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    Mass Spectrometer
    91.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20110215239A1

    公开(公告)日：2011-09-08

    申请号：US13126455

    申请日：2008-10-30

    申请人： Shinichi Yamaguchi

    发明人： Shinichi Yamaguchi

    IPC分类号： H01J49/40

    CPC分类号： H01J49/408

    摘要： Ions originating from sample components are made to fly along a loop orbit (P) multiple times, and are deviated from the loop orbit (P) when a predetermined period of time has elapsed after the ejection of the ions. A time-of-flight spectrum recording unit (81) creates a time-of-flight spectrum based on the detected signal. If an overtaking of ions occurs on the loop orbit (P), the number of turns of peaks (ions) appearing on the spectrum cannot be determined. Given this factor, an isotopic peak detector (82) finds an isotopic peak group based on the time intervals and intensity ratio of a plurality of peaks appearing on the spectrum. A flight distance computation unit 83 uses the fact that the mass difference between adjacent peaks belonging to an isotopic peak group is 1 Da when ions are singly-charged, and computes the flight distance based on a predetermined formula. From the flight distance, a mass computation unit (84) computes the number of turns, and recomputes the flight distance which is structurally determined from this number of turns. Then, the mass computation unit (84) computes the mass of the target component. This enables an acquisition of the accurate mass free of the influence of an overtaking of ions and other factors.

    摘要翻译： 来自样品成分的离子使得在离子排出后经过规定时间后，多次沿着环轨道（P）飞行，并且偏离环轨道（P）。 飞行时间谱记录单元（81）基于检测到的信号产生飞行时间谱。 如果在环路轨道（P）上发生离子超驰，则无法确定出现在频谱上的峰值（离子）的匝数。 考虑到这个因素，同位素峰值检测器（82）基于频谱上出现的多个峰值的时间间隔和强度比找到同位素峰值组。 飞行距离计算单元83使用以下事实：当离子单独充电时属于同位素峰组的相邻峰之间的质量差为1Da，并且基于预定公式计算飞行距离。 从飞行距离，质量计算单元（84）计算匝数，并且重新计算从该匝数结构确定的飞行距离。 然后，质量计算单元（84）计算目标分量的质量。 这使得能够获得没有超过离子和其他因素的影响的精确质量。

    Mass Spectrometer
    93.
    发明申请
    Mass Spectrometer 有权
    质谱仪

    公开(公告)号：US20110180705A1

    公开(公告)日：2011-07-28

    申请号：US13122718

    申请日：2008-10-09

    申请人： Shinichi Yamaguchi

    发明人： Shinichi Yamaguchi

    IPC分类号： H01J49/40

    CPC分类号： H01J49/408

    摘要： A basic ion optical system having a guaranteed capability for the temporal focusing of ions, including sector-shaped electrodes, an injection slit and an ejection slit, is arranged on the same plane. Four or more sets of the basic ion optical systems are arrayed at predetermined intervals in a direction substantially orthogonal to the aforementioned plane. The injection slit on a topmost basic ion optical system plane and the ejection slit on a basic ion optical system plane located immediate below, as well as the injection slit on a bottommost basic ion optical system plane and the ejection slit on a basic ion optical system plane located immediate above, are respectively connected by another type of basic ion optical system having a guaranteed capability for the temporal focusing of ions. The other injection slits and ejection slits are respectively connected by another type of basic ion optical system having a guaranteed capability for the temporal focusing of ions. Thus, a loop orbit having a three-dimensionally deformed figure “8”-shape is formed, whereby the flight distance is elongated while ensuring the temporal focusing of the ions for the entire system, simultaneously with utilizing the three-dimensional space to compactify the ion optical system.

    摘要翻译： 具有对离子的时间聚焦的保证能力的基本离子光学系统，包括扇形电极，注入狭缝和喷射狭缝，布置在同一平面上。 四组以上的基本离子光学系统在与上述平面大致正交的方向上以规定间隔排列。 在最上面的基本离子光学系统平面上的注入狭缝和位于紧邻下面的基本离子光学系统平面上的喷射狭缝以及最底层的基本离子光学系统平面上的注入狭缝和基本离子光学系统上的喷射狭缝 位于紧邻上方的平面分别由具有用于离子的时间聚焦的有保证的能力的另一类型的基本离子光学系统分别连接。 其他注入狭缝和喷射狭缝分别通过具有用于离子的时间聚焦的有保证的能力的另一类型的碱性离子光学系统连接。 因此，形成具有三维变形的图形“8”形状的环形轨道，由此飞行距离是细长的，同时确保用于整个系统的离子的时间聚焦，同时利用三维空间来压缩 离子光学系统。

    Mass spectrometer
    94.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07928372B2

