-
公开(公告)号:US20200091677A1
公开(公告)日:2020-03-19
申请号:US16131842
申请日:2018-09-14
申请人: Toyota Motor Engineering & Manufacturing North America, Inc. , University of Ottawa , Broadcom Inc.
发明人: Ercan M. Dede , Christopher Valdivia , Matthew Wilkins , Karin Hinzer , Philippe-Olivier Provost , Denis Masson , Simon Fafard
摘要: An optical power transfer device with an embedded active cooling chip is disclosed. The device includes a cooling chip made of a semiconductor material, and a first subassembly and a second subassembly mounted on the cooling chip. The cooling chip comprises at least one metallization layer on a portion of a first surface of the cooling chip, at least one inlet through a second surface of the cooling chip, wherein the second surface is opposite to the first surface, at least one outlet through the second surface and one or more micro-channels extending between and fluidly coupled to the at least one inlet and the at least one outlet. A cooling fluid flows through the one or more micro-channels. The first subassembly is mounted on the at least one metallization layer and comprises a laser. The second subassembly comprises a phototransducer configured to receive a laser beam from the laser.
-
公开(公告)号:US10591485B2
公开(公告)日:2020-03-17
申请号:US15004264
申请日:2016-01-22
申请人: UNIVERSITY OF OTTAWA
摘要: There are provided dicysteine peptide tags for use with dimaleimide fluorescent labelling agents for the labelling and detection of specific protein targets. Peptide tags comprising the amino acid sequence set forth in SEQ ID NO: 2 are described. L1SX3AECAAX9EAACREX16X17ARAGGK23 (SEQ ID NO: 2)
-
公开(公告)号:US20200010776A1
公开(公告)日:2020-01-09
申请号:US16494936
申请日:2018-03-15
申请人: University of Ottawa
发明人: Derek Andrew PRATT , Evan HAIDASZ
IPC分类号: C10M169/04 , C07D498/04 , C07D513/04 , C07D513/14 , C10M133/48 , C10M135/36
摘要: The present disclosure relates generally to antioxidants. More particularly, the present disclosure relates to lubricating compositions comprising an antioxidant.
-
公开(公告)号:US20190389814A1
公开(公告)日:2019-12-26
申请号:US16093751
申请日:2017-04-13
IPC分类号: C07D241/04 , C07D405/06 , C07C317/36
摘要: There are provided Tissue Transglutaminase (TG2) inhibitor compounds, and compositions and methods of use thereof for the prevention or treatment of a cancer. Compounds of Formula I, and pharmaceutically acceptable salts thereof, are provided:
-
公开(公告)号:US10301659B2
公开(公告)日:2019-05-28
申请号:US15354603
申请日:2016-11-17
发明人: Dennis M. Whitfield , Susan M. Logan , Ian C. Schoenhofen , Christopher N. Boddy , Benjamin R. Lundgren
摘要: The present invention relates to the cell-based production of bacterial nonulosonates and their biosynthetic precursors. Specifically, the present invention provides recombinant cells for the production of pseudaminic acid, legionaminic acid, UDP-2,4-diacetamido-2,4,6-trideoxy-β-L-altropyranose, and UDP-2,4-diacetamido-2,4,6-trideoxy-α-D-glucopyranose. Methods for producing the sugars are also provided.
-
公开(公告)号:US10228379B2
公开(公告)日:2019-03-12
申请号:US15990734
申请日:2018-05-28
申请人: UNIVERSITY OF OTTAWA
摘要: There is provided protein biomarkers and methods for their use in diagnosing and treating Inflammatory Bowel Disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) as well as methods for assessing the severity of the diseases.
-
公开(公告)号:US10023918B2
公开(公告)日:2018-07-17
申请号:US14774838
申请日:2014-03-14
申请人: UNIVERSITY OF OTTAWA
发明人: Alain Stintzi , David R. Mack , Daniel Figeys , Walid Abdelfattah Elsayed Mottawea , Turki Saleh A. Abujamel , Cheng-kang Chiang
IPC分类号: C12Q1/68 , C12P19/34 , C12Q1/689 , C12Q1/04 , G01N33/569 , C12Q1/6883 , A61K45/06 , A61K31/00 , A61K33/24 , A61K31/555 , C12Q1/06
摘要: There is provided methods and compositions to diagnose, classify and treat inflammatory bowel disease including ulcerative colitis and Crohn's disease by measuring the levels of certain bacterial taxa and proteins collected from the gut.
-
公开(公告)号:US10001493B2
公开(公告)日:2018-06-19
申请号:US15477508
申请日:2017-04-03
申请人: UNIVERSITY OF OTTAWA
IPC分类号: G01N33/68
CPC分类号: G01N33/6893 , A61K45/06 , G01N2333/47 , G01N2333/902 , G01N2333/91142 , G01N2333/914 , G01N2800/065
摘要: There is provided protein biomarkers and methods for their use in diagnosing and treating Inflammatory Bowel Disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) as well as methods for assessing the severity of the diseases.
-
公开(公告)号:US20180022729A1
公开(公告)日:2018-01-25
申请号:US15548512
申请日:2016-02-05
IPC分类号: C07D401/12 , C07D239/42 , C07D213/74 , A61K8/49 , C08K5/3462 , C10L1/232 , C10M133/40 , C07D239/48 , C08K5/3432
CPC分类号: C07D401/12 , A61K8/4926 , A61K8/4953 , A61K2800/10 , A61K2800/522 , A61Q19/00 , C07D213/74 , C07D239/42 , C07D239/48 , C08K5/34 , C08K5/3432 , C08K5/3462 , C09D7/40 , C09D11/00 , C09J11/06 , C09K15/18 , C09K15/30 , C10L1/106 , C10L1/1233 , C10L1/232 , C10L10/00 , C10L2200/0476 , C10L2230/08 , C10L2270/026 , C10M133/40 , C10M141/06 , C10M2201/062 , C10M2207/026 , C10M2207/401 , C10M2207/402 , C10M2215/064 , C10M2215/221 , C10N2210/01 , C10N2210/02 , C10N2230/10 , C10N2240/04 , C10N2240/042 , C10N2240/08 , C10N2240/10
摘要: A method of preventing or reducing the level of degradation of an organic substrate is described, wherein a composition is formed that includes the organic substrate together with an effective amount of a sacrificial base and a diarylamine antioxidant.
-
公开(公告)号:US20170233723A1
公开(公告)日:2017-08-17
申请号:US15451716
申请日:2017-03-07
申请人: University of Ottawa
发明人: Maxim V. Berezovski , Mohamed Wehbe , Mahmoud Aziz Mahmoud Labib , Darija Muharemagic , Anna S. Zamay , Shahrokh Ghobadloo
IPC分类号: C12N15/10 , C12N15/115
CPC分类号: C12N15/1048 , C07K1/14 , C12N7/00 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/13 , C12N2760/20051 , C12N2760/20251
摘要: The disclosure relates to a switchable aptamer having a high affinity for a selected target such as a virus, cell or antibody when in the presence of a binding ion and a low affinity for said target in the absence of said binding ion. The switchable aptamer may be isolated or selected from a pool comprising a mixture of aptamers by incubating the pool with the target ligand and a binding ion to form target-aptamer complexes; separating unbound aptamer molecules from the target-aptamer complexes; contacting the target-aptamer complexes with a chelating agent having affinity for the binding ion wherein a switchable aptamer specific to said target is released from the target-aptamer complexes; and isolating the switchable aptamer released in the preceding step.
-
-
-
-
-
-
-
-
-