公开(公告)号：US20150164798A1

公开(公告)日：2015-06-18

申请号：US14627739

申请日：2015-02-20

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： C. Jeffrey Brinker ,  Carlee Erin Ashley ,  Xingmao Jiang ,  Juewen Liu ,  David S. Peabody ,  Walker Richard Wharton ,  Eric Carnes ,  Bryce Chackerian ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704

CPC classification number: A61K9/127 ,  A61K9/1277 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/513 ,  A61K31/575 ,  A61K31/704 ,  A61K33/24 ,  A61K49/005

Abstract: Various embodiments provide materials and methods for synthesizing protocells for use in targeted delivery of cargo components to cancer cells. In one embodiment, the lipid bilayer can be fused to the porous particle core to form a protocell. The lipid bilayer can be modified with targeting ligands or other ligands to achieve targeted delivery of cargo components that are loaded within the protocell to a target cell, e.g., a type of cancer. Shielding materials can be conjugated to the surface of the lipid bilayer to reduce undesired non-specific binding.

Abstract translation: 各种实施方案提供用于合成原细胞以用于向癌细胞靶向递送货物组分的材料和方法。 在一个实施方案中，脂质双层可以与多孔颗粒核心融合以形成原细胞。 脂质双层可以用靶向配体或其他配体进行修饰，以实现载体在原细胞内的货物组分的靶向递送到靶细胞，例如一种类型的癌症。 屏蔽材料可以结合到脂质双层的表面以减少不期望的非特异性结合。

公开(公告)号：US09059356B1

公开(公告)日：2015-06-16

申请号：US14549233

申请日：2014-11-20

Applicant: Sandia Corporation

Inventor： Mary A. Miller ,  Mary H. Crawford ,  Andrew A. Allerman

IPC: H01L29/06 ,  H01L33/06 ,  H01L33/24 ,  H01L33/32 ,  H01L33/38 ,  H01S5/343 ,  H01S5/042 ,  H01S5/22

CPC classification number: H01L33/06 ,  H01L33/24 ,  H01L33/32 ,  H01L33/38 ,  H01S5/0424 ,  H01S5/0425 ,  H01S5/2275 ,  H01S5/34333

Abstract: A p-type superlattice is used to laterally inject holes into an III-nitride multiple quantum well active layer, enabling efficient light extraction from the active area. Laterally-injected light-emitting diodes and laser diodes can enable brighter, more efficient devices that impact a wide range of wavelengths and applications. For UV wavelengths, applications include fluorescence-based biological sensing, epoxy curing, and water purification. For visible devices, applications include solid state lighting and projection systems.

Abstract translation: 使用p型超晶格将空穴横向注入到III族氮化物多量子阱活性层中，从而能够从有源区域进行有效的光提取。 注入侧面的发光二极管和激光二极管可以实现更广泛，更高效的器件，从而影响广泛的波长和应用。 对于紫外线波长，应用包括基于荧光的生物传感，环氧固化和水净化。 对于可见设备，应用包括固态照明和投影系统。

公开(公告)号：US20150144871A1

公开(公告)日：2015-05-28

申请号：US14549233

申请日：2014-11-20

Applicant: Sandia Corporation

Inventor： Mary A. Miller ,  Mary H. Crawford ,  Andrew A. Allerman

IPC: H01L33/06 ,  H01L33/32 ,  H01S5/22 ,  H01S5/343 ,  H01S5/042 ,  H01L33/24 ,  H01L33/38

CPC classification number: H01L33/06 ,  H01L33/24 ,  H01L33/32 ,  H01L33/38 ,  H01S5/0424 ,  H01S5/0425 ,  H01S5/2275 ,  H01S5/34333

Abstract: A p-type superlattice is used to laterally inject holes into an III-nitride multiple quantum well active layer, enabling efficient light extraction from the active area. Laterally-injected light-emitting diodes and laser diodes can enable brighter, more efficient devices that impact a wide range of wavelengths and applications. For UV wavelengths, applications include fluorescence-based biological sensing, epoxy curing, and water purification. For visible devices, applications include solid state lighting and projection systems.

Abstract translation: 使用p型超晶格将空穴横向注入到III族氮化物多量子阱活性层中，从而能够从有源区域进行有效的光提取。 注入侧面的发光二极管和激光二极管可以实现更广泛，更高效的器件，从而影响广泛的波长和应用。 对于紫外线波长，应用包括基于荧光的生物传感，环氧固化和水净化。 对于可见设备，应用包括固态照明和投影系统。

公开(公告)号：US09029807B1

公开(公告)日：2015-05-12

申请号：US13834227

申请日：2013-03-15

Applicant: Sandia Corporation

Inventor： Patrick L. Feng ,  Joseph G. Cordaro ,  Mitchell R. Anstey ,  Alfredo M. Morales

IPC: C09K11/06 ,  G01T1/204

CPC classification number: C09K11/06 ,  G01T1/204

Abstract: A composition capable of producing a unique scintillation response to neutrons and gamma rays, comprising (i) at least one surfactant; (ii) a polar hydrogen-bonding solvent; and (iii) at least one luminophore. A method including combining at least one surfactant, a polar hydrogen-bonding solvent and at least one luminophore in a scintillation cell under vacuum or an inert atmosphere.