    公开(公告)日：2011-04-19

    申请号：US12016522

    申请日：2008-01-18

    申请人： Shinichi Yamaguchi ,  Masaru Nishiguchi ,  Kiyoshi Ogawa ,  Yoshihiro Ueno

    发明人： Shinichi Yamaguchi ,  Masaru Nishiguchi ,  Kiyoshi Ogawa ,  Yoshihiro Ueno

    IPC分类号： B01D59/44

    CPC分类号： H01J49/38 ,  H01J49/408

    摘要： A mass spectrometer is provided in which ions are favorably introduced into a loop orbit or favorably led out from the loop orbit without affecting the motion of the ions flying along the loop orbit. An ion-introduction orbit 5 is set to correspond to the orbit (ejection orbit portion 4) of ions after being bent by the sector-shaped electric field E1 in the loop orbit 4. When ions are introduced, a voltage applied to the electrode unit 11 is put to zero to release the sector-shaped electric field E1. Then the ions emitted along the ion-introduction orbit 5 fly straight in the electrode unit 11. The direction and position of the ions coming out from the exit end of the electric field is the same as those ions flying along the loop orbit 4. Therefore, there is no need for placing a deflection electrode for introducing/leading-out ions on the loop orbit.

    摘要翻译： 提供质谱仪，其中离子有利地被引入环轨道或有利地从环轨道引出，而不影响沿着环路轨道飞行的离子的运动。 离子引入轨道5被设置为对应于在环路轨道4中的扇形电场E1弯曲之后的离子的轨道（喷射轨道部分4）。当离子被引入时，施加到电极单元的电压 11被置零以释放扇形电场E1。 然后沿离子引入轨道5发射的离子在电极单元11中直线飞行。从电场出射端出来的离子的方向和位置与沿着环轨道4飞行的那些离子相同。因此 ，不需要在环轨道上放置用于引入/引出离子的偏转电极。

    Mass spectrometer
    96.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07763847B2

    公开(公告)日：2010-07-27

    申请号：US11781072

    申请日：2007-07-20

    申请人： Masaru Nishiguchi ,  Shinichi Yamaguchi ,  Michisato Toyoda

    发明人： Masaru Nishiguchi ,  Shinichi Yamaguchi ,  Michisato Toyoda

    IPC分类号： H01J49/06

    CPC分类号： H01J49/408

    摘要： An ion optical system to form a loop orbit is provided to sufficiently ensure required performance such as ion transmission efficiency while making it easy to design the system by alleviating a space-focusing condition. The loop orbit of the ion optical system is realized so as to satisfy (t|x)=(t|α)=(t|δ)=0 as the time-focusing condition and to satisfy −2

    摘要翻译： 提供形成环轨道的离子光学系统，以充分确保所需的性能，例如离子传输效率，同时通过减轻空间聚焦条件容易地设计系统。 实现离子光学系统的环路轨迹，以满足（t | x）=（t |α）=（t |δ）= 0作为时间聚焦条件，并满足-2 <（x | x） +（α|α）<2和-2 <（y | y）+（＆bgr; |＆bgr））<2作为空间聚焦条件。 （x | x）和其他类似术语是由离子光学系统的通用表达式格式由括号中指示的元素确定的常数。 与（x | x），（α|α），（y | y）和（＆bgr | | bgr）中的每一个需要为±1的常规空间聚焦条件相反，条件基本上减轻。 因此，决定离子光学系统配置的电极形状的参数具有更高的自由度。

    DATA PROCESSOR FOR MASS SPECTROMETER
    98.
    发明申请
    DATA PROCESSOR FOR MASS SPECTROMETER 有权
    数据处理器用于大量光谱仪

    公开(公告)号：US20090230298A1

    公开(公告)日：2009-09-17

    申请号：US12301306

    申请日：2006-05-18

    申请人： Shinichi Yamaguchi

    发明人： Shinichi Yamaguchi

    IPC分类号： H01J49/00

    CPC分类号： G01N27/62

    摘要： A main peak list is created with the data obtained by an MSn analysis (S1), the difference between the mass-to-charge ratio of each product ion listed on this main peak list and that of the precursor ion is calculated (S2), and an auxiliary peak list for forming a virtual peak corresponding to the mass-to-charge ratio difference is created (S3). On the same graph, an MSn spectrum data is created so that each peak listed on the main peak list and each peak listed on the auxiliary peak list are drawn with different display colors (S4), and the MSn spectrum is displayed on the display screen (S5). Consequently, an MSn analysis result for a plurality of precursor ions with different mass-to-charge ratios becomes easy to be compared. In particular, it is possible to easily and visually determine whether or not a fragment having the same mass-to-charge ratio desorbed by a dissociation exists.

