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    Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid
    92.
    发明授权
    Microorganisms and methods for the biosynthesis of adipate, hexamethylenediamine and 6-aminocaproic acid 有权

    公开(公告)号：US11208673B2

    公开(公告)日：2021-12-28

    申请号：US16213671

    申请日：2018-12-07

    Applicant: Genomatica, Inc.

    Inventor： Mark J. Burk ,  Anthony P. Burgard ,  Robin E. Osterhout ,  Priti Pharkya

    IPC: C12P17/10 ,  C12N1/38 ,  C12N15/52 ,  C12P7/40 ,  C12P7/44 ,  C12P13/00 ,  C12P13/02 ,  C12P17/12

    Abstract: The invention provides a non-naturally occurring microbial organism having a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway. The invention additionally provides a method for producing 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid. The method can include culturing a 6-aminocaproic acid, caprolactam or hexametheylenediamine producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce 6-aminocaproic acid, caprolactam, hexametheylenediamine or levulinic acid.

    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USING SAME
    93.
    发明申请
    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USING SAME 有权

    公开(公告)号：US20210348134A1

    公开(公告)日：2021-11-11

    申请号：US17280181

    申请日：2019-09-25

    Applicant: GENOMATICA, INC.

    Inventor： Amit SHAH ,  Joseph WARNER

    IPC: C12N9/02 ,  C12P7/04 ,  C12P7/62 ,  C12P13/02 ,  C12N15/90

    Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

    1,3-fatty diol compounds and derivatives thereof
    94.
    发明授权
    1,3-fatty diol compounds and derivatives thereof 有权

    公开(公告)号：US11168046B2

    公开(公告)日：2021-11-09

    申请号：US16739645

    申请日：2020-01-10

    Applicant: Genomatica, Inc.

    Inventor： Haibo Wang

    IPC: C07C33/035 ,  C07H15/10

    Abstract: The disclosure relates to the field of specialty chemicals. In particular, the disclosure provides novel 1,3-fatty-diol compounds and derivatives thereof which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc.

    Multifunctional Fatty Acid Derivatives And Biosynthesis Thereof
    96.
    发明申请
    Multifunctional Fatty Acid Derivatives And Biosynthesis Thereof 有权

    公开(公告)号：US20210189439A1

    公开(公告)日：2021-06-24

    申请号：US17053190

    申请日：2019-05-03

    Applicant: Genomatica, Inc.

    Inventor： Andreas W. SCHIRMER ,  Risha Lindig BOND ,  Erin Frances PERRY

    IPC: C12P7/18 ,  C12N15/52

    Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides novel multifunctional fatty acid derivative molecules such as e.g., fatty triols, fatty tetrols, dihydroxy fatty acids, etc. The disclosure further provides derivatives of the disclosed multifunctional molecules which are useful e.g., in the production of personal care products, surfactants, detergents, polymers, paints, coatings, and as emulsifiers, emollients, and thickeners in cosmetics and foods, as industrial solvents and plasticizers, etc. The disclosure further provides biochemical pathways, recombinant microorganisms and methods for the biological production of various multifunctional fatty acid derivatives.

    Production Of Non-Native Monounsaturated Fatty Acids In Bacteria
    97.
    发明申请
    Production Of Non-Native Monounsaturated Fatty Acids In Bacteria 有权

    公开(公告)号：US20210189373A1

    公开(公告)日：2021-06-24

    申请号：US17271439

    申请日：2019-08-28

    Applicant: Genomatica, Inc.

    Inventor： Andreas W. SCHIRMER ,  Katherine Ann MURPHY ,  Erin Frances PERRY

    IPC: C12N9/88 ,  C12N9/16 ,  C12N9/10 ,  C12N9/02 ,  C12N9/04 ,  C12P7/64

    Abstract: The disclosure relates to the field of specialty chemicals and methods for their synthesis. In embodiments, the disclosure provides viable bacterial cells which comprise heterologous dual 3-hydroxy-acyl-ACP dehydratase/isomerases, etc. The disclosure further provides monounsaturated fatty acid derivative molecules produced by the viable bacterial cells which are non-native to the bacterial cells. The disclosure further provides methods for the preparation and production of non-native monounsaturated fatty acid derivative molecules such as e.g., an ω3-monounsaturated fatty acid derivative, an ω5-monounsaturated fatty acid derivative, an ω9-monounsaturated fatty acid derivative, an ω11-monounsaturated fatty acid fatty acid derivative, etc.

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