Abstract translation: 能够产生对中子和γ射线的独特闪烁响应的组合物，其包含（i）至少一种表面活性剂; （ii）极性氢键合溶剂; 和（iii）至少一个发光体。 一种方法，包括在真空或惰性气氛下将闪烁体中的至少一种表面活性剂，极性氢键合溶剂和至少一种发光体组合。

公开(公告)号：US09029239B2

公开(公告)日：2015-05-12

申请号：US14067433

申请日：2013-10-30

Applicant: Sandia Corporation

Inventor： Anna Tauke-Pedretti ,  Gregory N. Nielson ,  Jeffrey G. Cederberg ,  Jose Luis Cruz-Campa

IPC: H01L21/46 ,  H01L31/0735 ,  H01L31/18

CPC classification number: H01L31/18 ,  H01L21/7806 ,  H01L31/0735 ,  H01L31/1852 ,  H01L31/1892 ,  Y02E10/52 ,  Y02E10/544

Abstract: A method includes etching a release layer that is coupled between a plurality of semiconductor devices and a substrate with an etch. The etching includes etching the release layer between the semiconductor devices and the substrate until the semiconductor devices are at least substantially released from the substrate. The etching also includes etching a protuberance in the release layer between each of the semiconductor devices and the substrate. The etch is stopped while the protuberances remain between each of the semiconductor devices and the substrate. The method also includes separating the semiconductor devices from the substrate. Other methods and apparatus are also disclosed.

Abstract translation: 一种方法包括用蚀刻来蚀刻耦合在多个半导体器件和衬底之间的释放层。 蚀刻包括蚀刻半导体器件和衬底之间的释放层，直到半导体器件至少基本上从衬底上释放出来。 蚀刻还包括在每个半导体器件和衬底之间的剥离层中蚀刻突起。 在每个半导体器件和衬底之间保持突起的同时停止蚀刻。 该方法还包括从衬底分离半导体器件。 还公开了其它方法和装置。

公开(公告)号：US20150114444A1

公开(公告)日：2015-04-30

申请号：US14061946

申请日：2013-10-24

Applicant: Sandia Corporation

Inventor： Anthony L. Lentine ,  Gregory N. Nielson ,  Anna Tauke-Pedretti ,  Joseq Luis Cruz-Campa ,  Murat Okandan

IPC: H01L31/05

CPC classification number: H01L31/05 ,  H01L31/042 ,  H01L31/044 ,  Y02E10/50

Abstract: A photovoltaic power generation system that includes a solar panel is described herein. The solar panel includes a photovoltaic sub-module, which includes a group of microsystem enabled photovoltaic cells. The group includes a first string of photovoltaic cells, a second string of photovoltaic cells, and a differing photovoltaic cell. Photovoltaic cells in the first string are electrically connected in series, and photovoltaic cells in the second string are electrically connected in series. Further, the first string of photovoltaic cells, the second string of photovoltaic cells, and the differing photovoltaic cell are electrically connected in parallel. Moreover, the differing photovoltaic cell is used as a bypass diode for the first string of photovoltaic cells and the second string of photovoltaic cells.

Abstract translation: 本文描述了包括太阳能电池板的光伏发电系统。 太阳能电池板包括光伏子模块，其包括一组支持微系统的光伏电池。 该组包括第一串光伏电池，第二串光伏电池和不同的光伏电池。 第一串中的光伏电池串联电连接，并且第二串中的光伏电池串联电连接。 此外，第一串光伏电池，第二串太阳能电池和不同的光伏电池并联电连接。 此外，不同的光伏电池用作第一串光伏电池和第二串光伏电池的旁路二极管。

公开(公告)号：US20150112905A1

公开(公告)日：2015-04-23

申请号：US14521194

申请日：2014-10-22

Applicant: Sandia Corporation

Inventor： Nadine E. Miner ,  John H. Gauthier ,  Michael L. Wilson ,  Hai D. Le ,  Dennis E. Longsine

IPC: G06N5/04 ,  G06N99/00

CPC classification number: G06N7/00 ,  G06N20/00 ,  G06Q10/0637 ,  G06Q10/067

Abstract: Methods, systems and computer program products to evaluate or assess strategies for operating and designing complex systems, including systems of systems, are disclosed. The methods, systems and computer program products provide describe and evaluate the behavior of systems in real-world environments where future conditions are highly uncertain are disclosed. The present disclosure identifies a set of important strategies, a set of concomitant actions, and a set of environmental conditions that form the basis of strategic change rules. These rules can be incorporated in a simulation to modify the behavior of the simulated system. These methods, systems and computer program products offers a capability, which has not been previously available, to evaluate the adaptability of complex systems

