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    Asymmetric benzoxanthene dyes
    2.
    发明申请
    Asymmetric benzoxanthene dyes 有权
    不对称苯并氧杂蒽染料

    公开(公告)号：US20040225119A1

    公开(公告)日：2004-11-11

    申请号：US10656826

    申请日：2003-09-05

    Applicant: Applera Corporation

    Inventor： Scott C. Benson ,  Steven M. Menchen ,  Peter D. Theisen ,  Kevin M. Hennessey ,  Vergine C. Furniss ,  Joan D. Hauser

    IPC: C12Q001/68 ,  C07H021/04 ,  C07D311/78

    CPC classification number: C07H21/00 ,  C07C39/38 ,  C09B11/00 ,  C09B11/08 ,  C12Q1/6869

    Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure 1 wherein Y1 and Y2 are individually hydroxyl, amino, imminium or oxygen, R1-R8 are hydrogen, fluorine, chlorine, alkyl alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof and R9 is acetylene, alkane, alkene, cyano, substituted phenyl and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure 2 where substituents R3-R7 correspond to like-referenced substituents in the structure of described above, and Y2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

    Abstract translation: 公开了一类用作荧光染料的不对称单苯并氧蒽化合物，其结构是其中Y 1和Y 2分别是羟基，氨基，亚氨基或氧，R 1 -R 8是氢，氟，氯，烷基烯烃，炔烃，磺酸酯，氨基，酰胺基， 腈，烷氧基，连接基团及其组合，R 9为乙炔，烷烃，烯烃，氰基，取代的苯基及其组合。 本发明还包括可用于合成具有通式结构的不对称苯并氧杂蒽化合物的新型中间体化合物，其中取代基R 3〜R 7对应于上述结构中的相同取代基，Y 2为羟基或胺。 另一方面，本发明包括合成上述染料化合物和中间体的方法。 在另一方面，本发明包括用不对称苯并氧杂蒽染料化合物标记的试剂，包括脱氧核苷酸，双脱氧核苷酸，亚磷酰胺和多核苷酸。 在另一方面，本发明包括利用这种染料化合物的方法和包括双脱氧多核苷酸测序和片段分析方法的试剂。

    Asymmetric benzoxanthene dye labelling reagents
    3.
    发明申请
    Asymmetric benzoxanthene dye labelling reagents 有权
    不对称苯并氧杂蒽染料标记试剂

    公开(公告)号：US20020115067A1

    公开(公告)日：2002-08-22

    申请号：US09976842

    申请日：2001-10-11

    Applicant: The Perkin-Elmer Corporation

    Inventor： Scott C. Benson ,  Steven M. Menchen ,  Peter D. Theisen ,  Kevin M. Hennessey ,  Vergine C. Furniss ,  Joan D. Hauser

    IPC: C12Q001/70 ,  C12Q001/68 ,  C07H021/04 ,  C07D491/04 ,  C07D311/78

    CPC classification number: C07H21/00 ,  C07C39/38 ,  C09B11/00 ,  C09B11/08 ,  C12Q1/6869

    Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure 1 wherein Y1 and Y2 are individually hydroxyl amino, imminium, or oxygen, R1-r8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof and R9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure 2 where substituents R3-R7 correspond to like-referenced substituents in the structure of described above, and Y2 is hydroxyl or amine. In another aspect the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

    Abstract translation: 公开了一类用作荧光染料的不对称单苯并氧蒽化合物，其结构是其中Y 1和Y 2分别是羟基氨基，亚氨基或氧，R 1 -R 8是氢，氟，氯，烷基，烯烃，炔烃，磺酸酯，氨基，酰氨基 腈，烷氧基，连接基团及其组合，R 9为乙炔，烷烃，烯烃，氰基，取代的苯基及其组合。 本发明还包括可用于合成具有通式结构的不对称苯并氧杂蒽化合物的新型中间体化合物，其中取代基R 3〜R 7对应于上述结构中的相同取代基，Y 2为羟基或胺。 另一方面，本发明包括合成上述染料化合物和中间体的方法。 在另一方面，本发明包括用不对称苯并氧杂蒽染料化合物标记的试剂，包括脱氧核苷酸，双脱氧核苷酸，亚磷酰胺和多核苷酸。 在另一方面，本发明包括利用这种染料化合物的方法和包括双脱氧多核苷酸测序和片段分析方法的试剂。

