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公开(公告)号：US20080029169A1
公开(公告)日：2008-02-07
申请号：US11463241
申请日：2006-08-08
IPC分类号： F16K11/20
CPC分类号： C12Q1/28 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B81B2201/0214 , B81B2201/054 , B81B2201/07 , B81C1/00119 , F15C5/00 , F16K11/20 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0318 , Y10T137/0329 , Y10T137/2224 , Y10T137/85938 , Y10T137/87249
摘要： High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.
摘要翻译： 高密度微流控芯片包含具有数千个微机械阀门和数百个单独可寻址腔室的管道网络。 这些流体装置类似于使用大规模集成（LSI）制造的电子集成电路。 这些网络的一个组件是流体多路复用器，它是二进制阀模式的组合阵列，通过允许使用最少数量的输入的复杂流体操纵来指数地增加网络的处理能力。 这些集成的微流体网络可用于构建各种高度复杂的微流体装置，例如比较器阵列的微流体模拟装置和类似于电子随机存取存储器的微流体存储器存储装置。
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公开(公告)号：US08220494B2
公开(公告)日：2012-07-17
申请号：US10915960
申请日：2004-08-10
IPC分类号： F15C1/06
CPC分类号： F15C1/06 , G06F17/5018 , G06F2217/16 , Y10T137/2224
摘要： Using basic physical arguments, a design and method for the fabrication of microfluidic valves using multilayer soft lithography is presented. Embodiments of valves in accordance with the present invention feature elastomer membrane portions of substantially constant thickness, allowing the membranes to experience similar resistance to an applied pressure across their entire width. Such on-off valves fabricated with upwardly- or downwardly-deflectable membranes can have extremely low actuation pressures, and can be used to implement active functions such as pumps and mixers in integrated microfluidic chips. Valve performance was characterized by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and comparing them to both finite element simulations and alternative valve geometries.
摘要翻译： 使用基本的物理参数，提出了使用多层软光刻制造微流体阀的设计和方法。 根据本发明的阀的实施例具有基本上恒定厚度的弹性体膜部分，允许膜在其整个宽度上经受类似的施加压力的阻力。 用向上或向下可偏转的膜制造的这种开关阀可以具有非常低的致动压力，并且可以用于实现积分功能，例如集成微流体芯片中的泵和混合器。 阀性能的特征在于在宽范围的设计参数下测量致动压力和流动阻力，并将其与有限元模拟和替代阀几何形状进行比较。
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公开(公告)号：US07143785B2
公开(公告)日：2006-12-05
申请号：US10670997
申请日：2003-09-24
CPC分类号： C12Q1/28 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B81B2201/0214 , B81B2201/054 , B81B2201/07 , B81C1/00119 , F15C5/00 , F16K11/20 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0318 , Y10T137/0329 , Y10T137/2224 , Y10T137/85938 , Y10T137/87249
摘要： High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.
摘要翻译： 高密度微流控芯片包含具有数千个微机械阀门和数百个单独可寻址腔室的管道网络。 这些流体装置类似于使用大规模集成（LSI）制造的电子集成电路。 这些网络的一个组件是流体多路复用器，它是二进制阀模式的组合阵列，通过允许使用最少数量的输入的复杂流体操纵来指数地增加网络的处理能力。 这些集成的微流体网络可用于构建各种高度复杂的微流体装置，例如比较器阵列的微流体模拟装置和类似于电子随机存取存储器的微流体存储器存储装置。
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公开(公告)号：US08039269B2
公开(公告)日：2011-10-18
申请号：US11698757
申请日：2007-01-26
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , B01J2219/0043 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N33/5302 , G01N33/54393
摘要： The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.
摘要翻译： 本发明提供用于表面构图微流体装置的基底的装置和方法，以及通过在基本排出溶剂和未结合的溶质分子的同时机械捕获分子复合物来检测和分析分子之间的相互作用。 分子复合物的实例包括蛋白质 - 蛋白质复合物和蛋白质 - 核酸复合物。
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公开(公告)号：US09329179B2
公开(公告)日：2016-05-03
申请号：US13317063
申请日：2011-10-06
IPC分类号： G01N33/563 , G01N33/543 , G01N33/53 , B01L3/00
CPC分类号： G01N33/543 , B01J2219/0043 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N33/5302 , G01N33/54393
摘要： The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.
摘要翻译： 本发明提供用于表面构图微流体装置的基底的装置和方法，以及通过在基本排出溶剂和未结合的溶质分子的同时机械捕获分子复合物来检测和分析分子之间的相互作用。 分子复合物的实例包括蛋白质 - 蛋白质复合物和蛋白质 - 核酸复合物。
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公开(公告)号：US20120129719A1
公开(公告)日：2012-05-24
申请号：US13317063
申请日：2011-10-06
CPC分类号： G01N33/543 , B01J2219/0043 , B01L3/5027 , B01L3/502707 , B01L3/502738 , B01L2300/0816 , B01L2300/0819 , B01L2300/0861 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N33/5302 , G01N33/54393
摘要： The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping a molecular complex while substantially expelling solvent and unbound solute molecules. Examples of molecular complexes include protein-protein complexes and protein-nucleic acid complexes.
摘要翻译： 本发明提供用于表面构图微流体装置的基底的装置和方法，以及通过在基本排出溶剂和未结合的溶质分子的同时机械捕获分子复合物来检测和分析分子之间的相互作用。 分子复合物的实例包括蛋白质 - 蛋白质复合物和蛋白质 - 核酸复合物。
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公开(公告)号：US20100154890A1
公开(公告)日：2010-06-24
申请号：US12577689
申请日：2009-10-12
CPC分类号： C12Q1/28 , B01L3/5025 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B81B2201/0214 , B81B2201/054 , B81B2201/07 , B81C1/00119 , F15C5/00 , F16K11/20 , F16K99/0001 , F16K99/0015 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/0318 , Y10T137/0329 , Y10T137/2224 , Y10T137/85938 , Y10T137/87249
摘要： High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large scale integration (LSI). A component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. These integrated microfluidic networks can be used to construct a variety of highly complex microfluidic devices, for example the microfluidic analog of a comparator array, and a microfluidic memory storage device resembling electronic random access memories.
摘要翻译： 高密度微流控芯片包含具有数千个微机械阀门和数百个单独可寻址腔室的管道网络。 这些流体装置类似于使用大规模集成（LSI）制造的电子集成电路。 这些网络的一个组件是流体多路复用器，它是二进制阀模式的组合阵列，通过允许使用最少数量的输入的复杂流体操纵来指数地增加网络的处理能力。 这些集成的微流体网络可用于构建各种高度复杂的微流体装置，例如比较器阵列的微流体模拟装置和类似于电子随机存取存储器的微流体存储器存储装置。
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