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    Alleles of the OpcA gene from coryneform bacteria
    91.
    发明授权
    Alleles of the OpcA gene from coryneform bacteria 有权
    来自棒状细菌的OpcA基因的等位基因

    公开(公告)号：US07700313B2

    公开(公告)日：2010-04-20

    申请号：US11383253

    申请日：2006-05-15

    申请人： Natalie Schischka ,  Brigitte Bathe ,  Georg Thierbach

    发明人： Natalie Schischka ,  Brigitte Bathe ,  Georg Thierbach

    IPC分类号： C12P1/00 ,  C12P13/04

    CPC分类号： C12P13/08 ,  C12N9/0006 ,  C12P13/227

    摘要： The invention relates to mutants and alleles of the opcA gene of coryneform bacteria, which encode variants of the OpcA subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by using bacteria which harbor said alleles.

    摘要翻译： 本发明涉及编码葡萄糖-6-磷酸脱氢酶（EC：1.1.1.49）的OpcA亚基变体的棒状杆菌细菌的opcA基因的突变体和等位基因，以及制备氨基酸，特别是L-赖氨酸和 L-色氨酸通过使用含有所述等位基因的细菌。

    Process for the preparation of l-amino acids
    92.
    发明授权
    Process for the preparation of l-amino acids 失效
    制备1-氨基酸的方法

    公开(公告)号：US07262036B2

    公开(公告)日：2007-08-28

    申请号：US11419529

    申请日：2006-05-22

    申请人： Bettina Hädrich ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    发明人： Bettina Hädrich ,  Walter Pfefferle ,  Achim Marx ,  Jörn Kalinowski ,  Brigitte Bathe ,  Alfred Pühler

    IPC分类号： C12P13/08 ,  C12N1/20 ,  C12N15/00 ,  C07K1/00 ,  C07H21/02

    CPC分类号： C07K14/34 ,  C12N9/00 ,  C12P13/08

    摘要： Disclosed herein is an isolated polynucleotide comprising a polynucleotide sequence chosen from the group consisting of a) polynucleotide which is identical to the extent of at least 70% to a polynucleotide which codes for a polypeptide which comprises the amino acid sequence of SEQ ID NO:2, b) polynucleotide which codes for a polypeptide which comprises an amino acid sequence which is identical to the extent of at least 70% to the amino acid sequence of SEQ ID NO:2 c) polynucleotide which is complementary to the polynucleotides of a) and b) and d) polynucleotide comprising at least 15 successive nucleotides of the polynucleotide sequence of a), b) or c), and processes for the fermentative preparation of L-amino acid with amplification of the zwa1 gene in the coryneform bacteria employed.

    摘要翻译： 本文公开了一种分离的多核苷酸，其包含选自以下的多核苷酸序列：a）与编码包含SEQ ID NO：2的氨基酸序列的多肽的多核苷酸的程度相同的多核苷酸 b）编码多肽的多核苷酸，其包含与SEQ ID NO：2的氨基酸序列至少70％相同程度的氨基酸序列c）与a）和 b）和d）包含a），b）或c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及在所用棒状细菌中扩增zwa1基因的L-氨基酸的发酵制剂的方法。

    Coryneform Bacteria Which Produce Chemical Compounds I
    93.
    发明申请
    Coryneform Bacteria Which Produce Chemical Compounds I 审中-公开
    生产化学化合物的棒状细菌I

    公开(公告)号：US20070111291A1

    公开(公告)日：2007-05-17

    申请号：US11612208

    申请日：2006-12-18

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    IPC分类号： C12P13/24 ,  C12P13/22 ,  C12P13/04 ,  C12P13/20 ,  C12P13/14 ,  C12P13/08 ,  C12N15/74 ,  C12N1/21

    CPC分类号： C12R1/15 ,  C12N15/52 ,  C12P13/08

    摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

    摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。

    Coryneform bacteria which produce chemical compounds I
    94.
    发明授权
    Coryneform bacteria which produce chemical compounds I 有权
    产生化学化合物I的棒状细菌