    Colorant compositions
    5.
    发明申请
    Colorant compositions 有权
    着色剂组合物

    公开(公告)号：US20080108817A1

    公开(公告)日：2008-05-08

    申请号：US12006510

    申请日：2008-01-03

    Applicant: Eric Stephens ,  Pat Moore

    Inventor： Eric Stephens ,  Pat Moore

    IPC: C07D401/02

    CPC classification number: C09B11/12 ,  C07D405/14 ,  C08K5/0041 ,  C09B11/00 ,  C09B69/103 ,  C11D3/40

    Abstract: Colorant compositions are useful for a wide variety of product applications. For example, colorants are used in tinting of polymers, providing colors to aqueous solution(s), and affording color to solid or semi-solid products such as detergents. Disclosed herein are colorant compositions having a triphenylmethane (“TPM”) structure having improved stability to alkaline conditions. Thus, the colorant compositions resist decolorization, even at relatively high pH levels.

    Abstract translation: 着色剂组合物可用于各种产品应用。 例如，着色剂用于聚合物着色，为水溶液提供颜色，并为固体或半固体产品如洗涤剂提供颜色。 本文公开了具有对碱性条件具有改进的稳定性的三苯基甲烷（“TPM”）结构的着色剂组合物。 因此，即使在相对较高的pH值下，着色剂组合物抵抗脱色。

    Asymmetric benzoxanthene dyes
    10.
    发明授权
    Asymmetric benzoxanthene dyes 有权
    不对称苯并氧杂蒽染料

    公开(公告)号：US07179906B2

    公开(公告)日：2007-02-20

    申请号：US10656826

    申请日：2003-09-05

    Applicant: Scott C. Benson ,  Steven M. Menchen ,  Peter D. Theisen ,  Kevin M. Hennessey ,  Vergine C. Furniss ,  Joan D. Hauser

    Inventor： Scott C. Benson ,  Steven M. Menchen ,  Peter D. Theisen ,  Kevin M. Hennessey ,  Vergine C. Furniss ,  Joan D. Hauser

    IPC: C07H19/04 ,  C07D311/78 ,  C07D311/82

    CPC classification number: C07H21/00 ,  C07C39/38 ,  C09B11/00 ,  C09B11/08 ,  C12Q1/6869

    Abstract: A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure wherein Y1 and Y2 are individually hydroxyl, amino, imminium, or oxygen, R1–R8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structure where substituents R3–R7 correspond to like-referenced substituents in the structure of described above, and Y2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

    Abstract translation: 公开了一类用作荧光染料的不对称单苯并氧蒽化合物，其具有其中Y 1和Y 2 2各自为羟基，氨基，亚氨基或氧的结构， 烷基，烯烃，炔烃，磺酸盐，氨基，酰氨基，腈，烷氧基，连接基团及其组合，R 1，R 2，R 2， 9是乙炔，烷烃，烯烃，氰基，取代的苯基及其组合。 本发明还包括可用于合成具有通式结构的不对称苯并氧杂蒽化合物的新型中间体化合物，其中取代基R 3〜R 7在其结构中对应于相似的取代基 并且Y 2是羟基或胺。 另一方面，本发明包括合成上述染料化合物和中间体的方法。 在另一方面，本发明包括用不对称苯并氧杂蒽染料化合物标记的试剂，包括脱氧核苷酸，双脱氧核苷酸，亚磷酰胺和多核苷酸。 在另一方面，本发明包括利用这种染料化合物的方法和包括双脱氧多核苷酸测序和片段分析方法的试剂。

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