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1.发明授权Pyridyl substituted benzothiazole compounds which have useful pharmaceutical utility 失效具有有用的药物效用的吡啶基取代的苯并噻唑化合物
公开(公告)号：US5300518A
公开(公告)日：1994-04-05
申请号：US861379
申请日：1992-03-31
申请人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
发明人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
IPC分类号： C07D277/82 , C07D417/06 , C07D417/12 , C07D277/62 , A61K31/41
CPC分类号： C07D417/06 , C07D277/82 , C07D417/12 , Y02P20/55
摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;R.sup.2 represents a hydrogen atom and;R.sup.5 and R.sup.6 are the same or different and each represent a hydrogen atom or a lower alkyl group; or a pharmacologically acceptable salt thereof.
摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能有效的疾病的预防或治疗剂的苯并噻唑衍生物或其药理学上可接受的盐。 由以下通式（I）表示的苯并噻唑衍生物：（*化学结构*）（I）其中R 1和R 3相同或不同，表示氢原子，低级烷基或低级烷氧基; R 4表示由式 - （CH x）-q表示的基团，其中q为1至4的整数; R2表示氢原子， R 5和R 6相同或不同，各自表示氢原子或低级烷基; 或其药理学上可接受的盐。
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公开(公告)号：US5635519A
公开(公告)日：1997-06-03
申请号：US388813
申请日：1995-02-15
申请人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
发明人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
IPC分类号： C07D277/82 , C07D417/06 , C07D417/12 , C07D401/02 , A61K31/44
CPC分类号： C07D417/06 , C07D277/82 , C07D417/12 , Y02P20/55
摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##
摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能的疾病有效的预防或治疗剂的权利要求中所定义的下式的苯并噻唑衍生物或其药理学上可接受的盐：
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3.发明授权Pyridyl substituted benzothiazole compounds which have useful pharmaceutical utility 失效具有有用的药物效用的吡啶基取代的苯并噻唑化合物
公开(公告)号：US5420144A
公开(公告)日：1995-05-30
申请号：US148914
申请日：1993-11-05
申请人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
发明人： Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Hirotoshi Numata , Naoki Kobayashi , Masanobu Shinoda , Tetsuya Kawahara , Manabu Murakami , Kiyoshi Oketani , Takashi Inoue , Takashi Yamanaka , Isao Yamatsu
IPC分类号： C07D277/82 , C07D417/06 , C07D417/12 , C07D417/04 , A61K31/41
CPC分类号： C07D417/06 , C07D277/82 , C07D417/12 , Y02P20/55
摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1##
摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能有效的疾病的预防或治疗剂的苯并噻唑衍生物或其药理学上可接受的盐。 由以下通式（I）表示的苯并噻唑衍生物：（I）
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公开(公告)号：US5210239A
公开(公告)日：1993-05-11
申请号：US576054
申请日：1990-08-31
申请人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
发明人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
IPC分类号： A61K31/16 , A61K31/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/16 , C07C45/00 , C07C47/575 , C07C50/38 , C07C51/09 , C07C59/54 , C07C59/58 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/82 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/16 , C07C69/734 , C07C69/738 , C07C235/30 , C07C235/78 , C07C255/31 , C07C255/41 , C07C255/53 , C07C255/57 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/60 , C07C323/62 , C07D211/46 , C07D213/55 , C07D265/30 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/46 , C07D295/18 , C07D295/185 , C07D309/04 , C07D309/06 , C07D333/24 , C07D521/00
CPC分类号： C07D295/185 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24 , C07C2101/14 , C07C2101/16
摘要： A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where R1 is selected from the group consisting of alkyl, alkenly, alkynyl or heterocycle, R2 is a substituted nitrogen containing radical wherein the substituents on said nitrogen are selected from the group consisting of hydrogen, substituted or unsubstituted lower alkyl or heterocycles, and where said nitrogen may be a ring heteroatom, and R3, R4 and R5, may be the same or different and each are hydrogen, lower alkyl or lower alkoxy groups.
