公开(公告)号：US20060202325A1

公开(公告)日：2006-09-14

申请号：US10906809

申请日：2005-03-08

Applicant: Patrick Coico ,  David Edwards ,  Benjamin Fasano ,  Lewis Goldmann ,  Ellyn Ingalls ,  Michael June ,  Hilton Toy ,  Paul Zucco

Inventor： Patrick Coico ,  David Edwards ,  Benjamin Fasano ,  Lewis Goldmann ,  Ellyn Ingalls ,  Michael June ,  Hilton Toy ,  Paul Zucco

IPC: H01L23/34

CPC classification number: H01L23/4006 ,  H01L2023/405 ,  H01L2023/4062 ,  H01L2023/4081 ,  H01L2224/16 ,  H01L2224/73253 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2224/0401

Abstract: An integrated circuit chip mounting structure includes a chip carrier electrically connected to a circuit board with an integrated circuit chip mounted on the chip carrier. In addition, a thermally conductive device is thermally connected to the chip and a set of compressible support members are provided to transmit a portion of an applied compressive load from the thermally conductive device to the chip and chip carrier.

Abstract translation: 集成电路芯片安装结构包括芯片载体，其电连接到具有安装在芯片载体上的集成电路芯片的电路板。 此外，导热装置热连接到芯片，并且提供一组可压缩支撑构件以将施加的压缩载荷的一部分从导热装置传递到芯片和芯片载体。

公开(公告)号：US20060165608A1

公开(公告)日：2006-07-27

申请号：US11385267

申请日：2006-03-21

Applicant: Mark Dewis ,  David Edwards ,  Lesley Kendrick ,  Maria Wright ,  Amir Yusuf

Inventor： Mark Dewis ,  David Edwards ,  Lesley Kendrick ,  Maria Wright ,  Amir Yusuf

IPC: A61K9/68 ,  A23G3/00

CPC classification number: A23G3/36 ,  A23G3/48 ,  A23G4/06 ,  A23G4/068 ,  A23L27/2022 ,  A23L27/29 ,  C11B9/0011

Abstract: This invention pertains to a method for flavoring an ingestible composition with a flavoring agent in organoleptically purified form, unaccompanied by substances of natural origin present in mango. The flavoring agent may be used in a wide variety of ingestible vehicles such as chewing gum compositions, hard and soft confections, dairy products, beverage products including juice drinks and juice products, green vegetable and chicken products, and the like. The present invention also pertains to an ingestible composition comprising an ingestible vehicle and an organoleptically effective amount of the purified flavoring agent. The present invention further pertains to ethyl 3-mercaptobutyrate represented by the formula, CH3(SH)CHCH2COOCH2CH3, in purified form, unaccompanied by substances of natural origin present in mango. The present invention still further pertains to a method to confer, enhance, improve, or modify the odor properties of a perfuming composition or a perfumed article, which comprises adding to the perfuming composition or perfumed article, ethyl 3-mercaptobutyrate represented by the formula, CH3(SH)CHCH2COOCH2CH3. The present invention still further pertains to a perfuming composition or a perfumed article containing as an active perfuming ingredient, ethyl 3-mercaptobutyrate represented by the formula, CH3(SH)CHCH2COOCH2CH3. The present invention also pertains to a method for preparing ethyl 3-mercaptobutyrate which comprises reacting ethyl crotonate with sodium hydrogen sulfide and sodium bicarbonate to form the disulfide dimer of ethyl 3-mercaptobutyrate followed by reducing the disulfide dimer to yield ethyl 3-mercaptobutyrate.

公开(公告)号：US20060118451A1

公开(公告)日：2006-06-08

申请号：US10530833

申请日：2003-10-13

Applicant: David Edwards ,  Bruce Drew ,  Michael Parkes ,  William MCCarthy

Inventor： David Edwards ,  Bruce Drew ,  Michael Parkes ,  William MCCarthy

IPC: B65D75/00

CPC classification number: B65D81/02 ,  B65D65/46 ,  B65D75/305 ,  B65D75/327 ,  B65D75/34 ,  B65D75/42 ,  C11D17/042

Abstract: A product containerisation system created by attaching at least one product (X) to one side of a planar sheet (103) by overlaying a polymeric film (101) over the product and one side of the planar sheet by a skin packing process, and there folding the planar sheet into an erected container or package, in which the polymeric film is selected and arranged such that twisting the product (X) and overlying film about an axis (105) transverse to the planar sheet shears the polymeric film generally around the perimeter (107) of the product adjacent the planar sheet.

