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    Microfluidic large scale integration
    2.
    发明授权
    Microfluidic large scale integration 有权
    微流控大规模集成

    公开(公告)号：US08220494B2

    公开(公告)日：2012-07-17

    申请号：US10915960

    申请日：2004-08-10

    申请人： Vincent Studer ,  Stephen R. Quake ,  W. French Anderson ,  Sebastian J. Maerkl

    发明人： Vincent Studer ,  Stephen R. Quake ,  W. French Anderson ,  Sebastian J. Maerkl

    IPC分类号： F15C1/06

    CPC分类号： F15C1/06 ,  G06F17/5018 ,  G06F2217/16 ,  Y10T137/2224

    摘要： Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.

    摘要翻译： 使用基本的物理参数，提出了使用多层软光刻制造微流体阀的设计和方法。 根据本发明的阀的实施例具有基本上恒定厚度的弹性体膜部分，允许膜在其整个宽度上经受类似的施加压力的阻力。 用向上或向下可偏转的膜制造的这种开关阀可以具有非常低的致动压力，并且可以用于实现积分功能，例如集成微流体芯片中的泵和混合器。 阀性能的特征在于在宽范围的设计参数下测量致动压力和流动阻力，并将其与有限元模拟和替代阀几何形状进行比较。