公开(公告)号：US08057459B2

公开(公告)日：2011-11-15

申请号：US12352393

申请日：2009-01-12

申请人： Robert Rioux ,  Paul DiCarlo

发明人： Robert Rioux ,  Paul DiCarlo

IPC分类号： A61M31/00

CPC分类号： A61M5/329 ,  A61M5/3291 ,  A61M25/003 ,  A61M25/007 ,  A61M25/0084 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0039 ,  A61M2025/0089

摘要： An agent delivery device includes an inner tubular body having a proximal end, a sharpened distal end, a delivery lumen extending therebetween, and one or more outlet ports on the distal end communicating with the delivery lumen. The device also includes one or more seals sealing the one or more outlet ports, the one or more seals capable of being melted to allow a fluid to be delivered from the delivery lumen through the one or more outlet ports. The agent delivery device may further include a monopolar or bipolar electrode and/or a radio-opaque marker carried at the distal end of the device. The inner tubular body can be made from a conductive material to thereby allow the inner tubular body to function as an electrode.

摘要翻译： 药剂递送装置包括内管状体，其具有近端，锐化的远端，在其间延伸的输送腔和与输送腔连通的远端上的一个或多个出口。 所述装置还包括密封所述一个或多个出口端口的一个或多个密封件，所述一个或多个密封件能够被熔化以允许流体通过所述一个或多个出口端口从所述输送腔室输送。 药剂递送装置还可以包括在装置的远端处携带的单极或双极电极和/或不透射线的标记。 内管状体可以由导电材料制成，从而允许内管体用作电极。

公开(公告)号：US08034035B2

公开(公告)日：2011-10-11

申请号：US10768565

申请日：2004-01-29

申请人： Karla Weaver ,  Paul DiCarlo

发明人： Karla Weaver ,  Paul DiCarlo

IPC分类号： A61M5/00

CPC分类号： A61M39/24 ,  A61M25/0097 ,  A61M25/0606 ,  A61M25/0637 ,  A61M39/22 ,  A61M2039/242 ,  A61M2039/2426

摘要： A pressure actuated valve for controlling the flow of fluid through a medical device, the valve comprises a housing including a lumen extending therethrough and a flow control membrane extending across the lumen to control the flow of fluid through the lumen. The membrane includes a plurality of slits extending therethrough so that, when the membrane is acted upon by a pressure of at least a threshold magnitude, the slits open to permit flow through the lumen and, when not acted upon by a pressure of at least the predetermined magnitude, the slits are maintained closed by a biasing force applied thereto by the membrane to prevent flow through the lumen. Each of the slits extends between end portions thereof along a curve wherein a distance between a first end portion of a first one of the slits and a first end portion of a second one of the slits is a minimum distance between the first and second slits.

摘要翻译： 一种用于控制通过医疗装置的流体流动的压力致动阀，所述阀包括壳体，所述壳体包括延伸穿过其中的内腔和延伸穿过所述内腔的流动控制膜，以控制通过所述内腔的流体流动。 膜包括延伸穿过其中的多个狭缝，使得当膜以至少阈值大小的压力作用时，狭缝开放以允许流过内腔，并且当不受至少 通过由膜施加到其上的偏压力来保持狭缝保持关闭，以防止流过管腔。 每个狭缝沿其曲线在其端部之间延伸，其中第一个狭缝中的第一个端部与第二个狭缝的第一端部之间的距离是第一和第二狭缝之间的最小距离。

公开(公告)号：US20110213358A1

公开(公告)日：2011-09-01

申请号：US13106563

申请日：2011-05-12

申请人： Janel Lanphere ,  Paul DiCarlo ,  Steven Anderson

发明人： Janel Lanphere ,  Paul DiCarlo ,  Steven Anderson

IPC分类号： A61B18/18

CPC分类号： A61B18/18 ,  A61B18/14 ,  A61B18/1815 ,  A61B90/04 ,  A61B2017/008 ,  A61B2090/0472 ,  A61B2090/0481 ,  A61B2090/049 ,  A61K9/0019 ,  A61K47/30 ,  A61L27/3683 ,  A61N7/02

摘要： Polymer insulators and methods of using polymer insulators are disclosed. In some embodiments, a method includes separating a first portion of a subject's tissue from a second portion of the subject's tissue so that there is a space between the first and second portions of tissue. Deionized water, a buffered saline solution, liquid polymers, gels, particles, foams, and/or gases are disposed between the first and second portions of tissue, and the first portion of tissue is exposed to energy to treat the first portion of tissue.