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公开(公告)号：US5385942A
公开(公告)日：1995-01-31
申请号：US22688
申请日：1993-03-01
申请人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
发明人： Shinya Abe , Yasushi Okamoto , Katsuya Tagami , Shigeki Hibi , Junichi Nagakawa , Kazuo Hirota , Ieharu Hishinuma , Kaname Miyamoto , Takashi Yamanaka , Hiromitsu Yokohama , Tsutomu Yoshimura , Tohru Horie , Yasunori Akita , Koichi Katayama , Isao Yamatsu
IPC分类号： A61K31/16 , A61K31/00 , A61K31/19 , A61K31/215 , A61K31/255 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P1/00 , A61P1/16 , C07C45/00 , C07C47/575 , C07C50/38 , C07C51/09 , C07C59/54 , C07C59/58 , C07C59/64 , C07C59/68 , C07C59/72 , C07C59/82 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/16 , C07C69/734 , C07C69/738 , C07C235/30 , C07C235/78 , C07C255/31 , C07C255/41 , C07C255/53 , C07C255/57 , C07C317/24 , C07C317/44 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/60 , C07C323/62 , C07D211/46 , C07D213/55 , C07D265/30 , C07D277/20 , C07D277/22 , C07D277/24 , C07D277/30 , C07D277/46 , C07D295/18 , C07D295/185 , C07D309/04 , C07D309/06 , C07D333/24 , C07D521/00
CPC分类号： C07D295/185 , C07C255/31 , C07C255/41 , C07C255/57 , C07C317/46 , C07C323/55 , C07C323/56 , C07C323/62 , C07C45/00 , C07C47/575 , C07C50/38 , C07C59/54 , C07C59/68 , C07C59/90 , C07C65/21 , C07C66/00 , C07C69/734 , C07C69/738 , C07D211/46 , C07D213/55 , C07D277/30 , C07D277/46 , C07D309/04 , C07D333/24 , C07C2101/14 , C07C2101/16
摘要： A quinone derivative useful in the treatment of hepatic diseases defined by the general formula: ##STR1## where X and Y may be the same or different from each other and are each a hydroxyl group, a group represented by the formula --(--OCH.sub.2 --).sub.n --OR.sup.6, wherein n is 0 or 1 and R.sup.6 is a lower alkyl group, or an acyl group.
摘要翻译： 用于治疗由以下通式定义的肝脏疾病的醌衍生物：其中X和Y可以相同或不同，并且各自为羟基，由式表示的基团 - （ - OCH 2 - ）n-OR 6，其中n为0或1，R6为低级烷基或酰基。
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公开(公告)号：US5298649A
公开(公告)日：1994-03-29
申请号：US774237
申请日：1991-10-10
申请人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18 , C07C69/76
CPC分类号： C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要： A naphthalene derivative having the formula is new and useful for medicine. ##STR1## wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula, ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group.
摘要翻译： 具有该式的萘衍生物是新的并且可用于药物。 其中R 1表示氢原子，低级烷基或酰基; R2独立地表示氢原子，低级烷基，低级烷氧基，卤素原子，环烷基，环烷基烷基，羟基，可被取代的芳基，芳基可以被取代的芳基烷基 杂芳基或杂芳基烷基; R3和R4相同或不同，表示氢原子，低级烷基，低级烯基，可以具有取代基的芳基，芳基可以被取代的芳基烷基，芳基可以被取代的芳基烯基 烷氧基烷基，杂芳基，杂芳基烷基，羧基，羧基烷基，氨基烷基或氰基; R5表示式-OR7的基团（其中R7表示氢原子或低级烷基）或下式的基团，其中R8和R9相同或不同，表示氢原子 或低级烷基。
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公开(公告)号：US5134111A
公开(公告)日：1992-07-28
申请号：US451468
申请日：1989-12-15
申请人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18
CPC分类号： C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要： A naphthalene derivative having the formula is new and useful for medicine. ##STR1## [wherein R.sup.1 represents a hydrogen atom, a lower alkyl group or an acyl group;R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroarylalkyl group;R.sup.3 and R.sup.4 are the same or different and represent a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxy group, a carboxyalkyl group, an aminoalkyl group, or a cyano group;R.sup.5 represents a group of the formula, --OR.sup.7, (wherein R.sup.7 represents a hydrogen atom or a lower alkyl group), or a group of the formula ##STR2## (wherein R.sup.8 and R.sup.9 are the same or different and represent a hydrogen atom or a lower alkyl group, or R.sup.8 and R.sup.9 can form, along with the nitrogen atom bonded with R.sup.8 and R.sup.9, a ring which may contain an oxygen atom);R.sup.6 independently represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, an amino group, an arylalkyl group, or an aryl group; andm is 0 or an integer of from 1 to 2, and n is 0 or an integer of from 1 to 4.]
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公开(公告)号：US5527948A
公开(公告)日：1996-06-18
申请号：US402569
申请日：1995-03-13
申请人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
发明人： Makoto Okita , Hiroshi Shirota , Masayuki Tanaka , Toshihiko Kaneko , Katsuya Tagami , Shigeki Hibi , Yasushi Okamoto , Seiichiro Nomoto , Takeshi Suzuki , Kenichi Chiba , Masaki Goto , Ryoichi Hashida , Hideki Ono , Hideto Ohhara , Hideki Sakurai , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
IPC分类号： C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/30 , C07C45/51 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68 , C07C69/157 , C07F7/18 , C07C69/76 , C07C49/115
CPC分类号： C07F7/1852 , C07C39/225 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/298 , C07C45/30 , C07C45/305 , C07C45/513 , C07C45/54 , C07C45/59 , C07C45/63 , C07C45/71 , C07C47/57 , C07C47/575 , C07C49/83 , C07C49/84 , C07C59/68
摘要： Naphthalene derivatives of the formula: ##STR1## wherein R.sup.1, represents a hydrogen atom, a lower alkyl group or an acyl group; R.sup.2 independently represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a cycloalkyl group, a cycloalkylalkyl group, a hydroxyl group, an aryl group which may be substituted, an arylalkyl group whose aryl group may be substituted, a heteroaryl group, or a heteroaryllakyl group; R.sup.3 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, an aryl group which may have a substituent, an arylalkyl group whose aryl group may be substituted, an arylalkenyl group whose aryl group may be substituted, a cycloalkyl group, an alkoxyalkyl group, a heteroaryl group, a heteroarylalkyl group, a carboxyl group, a carboxyalkyl group, an aminoalkyl group, or a cyano group; R.sup.6 is C.sub.1-6 alkyl; and m is 0 or an integer of from 1 to 2 useful in treating autoimmune diseases are disclosed.
