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公开(公告)号：US20050170467A1
公开(公告)日：2005-08-04
申请号：US11050559
申请日：2005-02-02
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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92.发明申请公开(公告)号：US20050153396A1
公开(公告)日：2005-07-14
申请号：US10955952
申请日：2004-09-29
申请人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
发明人： Kevin Baker , Maureen Beresini , Laura DeForge , Luc Desnoyers , Ellen Filvaroff , Wei-Qiang Gao , Mary Gerritsen , Audrey Goddard , Paul Godowski , Austin Gurney , Steven Sherwood , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , William Wood , Zemin Zhang
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K17/00 , C12N5/06 , C12N9/00 , C12N9/02 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention used to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含用于异源多肽序列的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体和本发明的多肽的制备方法 发明。
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公开(公告)号：US20050037458A1
公开(公告)日：2005-02-17
申请号：US10805667
申请日：2004-07-23
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
CPC分类号： C07K14/47 , G01N33/6872
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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94.发明申请Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders 审中-公开成纤维细胞生长因子-19（FGF-19）核酸和多肽以及用于治疗肥胖和相关疾病的方法公开(公告)号：US20050026243A1
公开(公告)日：2005-02-03
申请号：US10336979
申请日：2003-01-02
CPC分类号： C07K14/50 , A61K38/00 , C07K16/22 , C07K2317/24 , C07K2319/00 , G01N2333/50
摘要： The present invention is directed to novel polypeptides belonging to the fibroblast growth factor family and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating obesity are provided.
摘要翻译： 本发明涉及属于成纤维细胞生长因子家族的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 此外，提供了治疗肥胖症的方法。
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公开(公告)号：US06413770B1
公开(公告)日：2002-07-02
申请号：US09136801
申请日：1998-08-19
申请人： Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
发明人： Paul Godowski , Austin Gurney , Kenneth J. Hillan , David Botstein , Audrey Goddard , Margaret Roy , Napoleone Ferrara , Daniel Tumas , Ralph Schwall
IPC分类号： C07K14475
CPC分类号： C07K14/515 , A61K38/00 , C07K2319/00 , G01N2800/32 , Y10S977/773 , Y10S977/788 , Y10S977/915
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligands NL1, NL5, NL8, and NL4, the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体NL1，NL5，NL8和NL4的分离的核酸分子，由这些核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US6136569A
公开(公告)日：2000-10-24
申请号：US815520
申请日：1997-02-27
申请人： Kevin Baker , Austin Gurney
发明人： Kevin Baker , Austin Gurney
CPC分类号： C40B40/02 , C12N15/1037
摘要： The present invention relates to a novel method of identifying cDNA's which encode secreted and membrane-bound proteins. The present invention also relates to a novel method for preparing cDNA libraries enriched for signal sequences. The methods of the invention provide for an improved signal sequence detection system which results, when compared to the prior art, in a greater number of correctly identified signal sequences and less total time required to complete the procedure.
摘要翻译： 本发明涉及鉴定编码分泌蛋白和膜结合蛋白的cDNA的新方法。 本发明还涉及一种制备富集信号序列的cDNA文库的新方法。 本发明的方法提供了一种改进的信号序列检测系统，其与现有技术相比，在更多数量的正确识别的信号序列和较少的完成该过程所需的总时间中得到。
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97.发明授权Methods of using antibodies that bind the glutamate ligand binding region of Notch1 有权使用结合Notch1的谷氨酸配体结合区域的抗体的方法公开(公告)号：US08460661B2
公开(公告)日：2013-06-11
申请号：US13308224
申请日：2011-11-30
申请人： Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
发明人： Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
IPC分类号： A61K39/395 , A61P35/00 , C07K14/705 , C07K16/28 , C07K16/30
CPC分类号： C07K16/2863 , A61K31/337 , A61K39/39533 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/12 , Y10S530/809 , A61K2300/00
摘要： Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
摘要翻译： 描述了特异性结合人Notch受体的细胞外保守配体结合区域并抑制肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，该方法包括以有效抑制肿瘤生长的量施用抗Notch抗体。
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公开(公告)号：US08088617B2
公开(公告)日：2012-01-03
申请号：US12010421
申请日：2008-01-24
申请人： Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
发明人： Austin Gurney , Aaron Sato , Maureen Fitch-Bruhns
IPC分类号： C07K14/705 , C07K16/28 , C12P21/00 , C12P21/08 , C12N5/07
CPC分类号： C07K16/2863 , A61K31/337 , A61K39/39533 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/12 , Y10S530/809 , A61K2300/00
摘要： Isolated antibodies that specifically binds to an extracellular conserved ligand binding region of a human Notch receptor and inhibits growth of a tumor are described. Also described are methods of treating cancer, the method comprising administering an anti-Notch antibody in an amount effective to inhibit tumor growth.
摘要翻译： 描述了特异性结合人Notch受体的细胞外保守配体结合区域并抑制肿瘤生长的分离的抗体。 还描述了治疗癌症的方法，该方法包括以有效抑制肿瘤生长的量施用抗Notch抗体。
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公开(公告)号：US20100273257A1
公开(公告)日：2010-10-28
申请号：US12321115
申请日：2009-01-15
申请人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
发明人： Avi J. Ashkenazi , Kevin P. Baker , Anan Chuntharapai , Austin Gurney , Kyung Jin Kim , William I. Wood
IPC分类号： C12N5/10 , C07K14/00 , C07K16/18 , C12N5/16 , C07H21/04 , C12N15/63 , C12N1/19 , C12N1/21 , C12N5/071
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/4747 , C07K14/70578 , C07K16/2878 , C07K2319/00 , G01N33/57484 , G01N33/68
摘要： Novel polypeptides, designated Apo-2DcR, which are capable of binding Apo-2 ligand are provided. Compositions including Apo-2DcR chimeras, nucleic acid encoding Apo-2DcR, and antibodies to Apo-2DcR are also provided.
摘要翻译： 提供了能够结合Apo-2配体的新型多肽，称为Apo-2DcR。 还提供了包含Apo-2DcR嵌合体，编码Apo-2DcR的核酸和Apo-2DcR抗体的组合物。
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公开(公告)号：US20090291097A1
公开(公告)日：2009-11-26
申请号：US11802794
申请日：2007-05-25
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC分类号： A61K39/395 , C07K16/18 , A61P37/00
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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