摘要:
A liquid crystal light valve projection type image display apparatus comprises an electro-optic element and a Schlieren optical system. The electro-optic element has a liquid crystal layer having a dielectric and optical anisotropy. An electric field having a spatial intensity distribution according to an image signal is applied to said liquid crystal at a spatial period, so that a spatially phase-modulated phase diffraction grating is formed in the liquid crystal layer. Thus, a projected image in enlarged form is obtained. The fact that the electric field with a spatial period is applied to the liquid crystal leads to a constant light diffraction angle, and the modulation of the diffraction light intensity in the applied electric field enables an image corresponding to the input image signal to be projected at high light utilization.
摘要:
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要:
The present invention provides a compound having aggrecanase inhibitory activity and MMP-13 inhibitory activity, and useful as a therapeutic agent for osteoarthritis, rheumatoid arthritis and the like, more specifically, a cyclopropane compound of formula (1): wherein R1 is —(CH2)m—X—(CH2)n-A1 etc., wherein m and n are the same or different and each is 0 to 6, X is a single bond, etc. and A1 is a substituted C3-14 hydrocarbon ring group, etc.; R2 and R3 are the same or different and each is a hydrogen atom, —(CH2)p—X1—(CH2)q-A2, etc., wherein p and q are the same or different and each is 0 to 6, X1 is a single bond, etc. and A2 is an optionally substituted C3-14 hydrocarbon ring group, etc.; R4 is —CO2R9, etc., wherein R9 is a hydrogen atom, etc.; and R20 and R21 are the same or different and each is a hydrogen atom, —(CH2)m12—X12—(CH2)m12—R30, etc., wherein m12 and m12 are the same or different and each is 0 to 6, X12 is a single bond, etc. and R30 is a hydrogen atom, etc.; or a prodrug thereof or a pharmaceutically acceptable salt thereof.
摘要:
A withdrawn electrode is formed on a silicon substrate with intervention of upper and lower silicon oxide films each having circular openings corresponding to regions in which cathodes are to be formed. Tower-shaped cathodes are formed in the respective openings of the upper and lower silicon oxide films and of the withdrawn electrode. Each of the cathodes has a sharply tapered tip portion having a radius of 2 nm or less, which has been formed by crystal anisotropic etching and thermal oxidation process for silicon. The region of the silicon substrate exposed in the openings of the upper and lower silicon oxide films and the cathode have their surfaces coated with a thin surface coating film made of a material having a low work function.
摘要:
An optical pickup head for operating on an information recording medium includes a light source for emitting a light beam. A transparent base plate has opposite surfaces formed with a semitransparent film and a hologram respectively. The semitransparent film is exposed to the light beam emitted from the light source, and reflects a portion of the light beam emitted from the light source. The portion of the light beam which is reflected by the semitransparent film forms a forward light beam. A condenser optical system serves to focus the forward light beam on the information recording medium. The forward light beam is reflected at the information recording medium, and forms a backward light beam. The backward light beam successively passes through the condenser optical system, the semitransparent film, and the transparent base plate, and then reaches the hologram. The hologram generates a backward +1-order diffraction light beam from the backward light beam. A plurality of photodetectors serve to receive the +1-order diffraction light beam and to convert the received +1-order diffraction light beam into corresponding electric signals respectively.
摘要:
A 3,4-dihydrobenzoxazine compound of the present invention is represented by the following formula [1] (wherein X is a nitrogen atom or CR3; R1 is a hydrogen atom or a halogen atom; R2 is a C1-6 alkoxy group which may be substituted with the same or different 1 to 5 substituents selected from a halogen atom and a hydroxyl group; and R3 is a halogen atom. However, R1 is a halogen atom when X is CR3). This compound is effective in treating diseases to which the vanilloid receptor subtype 1 (VR1) activity is involved, such as pain, etc.
摘要:
The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要:
Disclosed is a compact optical pick-up head apparatus suitable for mass-production, which comprises a light radiation source, an element composed of photodetector split into a plurality of regions and integrated on the same base, an objective lens for focusing a beam from the above source on an optical disk, a blazed hologram integrated to the support member of the lens, a means for driving the support member to which the objective lens and blazed hologram are integrated in response to an output as servo signal output from the photodetector which receives a diffracted beam produced in such a manner that a return beam reflected or diffracted by the optical disk is incident on the objective lens integrated with the above hologram. The optical pickup apparatus according to the present invention employs a region-split-type phase hologram in which a pair of Flesnel zone plate-like patterns, by which a plurality of diffraction wavefronts having a different focus and the same diffraction order are produced outside an optical-axis, are non-superimposedly formed. The above hologram can be blazed with a pinpoint accuracy by lithography using a few mask patterns synthesized by a computer, and further a more preferably blazing can be realized by the combination of the ion beam etching and the lithography. Accordingly, not only noise caused by an unnecessary diffracted beam component but also the offset of a servo signal can be restrained and the size of the objective lens can be reduced by the integration of the entire optical system, which greatly contributes to the superminiaturization of an optical head.
摘要:
The invention is a field-emission element that is fabricated by forming an elevated surface and a base surface on a conductive substrate or a semiconductor substrate by applying a photolithographic process and an etching process, and making these surfaces cross at a step with an acute angle between the two surfaces. The intersection of the elevated surface with the step form a cathode having a radius of curvature of less than 20 nm. A gate electrode formed on the base electrode but insulated therefrom is disposed at a distance less than 1 .mu.m from said cathode by controlling the distance by the thickness of an etching protection mask. The field-emission element enables electrons to be emitted from the cathode when a voltage less than 150V is applied between the cathode and the gate electrode.
摘要:
A hyperbolic navigation receiver locates ships, and the like, by phase-locking the output signal of the voltage-controlled oscillator or voltage-controlled phase shifter of respectively provided tracking loop filters corresponding to the incoming signals from a master and slave station. The voltage-controlled oscillator or voltage-controlled phase shifter is caused to produce an output signal which is a multiple frequency of the incoming signal. Phase discrimination of the output signals is undertaken without the use of a multiplier.