公开(公告)号：US20180236484A1

公开(公告)日：2018-08-23

申请号：US15435318

申请日：2017-02-17

申请人： David Brown

发明人： David Brown

IPC分类号： B05D1/06

CPC分类号： C01G23/053 ,  C01B33/18 ,  C01G49/06 ,  C01P2002/60 ,  C01P2004/61 ,  C01P2004/62 ,  G02B6/02395 ,  Y02P40/57

摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or

公开(公告)号：US09399529B2

公开(公告)日：2016-07-26

申请号：US13810620

申请日：2011-08-09

申请人： Stephen Derby ,  John McFadden ,  David Brown ,  Eugene Eckert

发明人： Stephen Derby ,  John McFadden ,  David Brown ,  Eugene Eckert

IPC分类号： B65B5/08 ,  B65B35/24 ,  B65G47/26 ,  B65B35/30 ,  B65B3/00 ,  B65B5/10 ,  B65B61/28 ,  B65G15/44 ,  B65G47/51 ,  B65G47/52

CPC分类号： B65B3/00 ,  B65B5/105 ,  B65B35/246 ,  B65B61/28 ,  B65B2220/18 ,  B65G15/44 ,  B65G47/5118 ,  B65G47/52

摘要： The system (30) includes a product engager (32), a transporter (34) and a patterned depositor (36) for engaging products (38) and transporting the products (38) from the product engager (32) to the patterned depositor (36), such as between a product bagging machine (56) that forms and fills a bag (24), a conveyor that transports the bags as the products (38) and delivers them to a case packing machine as the patterned depositor (36). The product engager (32) and the patterned depositor (36) include first and second drivers (46, 48) and the transporter (34) includes an adjustable-length buffer (50) to compensate for any temporary difference between a first product delivery rate of the product engager (32) and a rate of movement of the products (38) passing from the product engager (32) along the transporter (34) to the patterned depositor (36).

摘要翻译： 系统（30）包括产品收集器（32），运送器（34）和图案化存放器（36），用于接合产品（38）并将产品（38）从产品收集器（32）运送到图案化存放器 36），例如在形成并填充袋（24）的产品包装机（56）之间，作为产品（38）运输袋并将其作为图案化存放器（36）输送到包装机的输送机， 。 产品收集器（32）和图案化存储器（36）包括第一和第二驱动器（46,48），并且运输器（34）包括可调节长度的缓冲器（50），以补偿第一产品传送速率 （32）的产品（38）的运动速率以及从产品接合器（32）沿着运送器（34）传送到图案化存放器（36）的运动速率。

公开(公告)号：US09384499B2

公开(公告)日：2016-07-05

申请号：US13299732

申请日：2011-11-18

申请人： Garry Lyons ,  David Brown ,  Michael Clay Atkins ,  Oran Cummins ,  Daniel Martin ,  Alan Cooke ,  Stephen Elder

发明人： Garry Lyons ,  David Brown ,  Michael Clay Atkins ,  Oran Cummins ,  Daniel Martin ,  Alan Cooke ,  Stephen Elder

IPC分类号： G06Q30/06 ,  G06F15/16 ,  G06Q30/02

CPC分类号： G06Q30/0261 ,  G06Q30/0224 ,  G06Q30/0255 ,  G06Q30/0643

摘要： A method for indirectly controlling a website using a user communication device is disclosed. A unique machine-readable code is displayed on a display device, the unique machine-readable code being specific to the display device displaying contents from a website through a server. The unique machine-readable code is readable by a user communication device, the user communication device in turn being able to communicate with the server through a communication path not involving an input device associated with the display device. Commands to control content displayed through the server are received from the user communication device. The commands include the identity of the specific display device by the displayed unique machine readable code. The content displayed on the specific display device is then changed accordingly.

摘要翻译： 公开了一种使用用户通信设备间接控制网站的方法。 独特的机器可读代码显示在显示设备上，独特的机器可读代码特定于显示设备，通过服务器从网站显示内容。 唯一的机器可读代码可由用户通信设备读取，用户通信设备又能够通过不涉及与显示设备相关联的输入设备的通信路径与服务器进行通信。 从用户通信设备接收到控制通过服务器显示的内容的命令。 这些命令包括所显示的唯一机器可读代码的特定显示设备的身份。 然后，相应地改变在特定显示装置上显示的内容。

公开(公告)号：US08946177B2

公开(公告)日：2015-02-03

申请号：US13299255

申请日：2011-11-17

申请人： David Brown ,  Lance Ford ,  Angie Cheng ,  Rich Jarvis ,  Mike Byrom ,  Dmitriy Ovcharenko ,  Eric Devroe ,  Kevin Kelnar