摘要翻译： 下式的萘衍生物：其中R 1，表示氢原子，低级烷基或酰基; R2独立地表示氢原子，低级烷基，低级烷氧基，卤素原子，环烷基，环烷基烷基，羟基，可被取代的芳基，芳基可以被取代的芳基烷基 ，杂芳基或杂芳基烷基; R 3表示氢原子，低级烷基，低级烯基，可以具有取代基的芳基，可以被取代芳基的芳基烷基，可以被芳基取代的芳基烯基，环烷基， 烷氧基烷基，杂芳基，杂芳基烷基，羧基，羧基烷基，氨基烷基或氰基; R6是C1-6烷基; 并且公开了m为0或可用于治疗自身免疫性疾病的1〜2的整数。
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公开(公告)号：US4888439A
公开(公告)日：1989-12-19
申请号：US729444
申请日：1985-05-01
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： C07D295/18 , A61K31/16 , A61K31/195 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P1/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/20 , C07C233/31 , C07C233/36 , C07C235/76 , C07D207/20 , C07D207/325 , C07D233/60 , C07D295/185 , C07D521/00
CPC分类号： C07D295/185 , C07D207/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： A novel polyprenyl compound is identified with the formula and useful for a pharmaceutical drag. ##STR1## wherein X represents a group of the formula: ##STR2## (wherein R.sup.1 and R.sup.2, which may be the same or different, represent each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group, or a lower alkenyl group); a group of the formula: ##STR3## (wherein A including the nitrogen atom shown represents a ring containing nitrogen and oxygen atoms); or a group of the formula: ##STR4## (wherein R.sup.3 represents a hydrogen atom or a lower alkyl group, and R.sup.4 represents a lower alkyl group); Y represents a group of the formula: ##STR5## or a group of the formula: ##STR6## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group), and n represents an integer of from 2 to 5.
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公开(公告)号：US4782151A
公开(公告)日：1988-11-01
申请号：US149706
申请日：1988-01-29
申请人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
发明人： Isao Yamatsu , Takeshi Suzuki , Shinya Abe , Kouji Nakamoto , Akiharu Kajiwara , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki
IPC分类号： C07D295/18 , A61K31/16 , A61K31/195 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/40 , A61K31/415 , A61K31/445 , A61K31/535 , A61K31/5375 , A61P1/04 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/05 , C07C233/09 , C07C233/18 , C07C233/20 , C07C233/31 , C07C233/36 , C07C235/76 , C07D207/20 , C07D207/325 , C07D233/60 , C07D295/185 , C07D521/00 , C07D265/30 , C07D233/00 , C07D239/00 , C07D295/00
CPC分类号： C07D295/185 , C07D207/20 , C07D231/12 , C07D233/56 , C07D249/08
摘要： A novel polyprenyl compound is identified with the formula and useful for a pharmaceutical drag. ##STR1## wherein X represents a group of the formula: ##STR2## (wherein R.sup.1 and R.sup.2, which may be the same or differnt, represent each a hydrogen atom, a lower alkyl group, a hydroxyalkyl group, or a lower alkenyl group); a group of the formula: ##STR3## (wherein A including the nitrogen atom shown represents a ring containing nitrogen and oxygen atoms); or a group of the formula: ##STR4## (wherein R.sup.3 represents a hydrogen atom or a lower alkyl group, and R.sup.4 represents a lower alkyl group); Y represents a group of the formula: ##STR5## or a group of the formula: ##STR6## (wherein R.sup.5 represents a hydrogen atom or a lower alkyl group), and n represents an integer of from 2 to 5.
摘要翻译： 用该配方鉴定出新的聚异戊二烯基化合物，并可用于药物阻力。 其中X表示下式的基团：其中R 1和R 2可以相同或不同，表示氢原子，低级烷基，羟基烷基或低级烯基） ; 下式的基团：其中A包括所示的氮原子代表含有氮和氧原子的环; 或下式的基团：其中R 3表示氢原子或低级烷基，R 4表示低级烷基。 Y表示下式的基团：
或下式的基团：其中R 5表示氢原子或低级烷基，n表示2〜5的整数。
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