉及通过灭活或还原内源基因功能来选择性地生产真核细胞的方法，其包括以下步骤：（a）将一种或多种载体导入细胞，和（b）表达siRNA，优选 由一个或多个载体编码的针对内源可选择基因并使其失活的shRNA，所述siRNA或shRNA是RNAi选择盒的转录产物，所述选择盒包含至少19个核苷酸的转录区的部分 基因，所述选择可操作地连接到启动子和转录终止信号。 此外，本发明涉及包含针对内源可选择基因并使所述基因的功能失活的RNAi选择盒的真核细胞; 其中所述RNAi选择盒包含长度为至少19个核苷酸的基因的一部分，其与启动子和转录终止信号有效连接。 此外，本发明涉及生产转基因哺乳动物的方法，其包括以下步骤：（a）根据本发明的胚胎干细胞或根据本发明的方法选择的胚胎干细胞在囊胚中的注射 哺乳动物，（b）将囊胚转移到哺乳动物的子宫中，和（c）将转基因哺乳动物全部携带。 最后，本发明涉及生产转基因植物的方法。

公开(公告)号：US20070172421A1

公开(公告)日：2007-07-26

申请号：US11569164

申请日：2005-05-27

申请人： Werner Muller ,  Joachim Nozulak ,  Bernard Roy ,  Dominik Feuerbach

发明人： Werner Muller ,  Joachim Nozulak ,  Bernard Roy ,  Dominik Feuerbach

IPC分类号： A61K51/00 ,  A61K31/4709 ,  A61K31/454 ,  C07D417/14 ,  C07D403/14

CPC分类号： C07D207/26 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/14

摘要： The invention relates to compounds of formula (I) Wherein R1, R2, R3, R4 and n are as defined in the specification, to processes for their manufacture, to their use as pharmaceuticals, in diagnosis, as PET ligands and to pharmaceutical or diagnostic compositions comprising such compounds.

摘要翻译： 本发明涉及式（I）的化合物，其中R 1，R 2，R 3，R 4， 和n如说明书中所定义的，其制备方法，作为药物用作诊断用作PET配体，以及包含这些化合物的药物或诊断组合物。

公开(公告)号：US20060029939A1

公开(公告)日：2006-02-09

申请号：US10530240

申请日：2003-10-02

申请人： Werner Muller ,  Heinz Schroder ,  Anatoli Krasko

发明人： Werner Muller ,  Heinz Schroder ,  Anatoli Krasko

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/16 ,  C12N15/74

CPC分类号： C12N9/88 ,  C12P3/00

摘要： Silicatein is an enzyme of silicate-forming organisms used for the synthesis of their silicate scaffold. The present invention relates to the use of highly-expressed and highly active recombinant silicatein, silicatein isolated from natural sources after gene induction as well as silicatein-fusion proteins for the synthesis of amorphous silicon dioxide (silicic acids and silicates), siloxanes as well as modification of these compounds and their technical use.

摘要翻译： 硅酸盐是一种用于合成硅酸盐支架的硅酸盐形成生物的酶。 本发明涉及在基因诱导后从天然来源分离的高表达和高活性的重组硅酸蛋白，硅酸盐以及用于合成无定形二氧化硅（硅酸和硅酸盐），硅氧烷的硅酸盐融合蛋白以及硅氧烷 - 这些化合物的改性及其技术用途。

公开(公告)号：US5657128A

公开(公告)日：1997-08-12

申请号：US670772

申请日：1996-06-24

申请人： Werner Muller ,  Joachim Luber

发明人： Werner Muller ,  Joachim Luber

IPC分类号： A61B90/20 ,  G01B9/04 ,  G02B21/00 ,  G02B21/22 ,  G02B21/36 ,  G01B11/14 ,  G01N21/00 ,  H04N7/18

CPC分类号： G01B9/04 ,  G02B21/0012 ,  G02B21/22 ,  G02B21/361 ,  A61B90/10 ,  A61B90/20

摘要： A defined determination of the field of view observed through a surgical microscope is made. To achieve this determination, the relative current position of the plane of the field of view to the position of an object detail of interest is detected in a sighting method with the aid of a position detection system operating according to the laser triangulation principle. As soon as the plane of the field of view and the object detail are coincident, then with the aid of detected optical system data, the position of the object detail with reference to the surgical microscope is determined and, with the detected coordinates of the surgical microscope, the position of the field of view is determined in space. The position detecting system required for this purpose operates on an optical basis and can be integrated into the optics of the surgical microscope.

摘要翻译： 进行通过手术显微镜观察到的视野的确定的确定。 为了实现该确定，借助于根据激光三角测量原理操作的位置检测系统，以瞄准方法来检测视场平面相对于感兴趣的物体细节的位置的相对当前位置。 一旦观察平面和物体细节一致，则借助于检测到的光学系统数据，确定参考手术显微镜的物体细节的位置，并且利用检测到的外科手术坐标 显微镜，视野的位置是在太空中确定的。 为此目的所需的位置检测系统在光学基础上运行，并且可以集成到手术显微镜的光学元件中。

公开(公告)号：US5345087A

公开(公告)日：1994-09-06

申请号：US11515

申请日：1993-02-01

申请人： Joachim Luber ,  Werner Muller ,  Martin Pelzer ,  Anette Reiss

发明人： Joachim Luber ,  Werner Muller ,  Martin Pelzer ,  Anette Reiss

IPC分类号： A61B17/00 ,  A61B34/00 ,  A61B34/20 ,  A61B90/50 ,  B25J13/00 ,  B25J19/02 ,  G02B21/24 ,  G01N21/86

CPC分类号： B25J13/00 ,  A61B34/74 ,  A61B90/50 ,  B25J19/021 ,  G02B21/24 ,  A61B2017/00694 ,  A61B2034/2055 ,  A61B2090/502 ,  A61B34/20 ,  A61B90/20

摘要： An instrument is mounted on a motorized positioning mechanism for providing a contactless guidance of the instrument. A transmitting unit and a receiving unit are arranged in a defined relative position to an operator and the instrument so that an evaluation unit positions the instrument via corresponding control signals with the aid of the registered signals of the receiving unit. A preferred application is the contactless guidance of a surgical microscope which tracks the head movements of the surgeon.

摘要翻译： 仪器安装在电动定位机构上，用于提供仪器的非接触式引导。 发送单元和接收单元被布置在与操作者和仪器的限定的相对位置中，使得评估单元借助于接收单元的登记信号经由相应的控制信号来定位乐器。 优选的应用是跟踪外科医生的头部运动的手术显微镜的非接触式引导。