    摘要翻译： 利用MSn分析获得的数据（S1）创建主峰列表，计算出在该主峰列表上列出的各产物离子的质荷比与前体离子的质荷比之差（S2） 并且创建用于形成与质荷比差相对应的虚拟峰的辅助峰列表（S3）。 在同一曲线图上，创建MSn频谱数据，使得主峰列表上列出的每个峰和辅助峰列表上列出的每个峰以不同的显示颜色绘制（S4），并且MSn频谱显示在显示屏幕上 （S5）。 因此，容易比较具有不同质荷比的多个前体离子的MSn分析结果。 特别地，可以容易地和目测地确定是否存在具有通过解离解吸的相同质荷比的片段。

    Method of analyzing mass analysis data and apparatus for the method
    99.
    发明授权
    Method of analyzing mass analysis data and apparatus for the method 有权
    分析方法的质量分析数据和设备

    公开(公告)号：US07529630B2

    公开(公告)日：2009-05-05

    申请号：US11730983

    申请日：2007-04-05

    申请人： Shinichi Yamaguchi ,  Yusuke Inohana

    发明人： Shinichi Yamaguchi ,  Yusuke Inohana

    IPC分类号： C12Q1/04

    CPC分类号： H01J49/0036 ,  G06F19/703

    摘要： The present invention provides a method and an apparatus for analyzing mass analysis data for selecting a component similar to a target component quickly and accurately, based on MSn analysis for each unknown component in the sample. First, MSn analysis is performed for each of the components in the mixed sample, and based on the obtained spectral data (measured data) and the spectral data of the target component (reference data), predetermined parameters are extracted (Step S11 to S13). Next, by multivariable analysis of the parameters, the similarity between the target component and each of the components in the mixed sample is evaluated (Step S14). Finally, based on the similarity value, components similar to the target component are selected (Step S16).

    摘要翻译： 本发明提供了一种用于分析质量分析数据的方法和装置，用于基于样本中的每个未知分量的MSn分析，快速准确地选择与目标分量相似的分量。 首先，对混合样本中的每个分量执行MSn分析，并且基于获得的光谱数据（测量数据）和目标分量（参考数据）的光谱数据，提取预定参数（步骤S11至S13） 。 接下来，通过参数的多变量分析，评价混合样本中的目标成分与各成分的相似度（步骤S14）。 最后，基于相似度值，选择与目标成分相似的成分（步骤S16）。

    Mass spectrometer
    100.
    发明授权
    Mass spectrometer 有权
    质谱仪

    公开(公告)号：US07514675B2

    公开(公告)日：2009-04-07

    申请号：US11730621

    申请日：2007-04-03

    申请人： Shinichi Yamaguchi

    发明人： Shinichi Yamaguchi

    IPC分类号： H01J49/40

    CPC分类号： H01J49/004 ,  H01J49/027 ,  H01J49/408

    摘要： The present invention provides a single set of mass spectrometer capable of selectively performing the following two modes of analyses according to the purpose of analysis: the first mass spectrometry mode in which the analysis can be repeated at short intervals of time; and the second mass spectrometry mode in which the analysis can be performed with high mass resolution and high accuracy. In an embodiment of the present invention, ions ejected from an ion source 1 travel along a straight path B, on which gate electrodes 3 are provided. When a voltage is applied from an MS mode selection controller 7 to the gate electrodes 3, the ions are introduced into a loop orbit A. Located on the loop orbit A is a second ion detector 6, which is a nondestructive type of ion detector. Detection signals of the second ion detector 6 are sent to a data processor 9, which extracts flight time spectrum data from those signals and Fourier-transforms those data to convert the time axis to a frequency axis. From the frequency spectrum thus created, the mass-to-charge ratio of each ion is calculated with high accuracy. When no voltage is applied to the gate electrodes 3, the ions ejected from the ion source 1 travel along the straight path B and arrive at a first ion detector 5. This mode of analysis requires only a short period of time and can achieve a high level of time resolution.

    摘要翻译： 本发明提供了一组能够根据分析目的选择性地执行以下两种分析模式的质谱仪：第一种质谱模式，其中可以在短时间间隔内重复分析; 以及可以以高质量分辨率和高精度进行分析的第二质谱模式。 在本发明的一个实施例中，从离子源1喷出的离子沿着设置有栅电极3的直线路径B行进。 当从MS模式选择控制器7将电压施加到栅极电极3时，离子被引入环路轨道A.位于环路轨道A上的是第二离子检测器6，其是非破坏性的离子检测器。 第二离子检测器6的检测信号被发送到数据处理器9，数据处理器9从这些信号中提取飞行时间频谱数据，并对这些数据进行傅立叶变换，以将时间轴转换为频率轴。 根据这样产生的频谱，以高精度计算各离子的质荷比。 当没有电压施加到栅电极3时，从离子源1喷出的离子沿着直线路径B行进并到达第一离子检测器5.这种分析方式仅需要很短的时间并且可以达到高 时间分辨率。