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公开(公告)号：US10098764B2
公开(公告)日：2018-10-16
申请号：US15132973
申请日：2016-04-19
发明人： Stephen D. Pacetti
摘要： An implantable sent comprises a radiopaque marker that provides a structural connection between two parts made of a polymer substrate material. The two parts can be one bending element of one radially expandable ring and another bending element of an adjacent expandable ring. The two parts can be two bending elements of the same radially expandable ring. The radiopaque marker can be in the form of an entire radially expandable ring.
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公开(公告)号：US10076591B2
公开(公告)日：2018-09-18
申请号：US15192973
申请日：2016-06-24
CPC分类号： A61L31/148 , A61L31/10 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
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公开(公告)号：US09908297B2
公开(公告)日：2018-03-06
申请号：US14831693
申请日：2015-08-20
CPC分类号： B29C69/001 , A61F2/91 , A61F2/915 , A61F2002/91575 , A61F2230/0006 , A61F2250/0036 , A61F2250/0098 , B29C49/4268 , B29C2793/0063 , B29L2031/7546
摘要： A scaffold strut is shaped to improve hemocompatibility. The scaffold is made from a tube having variable wall thickness. Methods are disclosed for modifying the thickness of the tube in such a way as to achieve a reduced hemodynamic profile, but without significantly affecting strength properties in areas where stress concentrations exist when the scaffold is loaded.
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公开(公告)号：US09901663B2
公开(公告)日：2018-02-27
申请号：US14267620
申请日：2014-05-01
发明人： Stephen D. Pacetti , Ni Ding
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0067 , A61F2250/0068 , A61L27/50 , A61L27/505 , A61L27/54 , A61L31/022 , A61L31/143 , A61L2300/00 , A61L2300/416 , A61L2300/426 , A61L2300/604 , A61L2300/802 , B65B3/003 , Y10T29/49993
摘要： A composition for loading into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and a chelator, a precipitation agent, or a combination thereof. Medical devices, such as stents, with a structural element defined by a lumen and at least one opening to access the lumen, filled with the compositions are also described.
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公开(公告)号：US09895244B2
公开(公告)日：2018-02-20
申请号：US14979297
申请日：2015-12-22
发明人： John E. Papp , Hung T. Nguyen , Justin K. Elerath , Dion I. Herabadi , Michael T. Martins , Kirsten S. King , Scott H. Mueller , Coeta K. Peloquin , Stephen D. Pacetti
CPC分类号： A61F2/958 , A61F2/844 , A61F2/91 , A61F2/915 , A61F2/966 , A61F2002/826 , A61F2002/9583 , A61F2210/0076 , A61F2250/0019 , A61F2250/0039
摘要： Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps. When the balloon is inflated the gaps between the disconnected scaffold segments stay constant. Pillowed or banded balloons are used to deliver the segments.
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公开(公告)号：US20170296365A1
公开(公告)日：2017-10-19
申请号：US15429339
申请日：2017-02-10
发明人： Pamela A. Kramer-Brown , Kayla L. Calvert , John A. Simpson , Stephen D. Pacetti , Austin M. Leach
CPC分类号： A61F2/82 , A61F2/06 , A61F2250/0098 , A61L31/022 , A61L31/18 , C22C1/0433 , C22C19/05 , C22C19/07 , C22C27/00 , C22C27/04 , C22C27/06
摘要： Embodiments are directed to radiopaque implantable structures (e.g., stents) formed of cobalt-based alloys that comprise cobalt, chromium and one or more platinum group metals, refractory metals, precious metals, or combinations thereof. Platinum group metals include platinum, palladium, ruthenium, rhodium, osmium, and iridium. Refractory metals include zirconium, niobium, rhodium, molybdenum, hafnium, tantalum, tungsten, rhenium, and precious metals include silver and gold. In one embodiment, the one or more included platinum group or refractory metals substitute at least partially for nickel, such that the alloy exhibits reduced nickel content, or is substantially nickel free. The stents exhibit improved radiopacity as compared to similar alloys including greater amounts of nickel.