发明人： David Brown ,  Lance Ford ,  Angie Cheng ,  Rich Jarvis ,  Mike Byrom ,  Dmitriy Ovcharenko ,  Eric Devroe ,  Kevin Kelnar

IPC分类号： C12N15/11 ,  C12Q1/68 ,  C12N15/113

CPC分类号： C12N15/113 ,  A61K9/127 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/111 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/312 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/344 ,  C12N2310/35 ,  C12N2310/351 ,  C12N2310/3527 ,  C12N2310/3535 ,  C12N2310/533 ,  C12N2320/12 ,  C12N2320/30 ,  C12N2320/50 ,  C12N2330/10 ,  C12Q1/68 ,  C12Q1/6876 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12N2310/3521

摘要： The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.

公开(公告)号：US08887713B2

公开(公告)日：2014-11-18

申请号：US13650535

申请日：2012-10-12

申请人： Felicity Cutts ,  Jorge Fernandez De Castro ,  John V. Bennett ,  Beth Laube ,  Clyde Witham ,  Ana Maria Henao-Restrepo ,  Bernard Cohen ,  David Brown ,  John Dennis

发明人： Felicity Cutts ,  Jorge Fernandez De Castro ,  John V. Bennett ,  Beth Laube ,  Clyde Witham ,  Ana Maria Henao-Restrepo ,  Bernard Cohen ,  David Brown ,  John Dennis

IPC分类号： A61M11/00 ,  A61M16/10 ,  A61M11/02 ,  A61M16/00 ,  A61M15/00 ,  A61M16/06

CPC分类号： A61M11/02 ,  A61M11/005 ,  A61M15/0086 ,  A61M16/0045 ,  A61M16/0666 ,  A61M16/1055 ,  A61M16/107 ,  A61M2202/30

摘要： The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.

摘要翻译： 本发明提供了一种选择用于递送疫苗的喷雾器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm（ii ）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许例如以前可商购的喷雾器 用于药物输送，用于疫苗递送。 这大大降低了识别合适的喷雾器所需的工作。 通过本发明的方法识别的喷雾器也被要求保护。

公开(公告)号：US20140107182A1

公开(公告)日：2014-04-17

申请号：US14081295

申请日：2013-11-15

申请人： Kevin Kelnar ,  David Brown

发明人： Kevin Kelnar ,  David Brown

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  C12N2310/141 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/3521

摘要： Embodiments concern methods and compositions involving miR-34 mimics, including miR-34a and miR-34c mimics. In some embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34a sequence and a complementary passenger strand. In additional embodiments, there are double-stranded RNA molecules with modified nucleotides having an active strand with a miR-34c sequence and a complementary passenger strand.

摘要翻译： 实施方案涉及涉及miR-34模拟物的方法和组合物，包括miR-34a和miR-34c模拟物。 在一些实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有miR-34a序列和补体乘客链的活性链。 在另外的实施方案中，存在具有经修饰的核苷酸的双链RNA分子，其具有与miR-34c序列和补体乘客链的活性链。

公开(公告)号：US08683560B1

公开(公告)日：2014-03-25

申请号：US12981231

申请日：2010-12-29

申请人： Marc J. Brooker ,  Mark Joseph Cavage ,  David Brown ,  Kevin Ross O'Neill ,  Eric Jason Brandwine ,  Christopher Richard Jacques de Kadt

发明人： Marc J. Brooker ,  Mark Joseph Cavage ,  David Brown ,  Kevin Ross O'Neill ,  Eric Jason Brandwine ,  Christopher Richard Jacques de Kadt

IPC分类号： G06F7/04 ,  H04L29/06 ,  H04L9/32

CPC分类号： H04L63/08 ,  G06F21/44 ,  H04L9/3247 ,  H04L63/10 ,  H04L63/20

摘要： Systems and methods for managing credentials distribute the credentials to subsets of a set of collectively managed computing resources. The collectively managed computing resources may include one or more virtual machine instances. The credentials distributed to the computing resources may be used by the computing resources to perform one or more actions. Actions may include performing one or more functions in connection with configuration, management, and/or operation of the one or more resources, and/or access of other computing resources. The ability to use credentials may be changed based at least in part on the occurrence of one or more events.