摘要翻译： 公开了聚合物绝缘体和使用聚合物绝缘体的方法。 在一些实施例中，一种方法包括将受试者组织的第一部分与受试者组织的第二部分分开，使得在组织的第一和第二部分之间存在空间。 去离子水，缓冲盐溶液，液体聚合物，凝胶，颗粒，泡沫和/或气体设置在组织的第一和第二部分之间，并且组织的第一部分暴露于能量以处理组织的第一部分。

公开(公告)号：US07962223B2

公开(公告)日：2011-06-14

申请号：US12271714

申请日：2008-11-14

申请人： Kimbolt Young ,  Steven Walak ,  Paul DiCarlo

发明人： Kimbolt Young ,  Steven Walak ,  Paul DiCarlo

IPC分类号： A61N1/06

CPC分类号： A61B18/1477 ,  A61B18/148 ,  A61B2018/00154 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475 ,  A61B2018/1495 ,  A61B2218/002

摘要： Tissue ablation probes and methods for treating tissue are provided. The tissue ablation probe comprises an elongated probe shaft, at least one electrode carried by the distal end of the probe shaft, and a pharmaceutical agent carried by the probe shaft. The pharmaceutical agent may be disposed on the electrode(s), the probe shaft, or a releasable portion associated with the electrode or the probe shaft. A method for treating tissue comprises introducing a tissue ablation probe to a tissue site, operating the tissue ablation probe to ablate tissue at the tissue site, and releasing a pharmaceutical agent from the tissue ablation probe at the tissue site.

摘要翻译： 提供组织消融探针和治疗组织的方法。 组织消融探针包括细长的探针轴，由探针轴的远端承载的至少一个电极和由探针轴承载的药剂。 药剂可以设置在与电极或探针轴相关联的电极，探针轴或可释放部分上。 一种用于治疗组织的方法包括将组织消融探针引入组织部位，操作组织消融探针以烧蚀组织部位处的组织，以及在组织部位从组织消融探针释放药剂。

公开(公告)号：US07901770B2

公开(公告)日：2011-03-08

申请号：US10791103

申请日：2004-03-02

申请人： Paul DiCarlo ,  Robert F. Rioux ,  James Tobin ,  Barbara Bell ,  Thomas V. Casey, II ,  William J. Shaw

发明人： Paul DiCarlo ,  Robert F. Rioux ,  James Tobin ,  Barbara Bell ,  Thomas V. Casey, II ,  William J. Shaw

IPC分类号： B32B5/66

CPC分类号： A61K49/0414 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

摘要： Embolic compositions and methods of delivering the compositions are disclosed. In some embodiments, the embolic compositions include a shape memory material.

摘要翻译： 公开了栓塞组合物和递送组合物的方法。 在一些实施方案中，栓塞组合物包括形状记忆材料。

公开(公告)号：US07887504B2

公开(公告)日：2011-02-15

申请号：US11220519

申请日：2005-09-08

申请人： Mark L. Adams ,  Oscar R. Carrillo, Jr. ,  Michael S. H. Chu ,  Paul DiCarlo ,  Kristian DiMatteo ,  Robert F. Rioux ,  William J. Shaw ,  Vincent A. Turturro

发明人： Mark L. Adams ,  Oscar R. Carrillo, Jr. ,  Michael S. H. Chu ,  Paul DiCarlo ,  Kristian DiMatteo ,  Robert F. Rioux ,  William J. Shaw ,  Vincent A. Turturro