Abstract translation: 一种产品集装箱系统，其通过将聚合物膜（101）通过皮肤包装过程覆盖在产品和平面片的一侧上而将至少一个产品（X）附接到平面片材（103）的一侧，并且在那里 将平面片折叠成竖立的容器或包装，其中选择和布置聚合物膜，使得绕横向于平面片的轴线（105）扭转产品（X）和覆盖膜，大致围绕周边剪切聚合物膜 （107）邻近平板。

公开(公告)号：US20060104031A1

公开(公告)日：2006-05-18

申请号：US10904555

申请日：2004-11-16

Applicant: Evan Colgan ,  Frank Pompeo ,  Glenn Daves ,  Hilton Toy ,  Bruce Furman ,  David Edwards ,  Michael Gaynes ,  Mukta Farooq ,  Sung Kang ,  Steven Ostrander ,  Jaimal Williamson ,  Da-Yuan Shih ,  Donald Henderson

Inventor： Evan Colgan ,  Frank Pompeo ,  Glenn Daves ,  Hilton Toy ,  Bruce Furman ,  David Edwards ,  Michael Gaynes ,  Mukta Farooq ,  Sung Kang ,  Steven Ostrander ,  Jaimal Williamson ,  Da-Yuan Shih ,  Donald Henderson

IPC: H05K7/20

CPC classification number: H01L23/4735 ,  H01L2224/16 ,  H01L2224/32225 ,  H01L2224/73204 ,  H01L2924/00011 ,  H01L2924/00014 ,  H01L2924/15311 ,  H01L2224/0401

Abstract: A cooling system for an electronic component on a component carrier is provided. The system includes a frame, a spray manifold, and a sealing member. The frame has an opening and is connectable to the component carrier so that an annular area is defined between the opening and the electronic component. The spray manifold is sealed over the opening to define a spray area over a back surface of the electronic component. The spray manifold sprays a cooling fluid on the back surface. The sealing member seals the annular region so that input/output connectors on the component carrier are isolated from the cooling fluid.

Abstract translation: 提供了一种用于组件载体上的电子部件的冷却系统。 该系统包括框架，喷雾歧管和密封构件。 框架具有开口并且可连接到部件载体，使得在开口和电子部件之间限定环形区域。 喷雾歧管被密封在开口上以限定电子部件的后表面上方的喷射区域。 喷雾歧管在后表面喷洒冷却液。 密封构件密封环形区域，使得部件载体上的输入/输出连接器与冷却流体隔离。

公开(公告)号：US20060056156A1

公开(公告)日：2006-03-16

申请号：US10939230

申请日：2004-09-10

Applicant: David Long ,  Glenn Daves ,  David Edwards ,  Ronald Hering ,  Sushumna Iruvanti ,  Kenneth Marston ,  Jason Miller

Inventor： David Long ,  Glenn Daves ,  David Edwards ,  Ronald Hering ,  Sushumna Iruvanti ,  Kenneth Marston ,  Jason Miller

IPC: H05K7/20

CPC classification number: H01L23/4006 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A flexible plate for securing a microchip surface to the surface of a cooling device. The flexible plate allows for z-directional movement between the microchip subassembly having a circuit board and a semiconductor substrate, and the cooling device. The flexible plate is a compact, single piece design that provides constraints in alignment in the x-, y-, and theta-directions, while allowing for z-direction compliance and tilt compliance. The flexible plate has tabs for mounting the microchip subassembly and tabs for mounting the cooling device. The microchip tabs are opposite one another and the cooling device mounting tabs are opposite one another. The flexible plate is a one-piece construction made from sheet metal, plastic, or metal castings. The flexible plate has a band with all the tabs mounted on the inside of the band, or one set of tabs mounted on the outside of the band.