Abstract translation: 公开了用于评估或评估操作和设计复杂系统（包括系统系统）的策略的方法，系统和计算机程序产品。 方法，系统和计算机程序产品提供了描述和评估系统在现实环境中的行为，其中未来条件是非常不确定的。 本披露确定了一套重要的战略，一套伴随的行动以及形成战略变革规则基础的一套环境条件。 这些规则可以并入模拟中以修改模拟系统的行为。 这些方法，系统和计算机程序产品提供了一种以前没有可用的能力来评估复杂系统的适应性

公开(公告)号：US20150112904A1

公开(公告)日：2015-04-23

申请号：US14521091

申请日：2014-10-22

Applicant: Sandia Corporation

Inventor： John H. Gauthier ,  Nadine E. Miner ,  Michael L. Wilson ,  Gio K. Kao ,  Hai D. Le ,  Darryl J. Melander

IPC: G06N5/04 ,  G06N99/00 ,  G06Q10/06

Abstract: Methods, systems and computer program products to measure the adaptability of complex systems, including systems of systems, are disclosed. The methods, systems and computer program products provide rigor and defensibility to the analysis and assessment of adaptability. As a result, systems can be designed or acquired that are intrinsically more adaptable and better able to respond to changing environments.

Abstract translation: 公开了用于测量包括系统系统在内的复杂系统的适应性的方法，系统和计算机程序产品。 方法，系统和计算机程序产品对适应性的分析和评估提供了严格和防御性。 因此，可以设计或获取本质上更适应和更好地响应不断变化的环境的系统。

公开(公告)号：US08961766B2

公开(公告)日：2015-02-24

申请号：US13960608

申请日：2013-08-06

Applicant: Sandia Corporation

Inventor： Amy E. Herr ,  Anup K. Singh ,  Daniel J. Throckmorton

IPC: G01N27/447 ,  G01N33/543 ,  G01N33/561 ,  B01L3/00

CPC classification number: G01N27/44747 ,  B01L3/502753 ,  G01N27/44791 ,  G01N33/54306 ,  G01N33/561

Abstract: A micro-analytical platform for performing electrophoresis-based immunoassays was developed by integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device. The microfluidic immunoassays are performed by gel electrophoretic separation and quantifying analyte concentration based upon conventional polyacrylamide gel electrophoresis (PAGE). To retain biological activity of proteins and maintain intact immune complexes, native PAGE conditions were employed. Both direct (non-competitive) and competitive immunoassay formats are demonstrated in microchips for detecting toxins and biomarkers (cytokines, c-reactive protein) in bodily fluids (serum, saliva, oral fluids). Further, a description of gradient gels fabrication is included, in an effort to describe methods we have developed for further optimization of on-chip PAGE immunoassays. The described chip-based PAGE immunoassay method enables immunoassays that are fast (minutes) and require very small amounts of sample (less than a few microliters). Use of microfabricated chips as a platform enables integration, parallel assays, automation and development of portable devices.

Abstract translation: 通过将光聚合的交联聚丙烯酰胺凝胶整合到微流体装置内，开发了用于进行基于电泳的免疫测定的微分析平台。 通过凝胶电泳分离和定量基于常规聚丙烯酰胺凝胶电泳（PAGE）的分析物浓度进行微流体免疫测定。 为了保持蛋白质的生物活性并保持完整的免疫复合物，采用天然PAGE条件。 用于检测体液（血清，唾液，口服液）中的毒素和生物标志物（细胞因子，c反应蛋白）的微芯片都展示了直接（非竞争性）和竞争性免疫测定形式。 此外，包括梯度凝胶制造的描述，以努力描述我们为进一步优化片上PAGE免疫测定而开发的方法。 所述基于片段的PAGE免疫测定方法使得能够快速（几分钟）并且需要非常少量的样品（少于几微升）的免疫测定。 使用微加工芯片作为平台，可实现便携式设备的集成，并行测定，自动化和开发。

公开(公告)号：US20150024414A1

公开(公告)日：2015-01-22

申请号：US14157378

申请日：2014-01-16

Applicant: Sandia Corporation

Inventor： Jason C. Harper ,  Thayne L. Edwards ,  Bryan Carson ,  Melissa Finley ,  William Arndt

IPC: G01N33/569

CPC classification number: G01N33/56911 ,  B01L3/502738 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0633 ,  F16K31/086 ,  F16K99/003 ,  F16K99/0046 ,  F16K2099/0084 ,  Y10T137/87917

Abstract: The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force. The valve element includes a magnetic material or metal. Such apparatuses and methods are useful for in-field or real-time detection of targets, especially in limited resource settings.

Abstract translation: 本发明部分地涉及用于片上放大和/或检测各种靶标的方法和装置，包括生物靶标和任何可扩增的靶标。 在一些实例中，微培养装置包括一次性常闭的流体阀，其最初通过结合到粘合剂涂层的阀元件保持在关闭位置。 阀门使用磁力打开。 阀元件包括磁性材料或金属。 这样的设备和方法对于现场或实时检测目标是有用的，特别是在有限的资源设置中。