IPC分类号： A61B10/00 ,  A61M3/00

CPC分类号： A61M1/0084 ,  A61M3/0283 ,  A61M2210/1064

摘要： An apparatus includes an elongate body including a proximal end portion and a distal end portion and configured to be at least partially inserted into a body cavity. The elongate body defines a first passageway and a second passageway. The first passageway is configured to communicate fluid from the distal end portion in a first direction, and the second passageway is configured to communicate material from outside of the elongate body into the distal end portion in a second direction opposite the first direction and includes at least one port. An actuator is coupled to the elongate body and is configured to guide the distal end of the elongate body to an area of interest identifiable by a virtual colonoscopy.

摘要翻译： 一种装置包括细长主体，其包括近端部分和远端部分，并且构造成至少部分地插入到体腔中。 细长主体限定第一通道和第二通道。 第一通道构造成在第一方向上从远端部分传送流体，并且第二通道构造成在与第一方向相反的第二方向上将材料从细长主体的外部连通到远端部分，并且至少包括 一个港口 致动器联接到细长主体并且构造成将细长体的远端引导到通过虚拟结肠镜检查可识别的感兴趣区域。

公开(公告)号：US20100256631A1

公开(公告)日：2010-10-07

申请号：US12817035

申请日：2010-06-16

申请人： Robert F. Rioux ,  Paul DiCarlo ,  Arnold Oyola

发明人： Robert F. Rioux ,  Paul DiCarlo ,  Arnold Oyola

IPC分类号： A61B18/14

CPC分类号： A61B18/1402 ,  A61B2018/00065 ,  A61B2018/00404 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00607 ,  A61B2018/1472

摘要： Assemblies and methods are provided for resecting a portion of tissue to be removed (e.g., unhealthy tissue, such as cancerous tissue) from a portion of the tissue to be retained (e.g., healthy tissue) within a patient is provided. An electrically conductive fluid, such as saline, may be absorbed into a hydrophilic electrode. Electrical energy (e.g., radio frequency (RF) energy) is conveyed to or from the hydrophilic electrode while being moved in proximity to the tissue along a resection line, whereby tissue adjacent to the resection line is coagulated. A resection member, such as a blunt resection member or a resection electrode, which may be on the same device as the hydrophilic electrode, is used to separate the tissue along the resection line to resect the tissue portion to be removed from the tissue portion to be retained.

摘要翻译： 提供了组件和方法，用于从患者内要保留的组织的一部分（例如，健康组织）切除要去除的组织的一部分（例如，不健康的组织，例如癌组织）。 诸如盐水的导电流体可以被吸收到亲水电极中。 电能（例如射频（RF）能量）被输送到亲水电极或从亲水电极移动，同时沿着切除线移动到组织附近，由此与切除线相邻的组织凝固。 使用可以与亲水电极在同一装置上的切除部件，例如钝器切除部件或切除电极，沿着切除线分离组织以将要从组织部分移除的组织部分切除到 保留。

公开(公告)号：US20100256625A1

公开(公告)日：2010-10-07

申请号：US12818086

申请日：2010-06-17

申请人： Robert F. Rioux ,  Paul DiCarlo

发明人： Robert F. Rioux ,  Paul DiCarlo

IPC分类号： A61B18/04 ,  G01N23/04

CPC分类号： A61N5/1049 ,  A61B18/1477 ,  A61B18/148 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61N5/1065 ,  A61N2005/1061

摘要： A system and method for treating a target tissue region (e.g., malignant tissue) is provided. A hyperthermic probe is placed into contact with the target tissue region, and the target tissue region is exposed to a therapeutic x-ray radiation beam. The probe is operated to increase the temperature of the target tissue region, thereby facilitating a therapeutic effect of the radiation beam. Image data of the probe containing a fiducial datum is acquired while in contact with the target tissue region, a position of the target tissue region within a treatment coordinate system is determined based on the fiducial datum, and the radiation beam is spatially adjusted relative to the target tissue region based on the determined position of the target tissue region.

