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公开(公告)号：US20230117671A1
公开(公告)日：2023-04-20
申请号：US17962965
申请日：2022-10-10
IPC分类号： C12M1/00 , B01D5/00 , C12M1/06 , C12M1/12 , F28F21/06 , B01F23/233 , B01F23/231 , B01F27/88 , B01F27/90 , B01F27/91 , B01F27/2121 , B01F35/51 , B01F35/92 , B01F35/10 , B01F35/513 , B01D47/05 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , C12M1/02 , F28B1/02 , F28F3/12
摘要： A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.
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公开(公告)号：US20230080444A1
公开(公告)日：2023-03-16
申请号：US17946862
申请日：2022-09-16
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US11591558B2
公开(公告)日：2023-02-28
申请号：US16628329
申请日：2018-06-19
发明人： Laurent Boitard
摘要： The method for analysis and cell culture comprises the following steps: generating a train (14) of ordered drops (16) in a carrier fluid (40), the train (14) of drops (16) comprising at least one culture drop (42), the culture drop (42) comprising a culture medium (50) and at least one cell (4), circulating the train (14) of drops (16) in a tube (10), incubating the train (14) of drops (16) in the tube (10), measuring at least one parameter indicative of the content of the culture drop (42) in the tube (10) at different times, recovering the culture drop (42) at one end (36) of the tube (10), the steps being carried out in a controlled atmosphere (6).
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公开(公告)号：US11584908B2
公开(公告)日：2023-02-21
申请号：US16137478
申请日：2018-09-20
发明人： Kenneth T. Kotz , Bryan D. Teece , James Gillett Truslow , Nathan Francis Moore , Jeffrey T. Borenstein , Vishal Tandon
IPC分类号： C12M1/02 , C12M1/12 , C12N15/87 , C12M1/00 , C12N15/86 , C12M3/06 , C12M1/40 , C12M1/34 , A61K48/00
摘要： A device for treatment of cells with particles is disclosed. The device includes a semi-permeable membrane positioned between two plates, the first plate defining a first flow chamber and comprising a port, a flow channel, a transverse port, and a transverse flow channel, the first flow chamber constructed and arranged to deliver fluid in a transverse direction along the first side of the semi-permeable membrane, the second plate defining a second flow chamber and comprising a port. A method for transducing cells is disclosed. The method includes introducing a fluid with cells and viral particles into a flow chamber adjacent a semi-permeable membrane such that the cells and the viral particles are substantially evenly distributed on the semi-permeable membrane. The method also includes introducing a recovery fluid to suspend the cells and the viral particles, and separating the cells from the viral particles. A method of activating cells is disclosed.
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公开(公告)号：US11566215B2
公开(公告)日：2023-01-31
申请号：US16863220
申请日：2020-04-30
申请人： 3D Biotek, LLC
发明人： Zongsen Wang , Wing Lau , Faribourz Payvandi , Peng Yue , Azadeh Jadali , Peter Materna
摘要： A bioreactor for culturing of cells is described. Screens suitable as a cell growth scaffold may comprise crossed fibers. Screens may be contained loosely in a screen holder, which in turn may be contained inside a manifold assembly. A lower manifold, screen holder and upper manifold may have identical or similar interior open cross-sections. Flow of liquid medium can occur upwardly through the array of screens, then flowing over a weir in the presence of an air pocket, and into a moat and a pump. The screen holder may have slots whose exterior-facing ligaments are rounded, and may have grooves whose interior-facing edges are rounded. These components may be located inside an incubator suitable to maintain desired environmental conditions and cleanliness.