Abstract translation: 用于将微芯片表面固定到冷却装置的表面的柔性板。 柔性板允许具有电路板的微芯片组件和半导体衬底之间的z方向运动以及冷却装置。 柔性板是一种紧凑的单件设计，可在x轴，y轴和θ轴方向上对齐，同时允许z方向顺应性和倾斜顺应性。 柔性板具有用于安装用于安装冷却装置的微芯片组件和突出部的突片。 微芯片接头彼此相对，并且冷却装置安装接头彼此相对。 柔性板是由金属板，塑料或金属铸件制成的一体式结构。 柔性板具有带子，其中所有突片安装在带的内部，或者一组安装在带的外侧上的突片。

公开(公告)号：US20060018776A1

公开(公告)日：2006-01-26

申请号：US11166682

申请日：2005-10-11

Applicant: David Mioduszewski ,  David Edwards ,  Richard Jacobson

Inventor： David Mioduszewski ,  David Edwards ,  Richard Jacobson

IPC: F04B9/08 ,  F04B47/00

CPC classification number: F04B9/14 ,  F04B47/00

Abstract: A pneumatic groundwater retrieving piston pump comprising generally of a piston and a foot valve is disclosed. A pneumatic driver slides the piston assembly up and down inside the foot valve assembly, which is connected to the driver by means of a stationary length of pipe. The drive shaft of the pneumatic driver is connected to the piston assembly by means of a polypropylene coated epoxy resin based rod. On the upward stroke the foot valve opens and lets water enter the volume below the piston assembly and the piston assembly check valve is closed and lifts the column of water. On the down stroke the foot valve closes holding the column of water and the piston check valve open, and allows the water to pass through to recharge the cylinder for the next lift cycle.

Abstract translation: 公开了一种通常包括活塞和底阀的气动地下水回收活塞泵。 气动驱动器在底阀组件内上下滑动活塞组件，该阀组件通过固定长度的管连接到驱动器。 气动驱动器的驱动轴通过聚丙烯涂覆的环氧树脂基棒连接到活塞组件。 在向上行程中，脚阀打开，让水进入活塞组件下方的体积，活塞组件止回阀关闭并提升水柱。 在下降行程中，脚踏阀关闭，保持水柱，活塞止回阀打开，并允许水通过，为下一个提升循环的气缸充气。

公开(公告)号：US20060002996A1

公开(公告)日：2006-01-05

申请号：US11176841

申请日：2005-07-07

Applicant: David Edwards ,  Jeffrey Hrkach

Inventor： David Edwards ,  Jeffrey Hrkach

IPC: A61K38/28 ,  A61K9/127

CPC classification number: A61K9/0075 ,  A61K9/1617 ,  Y10S514/951 ,  Y10S514/97 ,  Y10S514/975

Abstract: Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

Abstract translation: 具有改善的蛋白质稳定性的喷雾干燥颗粒通过喷雾干燥包括蛋白质，磷脂和有机 - 水性共溶剂的混合物而产生。 包含至少1重量％磷脂的喷雾干燥颗粒，其振实密度小于0.4g / cm 3，可以制备。 颗粒可以输送到患者的肺部系统。

公开(公告)号：US20050265928A1

公开(公告)日：2005-12-01

申请号：US11125010

申请日：2005-05-09

Applicant: David Edwards ,  Jean Sung ,  Brian Pulliam ,  Eric Wehrenberg-Klee ,  Evan Schwartz ,  Philip Dreyfuss ,  Sandeep Kulkarni ,  Erez Lieberman

Inventor： David Edwards ,  Jean Sung ,  Brian Pulliam ,  Eric Wehrenberg-Klee ,  Evan Schwartz ,  Philip Dreyfuss ,  Sandeep Kulkarni ,  Erez Lieberman

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61K39/00 ,  A61K39/015 ,  A61L9/04

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K39/00 ,  A61K39/015 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/544 ,  A61K2039/55555 ,  Y02A50/412

Abstract: Particulate compositions for delivery, preferably pulmonary, which provide sustained release of antigens, preferably DNA and/or peptide and/or protein antigens, have been developed. In the preferred embodiment, aggregate nanoparticles are in the aerodynamic range of 1-5 microns diameter and fly deep into the lungs. As the aggregate particles degrade in the body, MSP-1 and AMA-1 proteins are released into the blood stimulating a humoural immune response. The individual particles in the range of 0.1 micron are preferentially phagocytosed by APCs which express the proteins encoded by AMA-1 and MSP-1 plasmid DNA thereby initiating the cellular immune response that is necessary for a complete immunity.