摘要翻译： 提供了用于治疗靶组织区域（例如，恶性组织）的系统和方法。 将高温探针放置成与目标组织区域接触，并且将目标组织区域暴露于治疗性X射线辐射束。 操作探针以增加靶组织区域的温度，从而有助于辐射束的治疗效果。 在与目标组织区域接触的同时获取包含基准数据的探针的图像数据，基于基准原理确定处理坐标系内的目标组织区域的位置，并且相对于 基于所确定的目标组织区域的位置的目标组织区域。

公开(公告)号：US07744596B2

公开(公告)日：2010-06-29

申请号：US11250063

申请日：2005-10-13

申请人： Kimbolt Young ,  Steven M. Anderson ,  John Spiridigliozzi ,  Paul DiCarlo

发明人： Kimbolt Young ,  Steven M. Anderson ,  John Spiridigliozzi ,  Paul DiCarlo

IPC分类号： A61B18/18

CPC分类号： A61B18/1477

摘要： A tissue ablation assembly comprises an elongate probe device, at least one ablation electrode element carried by the probe device for conveying ablation energy, and at least one magnetic element for substantially altering the path of the ablation energy conveyed by the electrode element(s). In one embodiment, the magnetic element substantially urges the ablation energy radially outward. In another embodiment, magnetic element takes the form of a ring magnet that exhibits at least four alternating magnetic poles circumferentially disposed around the probe device axis. A method of treating tissue (e.g., a tumor) is also provided. The method comprises introducing a probe device into the patient, conveying ablation energy from the probe device, and applying a magnetic field adjacent the probe device to substantially alter the path of the ablation energy, e.g., by urging the ablation energy conveyed from the probe device radially outward into the tissue to create a tissue lesion, or by urging the ablation energy longitudinally.

摘要翻译： 组织消融组件包括细长探针装置，由探针装置承载的至少一个消融电极元件，用于传送消融能量，以及至少一个磁性元件，用于基本上改变由电极元件传送的消融能量的路径。 在一个实施例中，磁性元件基本上推动消融能量径向向外。 在另一个实施例中，磁性元件呈环形磁铁的形式，其呈现围绕探针器件轴线周向设置的至少四个交变磁极。 还提供了治疗组织（例如肿瘤）的方法。 该方法包括将探针装置引入患者体内，从探针装置输送消融能量，以及施加邻近探针装置的磁场，以基本上改变消融能量的路径，例如通过促使从探针装置传送的消融能量 径向向外进入组织以产生组织损伤，或通过纵向推动消融能量。

公开(公告)号：US07722580B2

公开(公告)日：2010-05-25

申请号：US11265714

申请日：2005-11-02

申请人： Paul Dicarlo ,  Jeff Bean

发明人： Paul Dicarlo ,  Jeff Bean

IPC分类号： A61M5/00

CPC分类号： A61M39/0247 ,  A61M1/3653 ,  A61M1/3659 ,  A61M2039/0273 ,  A61M2039/0285 ,  A61M2039/0288 ,  A61M2039/0294

摘要： A percutaneous port comprises a port body defining a cavity and a first catheter channel adapted to allow passage of a catheter thereinto a shuttle removably received within the cavity, the shuttle including a first flow conduit which, when the shuttle is received within the cavity, extends to the first catheter channel and a sealing mechanism sealing the first flow conduit when a fluid pressure applied thereto is less than a threshold value and opening to permit flow therethrough when the fluid pressure applied thereto is at least the threshold value a cover releasably attachable to the port body to enclose the cavity.

摘要翻译： 经皮端口包括限定空腔的端口主体和适于允许导管通过其中的可移除地容纳在空腔内的梭的第一导管通道，所述梭包括第一流动导管，当梭子被容纳在空腔内时，第一流道延伸 并且当施加到其上的流体压力小于阈值时，所述密封机构密封所述第一流动管道，并且当施加到其上的流体压力至少为阈值时，所述密封机构允许流过其中，所述盖子可释放地附接到所述第一导管通道 端口体以封闭空腔。