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公开(公告)号：US20220389362A1
公开(公告)日：2022-12-08
申请号：US17754995
申请日：2020-10-12
发明人： Hee Sung PARK , In Yong SEO , Seoung Hoon LEE , Seon Ho JANG , Su Yeon LEE , Ji Young KIM , Hyo Jung LEE
摘要： A cell culture apparatus is provided. A cell culture apparatus according to one exemplary embodiment of the present invention comprises: a cell culture part comprising an accommodation space in which a plurality of supports for cell culture are disposed; a medium supply part for storing a predetermined amount of medium to be supplied to the cell culture part, and maintaining a predetermined carbon dioxide concentration of the medium stored therein by using carbon dioxide introduced from the outside through a gas supply port; and a pump, which interconnects the cell culture part and the medium supply part so as to circulate, in the cell culture part, a medium stored in the medium supply part.
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公开(公告)号：US11518974B2
公开(公告)日：2022-12-06
申请号：US15756031
申请日：2016-08-31
申请人： I PEACE, INC. , Koji Tanabe
发明人： Koji Tanabe , Brendan Kelly , Kenta Suto , Hidenori Shimoda , Ryoji Hiraide
IPC分类号： C12N5/074 , C12M1/36 , C12M1/00 , C12M1/34 , C12M1/33 , C12M1/42 , C12N5/078 , C12M3/00 , C12M1/02 , C12M1/12
摘要： A stem cell production system provided with a preintroduction cell-feeding solution channel 20 through which a solution containing cells passes, an induction factor-feeding solution mechanism 21 for feeding a pluripotency induction factor to the preintroduction cell-feeding solution channel 20, a factor introduction device 30 connected to the preintroduction cell-feeding solution channel 20 for making cells with induction factor introduced by introducing the pluripotency induction factor into the cells, a cell mass-making device 40 for making multiple cell masses comprising stem cells by culturing the cells with induction factor introduced, and a packaging device 100 for sequentially packaging each of the multiple cell masses.
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公开(公告)号：US11505771B2
公开(公告)日：2022-11-22
申请号：US16840562
申请日：2020-04-06
申请人： ForeLight, Inc
发明人： Adam Flynn , Jeff Kantarek
摘要： The present disclosure provides methods and materials for the cultivation and/or propagation of a photosynthetic organism. Such methods may comprise the use of a lamp assembly that comprises a plurality of circuit boards, each comprising at least three edges, arranged in a substantially spherical shape defining an interior lamp assembly volume, wherein the plurality of circuit boards comprise a first planar surface in contact with the interior lamp assembly volume and an opposing second planar surface comprising light emitting diodes (LEDs); and a barrier that surrounds the plurality of circuit boards forming the substantially spherical shape.
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公开(公告)号：US11492584B2
公开(公告)日：2022-11-08
申请号：US16537389
申请日：2019-08-09
发明人： Russell A. Newstrom , Andrew W. McFarland , Darcy K. Kelly-Greene , J. Tanner Nevill , Gang F. Wang
摘要： Incubators including an enclosure with an internal chamber configured to support a cell culture plate comprising a plurality of wells are disclosed. The enclosure includes a plurality of openings configured to allow access to the wells. The incubators include a sealing element configured to seal the plurality of openings in the enclosure. The sealing element comprises a plurality of openings corresponding to at least a subset of the plurality of openings in the enclosure. Access to the internal chamber can be provided by aligning the plurality of openings in the sealing element with the plurality of openings in the enclosure. Methods for using the incubators are also provided.
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公开(公告)号：US11452976B2
公开(公告)日：2022-09-27
申请号：US16474376
申请日：2017-12-22
摘要： The present invention relates to a mixing system for a bioreactor, comprising a plurality of supply units (10), each being able to hold media for use in a bioreactor a mixing unit (30) for creating a uniform mixing of media a first feeding mechanism (20), arranged to feed media from the supply units (10) into the mixing unit (30), a control unit (40) operatively connected to the first feeding mechanism (20) and the mixing unit (30), said control unit (40) being configured to control the first feeding mechanism (20) to feed predetermined amounts of media from the plurality of supply units (10) to the mixing unit (30), and further being configured to control the mixing unit (30) to create a uniform mixing of media. The invention also relates to a method for mixing media for use in a bioreactor.
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