公开(公告)号：US11008286B2

公开(公告)日：2021-05-18

申请号：US16330474

申请日：2017-09-01

Applicant: Institute of Radiation Medicine Chinese Academy of Medical Sciences

Inventor： Hongqi Tian ,  Ying Cheng ,  Qianru Zhang ,  Zhimei Zhu ,  Yueying Wang

IPC: C07C323/44 ,  C07C321/04 ,  C07C319/12 ,  C07C319/06 ,  C07C323/25 ,  A61P39/02 ,  A61P35/00 ,  A61K31/16

Abstract: The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A1, A2, R1, R2, R5, R6, and R3 and R4 are defined herein. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

公开(公告)号：US20200237671A1

公开(公告)日：2020-07-30

申请号：US16790407

申请日：2020-02-13

Applicant: Translate Bio, Inc.

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K9/19 ,  C07D233/64 ,  A61K9/127 ,  C07C323/25 ,  C07C323/44 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  A61K31/7088 ,  C07C323/27 ,  C07J41/00 ,  C07J43/00

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent iransfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US20190202779A1

公开(公告)日：2019-07-04

申请号：US16330474

申请日：2017-09-01

Applicant: Institute of Radiation Medicine Chinese Academy of Medical Sciences

Inventor： Hongqi TIAN ,  Ying CHENG ,  Qianru ZHANG ,  Zhimei ZHU ,  Yueying WANG

IPC: C07C323/44 ,  C07C323/25 ,  A61P39/02

CPC classification number: C07C323/44 ,  A61K31/16 ,  A61P35/00 ,  A61P39/02 ,  C07C319/06 ,  C07C319/12 ,  C07C321/04 ,  C07C323/25

Abstract: The present invention discloses an amino mercaptan compound, preparation method thereof and use thereof in radiation protection. The compound has the structure of formula I, wherein A1 is selected from: —C(O)NR8—, —S(O)2—NR8—, —S(O)NR8—, and —R7—NR8—; A2 is selected from: carbonyl, sulfonyl, sulfinyl, substituted or unsubstituted C1-6 alkyl; R1, R2, R5, and R6 may be the same or different and are selected from: hydrogen, substituted or unsubstituted C1-C5 alkyl or heteroalkyl; n is an integer from 0 to 20,000; R3 and R4 are independently selected from: hydrogen, X, substituted or unsubstituted C1-6 alkyl; X is selected from: F, Cl, Br and I; R7 is selected from: substituted or unsubstituted C1-C6 alkyl; and R8 is selected from: hydrogen, substituted or unsubstituted C1-C6 alkyl. The compound has the effects of reducing the biological damage caused by ionizing radiation, extending the survival period and survival rate of the radiated animals, and significantly alleviating the side effects of radiotherapy, and has a low toxicity. The present invention opens up a new way for protection and treatment of ionizing radiation damage.

公开(公告)号：US20190055272A1

公开(公告)日：2019-02-21

申请号：US16078585

申请日：2017-02-22

Applicant: CONCENTRIC ANALGESICS, INC.

Inventor： Craig HUSFELD ,  Andrei W. KONRADI

IPC: C07F9/09 ,  C07D207/09 ,  C07F9/12 ,  C07F9/24 ,  C07F9/59 ,  C07D207/16 ,  C07D233/64 ,  C07C233/20 ,  C07C233/27 ,  C07C233/51 ,  C07C259/06 ,  C07C271/48 ,  C07C271/54 ,  C07C275/42 ,  C07C279/14 ,  C07C305/10 ,  C07C307/02 ,  C07C323/44 ,  C07C307/10 ,  C07C323/60 ,  C07C323/12 ,  A61P29/00

Abstract: Described herein are compounds, pharmaceutical compositions and medicaments that include such compounds, and methods of using such compounds to modulate transient receptor potential vanilloid 1 receptor (TRPV1) activity.

公开(公告)号：US09974772B2

公开(公告)日：2018-05-22

申请号：US15408643

申请日：2017-01-18

Applicant: Allergan, Inc.

Inventor： Richard L. Beard ,  Tien T. Duong ,  John E. Donello ,  Veena Viswanath ,  Michael E. Garst

IPC: A61K31/417 ,  A61K31/198 ,  A61K31/17 ,  A61K31/4045 ,  A61K31/216 ,  A61K31/197 ,  C07C323/60 ,  C07C317/50 ,  C07C323/44 ,  C07C317/42 ,  C07D233/64 ,  C07C275/30 ,  C07D209/20 ,  C07K5/062 ,  C07K5/078 ,  C07K5/072

CPC classification number: A61K31/417 ,  A61K31/17 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/4045 ,  C07C275/30 ,  C07C317/42 ,  C07C317/50 ,  C07C323/44 ,  C07C323/60 ,  C07D209/20 ,  C07D233/64 ,  C07K5/06017 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06113 ,  C07K5/06147 ,  C07K5/06156 ,  Y02A50/401

Abstract: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

公开(公告)号：US09717690B2

公开(公告)日：2017-08-01

申请号：US14124615

申请日：2012-06-08

Applicant: Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

Inventor： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC: A61K38/00 ,  A61K9/00 ,  A61K9/14 ,  C07C323/25 ,  C07C323/44 ,  C07D233/60 ,  A61K9/19 ,  C07D233/64 ,  A61K9/127 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  A61K31/7088 ,  C07C323/27 ,  C07J41/00 ,  C07J43/00 ,  A61K9/51