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公开(公告)号：US09737641B2
公开(公告)日：2017-08-22
申请号：US15445670
申请日：2017-02-28
发明人： Stephen D. Pacetti , Julia Fox
IPC分类号： A61F13/00 , A61K31/44 , B65B55/18 , B23P25/00 , A61L31/08 , A61K31/436 , A61L31/16 , A61L31/14
CPC分类号： A61L31/08 , A61K31/436 , A61L31/143 , A61L31/16 , A61L2300/416 , A61L2420/02 , B65B55/12 , Y10T29/49885
摘要： This invention relates to an method of manufacture of an implantable medical device comprising an oxygen-sensitive rapamycin derivative that is protected by addition of an antioxidant during the manufacturing process where the amount of antioxidant added at the outset of the processing is such that when the device is fully fabricated, sterilized and packaged the amount of antioxidant has reduced to a minimal, preferably non-detect, amount.
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公开(公告)号：US09713542B2
公开(公告)日：2017-07-25
申请号：US15064262
申请日：2016-03-08
发明人： Stephen D. Pacetti , Yunbing Wang
IPC分类号： A61F2/86 , A61F2/915 , A61L31/12 , A61F2/82 , C23C8/00 , C23C8/42 , C23C8/80 , C23C8/10 , C23C26/00 , C23C28/04 , C23C28/00 , C23C30/00 , A61L31/02 , A61L31/08 , A61L31/10 , A61L31/14 , B22D21/00 , B22D25/02 , B22D27/00 , B23K26/38 , B23K26/40 , B23K103/08
CPC分类号： A61F2/915 , A61F2/82 , A61F2210/0004 , A61F2210/0009 , A61F2240/001 , A61F2250/003 , A61F2310/00041 , A61L31/022 , A61L31/086 , A61L31/088 , A61L31/10 , A61L31/124 , A61L31/148 , A61L2300/416 , A61L2300/606 , A61L2400/18 , B22D21/007 , B22D25/02 , B22D27/00 , B23K26/38 , B23K26/40 , B23K2103/15 , C23C8/00 , C23C8/10 , C23C8/42 , C23C8/80 , C23C26/00 , C23C28/04 , C23C28/30 , C23C30/00
摘要： Stents or scaffolds made from magnesium or magnesium alloys including additives or barrier coatings that modify the corrosion rate of the stent are disclosed. Methods of forming barrier coatings that modify the corrosion rate of the stent are disclosed.
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公开(公告)号：US09474834B2
公开(公告)日：2016-10-25
申请号：US14251536
申请日：2014-04-11
CPC分类号： A61L31/10 , A61L31/08 , A61L31/16 , A61L33/128 , A61L2300/252 , A61L2300/42 , A61L2420/02 , C08L89/00
摘要： Coatings for medical devices, the coatings including albumin, the methods of forming the coatings, and the coated medical devices are disclosed. In preferred embodiments the medical device is a bioabsorbable stent. The albumin coating layer improves the thromboresistance of the device.
摘要翻译： 公开了用于医疗装置的涂层，包括白蛋白的涂层，形成涂层的方法和涂覆的医疗装置。 在优选实施例中，医疗装置是生物可吸收支架。 白蛋白涂层改善了该装置的血栓阻力。
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100.发明授权公开(公告)号：US09381280B2
公开(公告)日：2016-07-05
申请号：US14304792
申请日：2014-06-13
IPC分类号： C08F6/00 , A61L31/14 , A61L31/06 , C08J3/18 , C08J9/00 , B29C45/00 , B29C71/00 , B29C71/02 , C08J3/00 , B29K33/04 , B29L31/00
CPC分类号： A61L31/141 , A61L31/06 , A61L31/148 , A61L2400/00 , B29C45/0053 , B29C45/72 , B29C71/0009 , B29C71/02 , B29C2071/0027 , B29C2071/022 , B29K2033/04 , B29K2067/04 , B29L2031/753 , C08J3/18 , C08J9/00 , C08J2207/10 , C08J2300/16 , C08K5/0016
摘要： Methods of making polymeric devices, such as stents, with one or more modifications such as addition of plasticizers, to improve processing, and the devices made by these methods.
摘要翻译： 制备聚合物装置（例如支架）的方法，具有一种或多种改性，例如添加增塑剂以改善加工，以及通过这些方法制备的装置。
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