摘要翻译： 用于管理凭据的系统和方法将凭证分发到一组共同管理的计算资源的子集。 共同管理的计算资源可以包括一个或多个虚拟机实例。 分配给计算资源的证书可以被计算资源用于执行一个或多个动作。 操作可以包括执行与一个或多个资源的配置，管理和/或操作有关的一个或多个功能，和/或其他计算资源的访问。 至少部分地基于一个或多个事件的发生来改变使用凭证的能力。

公开(公告)号：US08625766B2

公开(公告)日：2014-01-07

申请号：US11452118

申请日：2006-06-12

申请人： David Brown ,  Ajit B. Pendse ,  Michael James Ward

发明人： David Brown ,  Ajit B. Pendse ,  Michael James Ward

IPC分类号： H04M3/42 ,  H04M3/493 ,  H04W24/00

CPC分类号： H04M3/42374 ,  H04M2203/2066

摘要： Methods and apparatuses for detecting current presence and/or determining capabilities of subscribers, and enabling users of communication devices to initiate communication sessions with other communication devices of selected ones of the subscribers, in selected manners, based at least in part on current presence and/or capabilities of the other subscribers, are described herein. In various embodiments, the initiating is performed without or substantially without further input from an initiating user on the other communication device.

摘要翻译： 用于检测用户的当前存在和/或确定用户能力的方法和装置，以及使得通信设备的用户能够以选定的方式发起与所选用户的其他通信设备的通信会话，至少部分地基于当前存在和/ 或其他用户的能力。 在各种实施例中，在另一个通信设备上没有或基本上没有来自发起用户的进一步输入来执行发起。

公开(公告)号：US08568971B2

公开(公告)日：2013-10-29

申请号：US12890398

申请日：2010-09-24

申请人： David Brown ,  Rick Conrad ,  Eric Devroe ,  Marianna Goldrick ,  Kerri Keiger ,  Emmanuel Labourier ,  Ivonne Moon ,  Patricia Powers ,  Jeffrey Shelton ,  Jaclyn Shingara

发明人： David Brown ,  Rick Conrad ,  Eric Devroe ,  Marianna Goldrick ,  Kerri Keiger ,  Emmanuel Labourier ,  Ivonne Moon ,  Patricia Powers ,  Jeffrey Shelton ,  Jaclyn Shingara

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6806 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/3517 ,  C12N2310/3519 ,  C12N2320/10 ,  C12P19/34 ,  C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Q2565/501 ,  C12Q2525/207

摘要： The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.

摘要翻译： 本发明涉及用于分离，富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外，本发明涉及用于产生miRNA谱并用于治疗，诊断和预后应用的这种分布的方法和组合物。

公开(公告)号：US08442097B2

公开(公告)日：2013-05-14

申请号：US12769260

申请日：2010-04-28

申请人： Patrick C. Fenton ,  Ian Williamson ,  David Brown

发明人： Patrick C. Fenton ,  Ian Williamson ,  David Brown

IPC分类号： H04B1/00

CPC分类号： H04B1/7085 ,  G01S19/21 ,  G01S19/22 ,  G01S19/30 ,  H04B1/7075 ,  H04B2201/70715

摘要： A receiver includes a pre-correlation filter that forms an image of the average chip shape of a received signal over a specified period of time. The filter includes an array of complex accumulation registers that accumulate measurements that are associated with signal samples from specific ranges of locations, or code chip phase angles, along a spread-spectrum chip. Using the accumulated measurements, the receiver estimates the location of the chip transitions in a direct path signal component. The receiver may thereafter change the starting points, sizes and numbers of ranges, such that the accumulation registers accumulate more detail from the chip edges. The receiver in addition may use the accumulated measurements from selected registers and/or selected groups of registers, to produce the correlation values that are needed to perform one or more correlation techniques and/or one or more multipath mitigation techniques. As appropriate, the sizes and/or starting points of the bins, and/or the selections of the bins for the various groupings may be altered, to change the spacings, locations, and so forth to which correlation values correspond.

摘要翻译： 接收机包括预定相关滤波器，其在指定时间段内形成接收信号的平均码片形状的图像。 该滤波器包括一组复数累积寄存器，其累积与沿着扩频芯片的特定位置范围或码片相位角的信号样本相关联的测量。 使用累积测量，接收机估计直接路径信号分量中芯片转换的位置。 接收器此后可以改变起始点，大小和范围的数量，使得累加寄存器从码片边缘积累更多的细节。 接收机另外可以使用来自所选择的寄存器和/或所选择的寄存器组的累积测量值来产生执行一个或多个相关技术和/或一个或多个多径抑制技术所需的相关值。 适当地，可以改变箱的尺寸和/或起点，和/或用于各种组的箱的选择，以改变相关值对应的间隔，位置等。