    公开(公告)号：US07160711B2

    公开(公告)日：2007-01-09

    申请号：US10358405

    申请日：2003-02-05

    申请人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    发明人： Brigitte Bathe ,  Caroline Kreutzer ,  Bettina Mockel ,  Georg Thierbach

    IPC分类号： C12N1/12 ,  C12N15/00

    CPC分类号： C12R1/15 ,  C12N15/52 ,  C12P13/08

    摘要： The invention relates to coryneform bacteria which have, in addition to at least one copy, present at the natural site (locus), of an open reading frame (ORF), gene or allele which codes for the synthesis of a protein or an RNA, in each case a second, optionally third or fourth copy of this open reading frame (ORF), gene or allele at in each case a second, optionally third or fourth site in a form integrated into the chromosome and processes for the preparation of chemical compounds by fermentation of these bacteria.

    摘要翻译： 本发明涉及除了至少一个拷贝存在于编码合成蛋白质或RNA的开放阅读框（ORF），基因或等位基因的天然位点（基因座）外的棒状细菌， 在每种情况下，该开放阅读框（ORF）的第二个，任选的第三或第四个拷贝，基因或等位基因在每种情况下都是整合到染色体中的形式的第二个，任选的第三或第四个位点，并且用于制备化合物 通过这些细菌的发酵。

    Nucleotide sequences coding for the pknD gene
    97.
    发明申请
    Nucleotide sequences coding for the pknD gene 有权
    编码pknD基因的核苷酸序列

    公开(公告)号：US20050255566A1

    公开(公告)日：2005-11-17

    申请号：US11110837

    申请日：2005-04-21

    申请人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

    发明人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

    IPC分类号： C12N9/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N1/21 ,  C12N15/74 ,  C12P13/04

    CPC分类号： C12N9/1205 ,  C12R1/15

    摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.

    摘要翻译： 一种分离的多核苷酸，其含有选自以下的多核苷酸序列：（a）与编码含有SEQ ID No.2的氨基酸序列的多肽的多核苷酸至少70％的多核苷酸，（b） 编码含有与SEQ ID No.2的氨基酸序列至少70％相同的氨基酸序列的多肽，（c）与（a）或（b）的多核苷酸互补的多核苷酸和（ d）包含（a），（b）或（c）的多核苷酸序列的至少15个连续核苷酸的多核苷酸，以及使用棒状杆菌制备L-氨基酸的发酵方法，其中至少pknD基因是 扩增和使用含有本发明序列的多核苷酸作为杂交探针。

    Nucleotide sequences coding for the pknD gene
    99.
    发明授权
    Nucleotide sequences coding for the pknD gene 失效

    公开(公告)号：US06927052B2

    公开(公告)日：2005-08-09

    申请号：US09949971

    申请日：2001-09-12

    申请人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

    发明人： Brigitte Bathe ,  Indra Schroeder ,  Mike Farwick ,  Thomas Hermann

    IPC分类号： C12N9/12 ,  C12N9/00 ,  C07H21/04 ,  C12N1/20 ,  C12N9/10 ,  C12N15/00

    CPC分类号： C12N9/1205 ,  C12R1/15

    摘要： An isolated polynucleotide which contains a polynucleotide sequence selected from the group comprising: (a) a polynucleotide which is at least 70% identical to a polynucleotide coding for a polypeptide containing the amino acid sequence of SEQ ID No. 2, (b) a polynucleotide coding for a polypeptide containing an amino acid sequence which is at least 70% identical to the amino acid sequence of SEQ ID No. 2, (c) a polynucleotide which is complementary to the polynucleotides of (a) or (b), and (d) a polynucleotide containing at least 15 consecutive nucleotides of the polynucleotide sequence of (a), (b), or (c), and a fermentation process for the preparation of L-amino acids using corynebacteria in which at least the pknD gene is amplified, and to the use, as hybridization probes, of polynucleotides containing the sequences according to the invention.