Abstract translation: 已经开发了用于递送，优选肺部的颗粒组合物，其提供抗原的持续释放，优选DNA和/或肽和/或蛋白质抗原。 在优选实施方案中，聚集体纳米颗粒处于1-5微米直径的空气动力学范围内并深入肺部。 随着聚集体颗粒在体内降解，MSP-1和AMA-1蛋白被释放到刺激幽门免疫应答的血液中。 0.1微米范围内的单个颗粒优先被表达由AMA-1和MSP-1质粒DNA编码的蛋白质的APC吞噬，由此引发完全免疫所必需的细胞免疫应答。

公开(公告)号：US20050255152A1

公开(公告)日：2005-11-17

申请号：US10511413

申请日：2003-04-17

Applicant: David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

Inventor： David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K38/09 ,  A61K38/22 ,  A61K47/48

CPC classification number: A61K31/704 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K47/62 ,  A61K47/6933 ,  B82Y5/00

Abstract: A method and compositions for targeted drug delivery have been developed. The compositions include a targeting molecules such as a hormone that specifically binds to a receptor on the surface of the targeted cells; a drug to be delivered, such as a toxin that will kill the targeted cells; and a nanoparticle, which contains on or within the nanoparticle, the drug to be delivered, as well as has attached thereto, the targeting molecule. Nanoparticles can consist of drug or drug associated with carrier, such as a controlled or sustained release materials like a poly(lactide-co-glycolide), a liposome or surfactant. The compositions are administered by injections in most cases, although compositions can be applied topically orally, nasally, vaginally, rectally, and ocularly. Compositions can also be administered to the pulmonary or respiratory system, most preferably in an aerosol.

Abstract translation: 已经开发了用于靶向药物递送的方法和组合物。 组合物包括靶向分子，例如与靶细胞表面上的受体特异性结合的激素; 待传递的药物，例如将杀死靶细胞的毒素; 以及在纳米颗粒上或内部含有待递送药物以及与其连接的靶向分子的纳米颗粒。 纳米颗粒可以由与载体相关的药物或药物组成，例如受控或持续的释放材料如聚（丙交酯 - 共 - 乙交酯），脂质体或表面活性剂。 组合物在大多数情况下通过注射施用，尽管组合物可以局部地口服，经鼻，阴道，直肠和眼睛施用。 组合物也可以施用于肺或呼吸系统，最优选以气溶胶施用。

公开(公告)号：US20050244614A1

公开(公告)日：2005-11-03

申请号：US11176435

申请日：2005-07-07

Applicant: Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

Inventor： Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

IPC: B29C35/08 ,  B29C41/46 ,  B29C59/02 ,  B29C59/04 ,  B29D7/01 ,  B29D11/00 ,  B32B3/00 ,  B32B3/28 ,  B32B3/30 ,  G02B5/30 ,  H05B6/00

CPC classification number: B32B3/30 ,  B29C35/0272 ,  B29C35/0805 ,  B29C35/0888 ,  B29C59/02 ,  B29C59/04 ,  B29C2035/0811 ,  B29C2035/0822 ,  B29C2035/0838 ,  B29C2035/0855 ,  B29C2035/0861 ,  B29C2059/023 ,  B29L2011/00 ,  B32B7/12 ,  B32B27/08 ,  B32B27/308 ,  B32B27/36 ,  B32B38/06 ,  B32B2307/412 ,  B32B2307/42 ,  B32B2307/516 ,  B32B2307/704 ,  B32B2307/706 ,  B32B2398/20 ,  G02B5/3083 ,  Y10T428/24479 ,  Y10T428/2457

Abstract: A method of making an embossed optical sheet material includes: providing an optically anisotropic, uniaxially oriented polymer substrate having a first major surface and a second major surface; heating a patterned tool using radiant energy from a radiant energy source, wherein the pattern comprises a plurality of parallel raised microstructures having a longitudinal direction; pressing the tool against the first major surface of the polymer substrate such that the longitudinal direction of the raised microstructures is substantially parallel to the direction of orientation of the polymer substrate, to soften the first major surface of the polymer substrate and emboss groove-shaped microchannels into the polymer substrate; cooling the embossed polymer substrate; and separating the tool from the polymer substrate; wherein the orientation of the polymer substrate is unchanged throughout the polymer substrate and first major surface.