公开(公告)号：US20050129614A1

公开(公告)日：2005-06-16

申请号：US10943197

申请日：2004-09-17

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C07K16/28 ,  C12N5/24 ,  A61K51/00 ,  A61K39/395 ,  C07K16/30 ,  C07K16/46

CPC分类号： C07K16/2875 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76

摘要： The present invention relates to antibodies and related molecules that specifically bind to TL5. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy. The invention also relates to nucleic acid molecules encoding anti-TL5 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer as well as immune system diseases and disorders including autoimmune disease, rheumatoid arthritis, graft rejection, graft vs. host disease, and lymphadenopathy, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to TL5.

摘要翻译： 本发明涉及特异性结合TL5的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括自身免疫疾病，类风湿性关节炎，移植物排斥，移植物抗宿主病和淋巴结病的免疫系统疾病和病症。 本发明还涉及编码抗TL5抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及包括自身免疫性疾病，类风湿性关节炎，移植排斥反应，移植物抗宿主病和免疫系统疾病和病症的方法和组合物。 淋巴腺病，包括向动物，优选人类施用有效量的特异性结合TL5的一种或多种抗体或其片段或变体或相关分子。

公开(公告)号：US20070292411A1

公开(公告)日：2007-12-20

申请号：US11745734

申请日：2007-05-08

申请人： Theodora Salcedo ,  Viktor Roschke ,  Steven Ruben ,  Craig Rosen

发明人： Theodora Salcedo ,  Viktor Roschke ,  Steven Ruben ,  Craig Rosen

IPC分类号： A61K39/395 ,  A61P43/00 ,  C07K16/28 ,  C12N5/06 ,  C12N5/12 ,  C12P21/08 ,  G01N33/53

CPC分类号： G01N33/57411 ,  A61K2039/505 ,  C07K16/2878 ,  C07K2317/73 ,  G01N33/57419

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.

摘要翻译： 本发明涉及免疫特异性结合TRAIL受体的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TRAIL受体抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体的相关分子。

公开(公告)号：US20070042361A1

公开(公告)日：2007-02-22

申请号：US10472963

申请日：2002-03-26

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/574 ,  A61K38/17

CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/393 ,  Y02A50/395

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗癌症及其它过度增殖性疾病和病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070041963A1

公开(公告)日：2007-02-22

申请号：US11001793

申请日：2004-12-02

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  A61K39/395 ,  A61K48/00 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating diseases, disorders, and/or conditions related to said human secreted proteins. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

公开(公告)号：US20070032414A1

公开(公告)日：2007-02-08

申请号：US10472964

申请日：2002-03-26

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K38/17

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  G01N2800/32

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞和用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20070031842A1

公开(公告)日：2007-02-08

申请号：US10670186

申请日：2003-09-25

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/705 ,  C07K14/47 ,  C07K16/18 ,  C12N9/00

CPC分类号： C07K14/47 ,  A61K38/17

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060228359A1

公开(公告)日：2006-10-12

申请号：US11381977

申请日：2006-05-05

申请人： Reiner Gentz ,  Brent Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrik ,  Pablo Jimenez ,  Vikram Patel ,  Craig Rosen ,  Mark Adams ,  Haodong Li ,  Steven Ruben

发明人： Reiner Gentz ,  Brent Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrik ,  Pablo Jimenez ,  Vikram Patel ,  Craig Rosen ,  Mark Adams ,  Haodong Li ,  Steven Ruben

IPC分类号： A61K39/395 ,  G01N33/53 ,  C12N5/06 ,  C07K16/24

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US20060223088A1

公开(公告)日：2006-10-05

申请号：US11346470

申请日：2006-02-03

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C07K14/74 ,  C07K16/42 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating immune disorders and diseases. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽和编码所述多肽的分离的核酸分子，其可用于诊断和治疗免疫疾病和疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060194735A1

公开(公告)日：2006-08-31

申请号：US11429276

申请日：2006-05-08

申请人： Craig Rosen ,  William Haseltine ,  David Ballance ,  Andrew Turner ,  Steven Ruben

发明人： Craig Rosen ,  William Haseltine ,  David Ballance ,  Andrew Turner ,  Steven Ruben

IPC分类号： A61K38/38 ,  C07H21/04 ,  C12P21/04 ,  C07K14/765

CPC分类号： C07K14/765 ,  A61K31/155 ,  A61K31/426 ,  A61K31/4439 ,  A61K31/4965 ,  A61K38/00 ,  A61K38/04 ,  A61K38/17 ,  A61K38/28 ,  A61K39/21 ,  C07K7/06 ,  C07K14/005 ,  C07K14/435 ,  C07K14/4713 ,  C07K14/4723 ,  C07K14/475 ,  C07K14/50 ,  C07K14/505 ,  C07K14/51 ,  C07K14/521 ,  C07K14/525 ,  C07K14/535 ,  C07K14/54 ,  C07K14/5406 ,  C07K14/55 ,  C07K14/555 ,  C07K14/56 ,  C07K14/565 ,  C07K14/575 ,  C07K14/57563 ,  C07K14/5759 ,  C07K14/585 ,  C07K14/59 ,  C07K14/60 ,  C07K14/605 ,  C07K14/61 ,  C07K14/62 ,  C07K14/635 ,  C07K14/65 ,  C07K14/655 ,  C07K14/665 ,  C07K14/705 ,  C07K14/7151 ,  C07K14/82 ,  C07K16/00 ,  C07K16/241 ,  C07K16/26 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/30 ,  C07K2319/31 ,  C12N7/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N15/62 ,  C12N2501/335 ,  C12N2740/16111 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16171 ,  C12Y101/01105 ,  C12Y102/01 ,  C12Y207/01095

摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disordrs or conditions using albumin fusion proteins of the invention.

公开(公告)号：US20050129699A1

公开(公告)日：2005-06-16

申请号：US10986047

申请日：2004-11-12

申请人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

发明人： Theodora Salcedo ,  Steven Ruben ,  Craig Rosen ,  Vivian Albert

IPC分类号： A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  C07K16/30 ,  G01N33/574

CPC分类号： A61K39/395 ,  A61K31/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/565 ,  C07K2317/622 ,  A61K2300/00

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4i. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4i的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段 或其变体，或免疫特异性结合TRAIL受体TR4的相关分子。