CPC classification number: A61K9/19 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/45 ,  A61K38/465 ,  A61K38/47 ,  A61K38/50 ,  C07C323/25 ,  C07C323/27 ,  C07C323/44 ,  C07D233/64 ,  C07J41/0055 ,  C07J43/003 ,  C12N15/88 ,  C12Y201/03003 ,  C12Y203/01 ,  C12Y207/08015 ,  C12Y301/06 ,  C12Y302/01022 ,  C12Y302/01035 ,  C12Y302/01046 ,  C12Y302/01076 ,  C12Y305/03001

Abstract: Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g., as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US09127027B2

公开(公告)日：2015-09-08

申请号：US14009658

申请日：2012-04-04

Applicant: John David Imig ,  William B. Campbell ,  John Russell Falck

Inventor： John David Imig ,  William B. Campbell ,  John Russell Falck

IPC: A61K31/66 ,  C07F9/40 ,  C07C233/46 ,  C07C233/56 ,  C07C275/20 ,  C07C309/15 ,  C07C311/18 ,  C07C311/51 ,  C07C317/28 ,  C07C323/44 ,  C07D249/12 ,  C07D257/04 ,  C07D271/06 ,  C07D277/34 ,  C07D277/82 ,  C07D291/04 ,  C07C233/47 ,  C07C237/22 ,  C07C311/19 ,  C07D271/07 ,  C07D277/593 ,  C07D285/08

CPC classification number: C07F9/40 ,  C07C233/46 ,  C07C233/47 ,  C07C233/56 ,  C07C237/22 ,  C07C275/20 ,  C07C309/15 ,  C07C311/18 ,  C07C311/19 ,  C07C311/51 ,  C07C317/28 ,  C07C323/44 ,  C07D249/12 ,  C07D257/04 ,  C07D271/06 ,  C07D271/07 ,  C07D277/34 ,  C07D277/593 ,  C07D277/82 ,  C07D285/08 ,  C07D291/04

Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.

Abstract translation: 作为EET激动剂的环氧二十碳三烯酸（EET）类似物的化合物和组合物，可用作治疗药物诱导的肾毒性，高血压和其它相关病症的药物。 进一步描述制备和使用化合物和组合物的方法。

公开(公告)号：US08993780B2

公开(公告)日：2015-03-31

申请号：US14102145

申请日：2013-12-10

Applicant: Allergan, Inc.

Inventor： Richard L. Beard ,  Tien T. Duong ,  John E. Donello ,  Veena Viswanath ,  Michael E. Garst

IPC: C07C275/30 ,  C07C317/50 ,  C07C323/44 ,  C07D233/64 ,  C07C317/42 ,  C07D209/20 ,  C07K5/062 ,  C07K5/078 ,  C07K5/072 ,  C07C323/60

CPC classification number: A61K31/417 ,  A61K31/17 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/4045 ,  C07C275/30 ,  C07C317/42 ,  C07C317/50 ,  C07C323/44 ,  C07C323/60 ,  C07D209/20 ,  C07D233/64 ,  C07K5/06017 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06113 ,  C07K5/06147 ,  C07K5/06156 ,  Y02A50/401

Abstract: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

Abstract translation: 本发明涉及N-脲取代氨基酸的新型酰胺衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。

公开(公告)号：US08841484B2

公开(公告)日：2014-09-23

申请号：US13236786

申请日：2011-09-20

Applicant: Keith W. Hutchenson ,  Anilkumar Raghavanpillai ,  Stefan Reinartz

Inventor： Keith W. Hutchenson ,  Anilkumar Raghavanpillai ,  Stefan Reinartz

IPC: C07C275/28 ,  C07C275/08 ,  C07C323/44 ,  B32B5/02 ,  C09D5/16 ,  C09K3/18 ,  C07C233/13 ,  C07C275/16 ,  C07C323/41

CPC classification number: C09K3/18 ,  C07C233/13 ,  C07C275/08 ,  C07C275/16 ,  C07C275/28 ,  C07C323/41 ,  C07C323/44 ,  C09D5/1662 ,  Y10T428/249981 ,  Y10T428/249986 ,  Y10T428/31989 ,  Y10T442/277 ,  Y10T442/2861 ,  Y10T442/2893 ,  Y10T442/291 ,  Y10T442/2992

Abstract: Disclosed are certain partially fluorinated amide compounds and composite materials containing the compounds. Also disclosed are methods for making the composite materials.

Abstract translation: 公开了某些部分氟化的酰胺化合物和含有该化合物的复合材料。 还公开了制备复合材料的方法。

公开(公告)号：US20130109866A1

公开(公告)日：2013-05-02

申请号：US13658523

申请日：2012-10-23

Applicant: ALLERGAN, INC.

Inventor： Richard L. Beard ,  Tien T. Duong ,  John E. Donello ,  Veena Viswanath ,  Michael E. Garst

IPC: C07C275/30 ,  C07D209/20 ,  C07D233/64 ,  C07C323/44 ,  C07C317/42

CPC classification number: A61K31/417 ,  A61K31/17 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K31/4045 ,  C07C275/30 ,  C07C317/42 ,  C07C317/50 ,  C07C323/44 ,  C07C323/60 ,  C07D209/20 ,  C07D233/64 ,  C07K5/06017 ,  C07K5/06034 ,  C07K5/06052 ,  C07K5/0606 ,  C07K5/06113 ,  C07K5/06147 ,  C07K5/06156 ,  Y02A50/401

Abstract: The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.