公开(公告)号：US6143438A

公开(公告)日：2000-11-07

申请号：US28732

申请日：1998-02-24

Applicant: Matthias Geibl ,  Thomas J. Dougherty ,  Gerald D. Slayton ,  Mark S. Inkmann ,  Guy L. Pfeifer

Inventor： Matthias Geibl ,  Thomas J. Dougherty ,  Gerald D. Slayton ,  Mark S. Inkmann ,  Guy L. Pfeifer

IPC: H01M2/12 ,  H01M2/36 ,  H01M10/06 ,  H01M10/42

CPC classification number: H01M2/1217 ,  H01M10/06 ,  H01M10/42 ,  H01M2/1205 ,  H01M2/36

Abstract: An improved vent cap system for use in an electrochemical battery is provided which includes a ring flange for forming a ring seal between the vent cap assembly and the fill tube. When the vent cap assembly is positioned in the battery housing, the ring flange and the fill tube deform to create a seal therebetween to provide a fluid tight seal.

Abstract translation: 提供了一种用于电化学电池的改进的通气帽系统，其包括用于在通气盖组件和填充管之间形成环形密封件的环形凸缘。 当通气盖组件定位在电池壳体中时，环形凸缘和填充管变形以在其间形成密封以提供流体密封。

公开(公告)号：US5773977A

公开(公告)日：1998-06-30

申请号：US634650

申请日：1996-04-18

Applicant: Thomas J. Dougherty

Inventor： Thomas J. Dougherty

IPC: G01R31/00 ,  G01R31/36 ,  G01N27/416

CPC classification number: G01R31/362 ,  G01R31/3648 ,  G01R31/006 ,  G01R31/3631 ,  G01R31/3668

Abstract: A battery tester and associated method for determining if one or more cells in a storage battery are capable of storing sufficient charge prior to charging the battery. A predetermined load is applied to the battery for a predetermined period of time, and then the bounce back voltage of the battery is measured immediately after the load is removed. If the bounce back voltage of the battery is within a predetermined range after a predetermined time after the load is removed, then one or more cell in the battery is bad and the battery can be rejected prior to being charged.

Abstract translation: 一种电池测试器和相关联的方法，用于确定蓄电池中的一个或多个电池是否能够在对电池充电之前储存足够的电量。 在电池预定的时间内施加预定的负载，然后在卸载负载后立即测量电池的反弹电压。 如果电池的反弹电压在负载被去除之后的预定时间之后在预定范围内，则电池中的一个或多个电池坏，并且在充电之前可以拒绝电池。

公开(公告)号：US5591847A

公开(公告)日：1997-01-07

申请号：US247866

申请日：1994-05-23

Applicant: Ravindra K. Pandey ,  Thomas J. Dougherty ,  Kevin M. Smith ,  Fuu-Yau Shiau

Inventor： Ravindra K. Pandey ,  Thomas J. Dougherty ,  Kevin M. Smith ,  Fuu-Yau Shiau

IPC: A61K41/00 ,  C07D487/22 ,  C07D491/22

CPC classification number: C07D487/22 ,  A61K41/0071 ,  C07D491/22

Abstract: Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy.Such compounds have the formula: ##STR1## where Z is .dbd.O or .dbd.NR.sub.6, where R.sub.6 is lower alkyl of from 1 to 8 carbon atoms or ##STR2## R.sub.1 is ##STR3## where R.sub.7 is ##STR4## or --ORS, where R.sub.8 is hydrogen or lower alkyl of 1 to 8 carbon atoms, or R.sub.7 is an amino acid residue connected at a nitrogen atom of such residue; R.sub.2 is lower alkyl or lower alkylene of from 2 to 4 carbon atoms or a formal or carbonyl containing group of from 1 to 4 carbon atoms; R.sub.3 and R.sub.4 are --H or --OR.sub.8 or are joined together so that each represents one-half of a chemical bond and R.sub.4 may be taken together with R.sub.5 to form .dbd.O; and R.sub.5 is ethyl or is taken together with R.sub.4 to form .dbd.O; provided that when Z is --O-- the sum of the number of carbon atoms in R.sub.1 through R.sub.5 is from 12 to 20 and when Z is .dbd.NR.sub.6, the sum of the number of carbon atoms in R.sub.1 through R.sub.6 is 8 to 20.

Abstract translation: 具有作为光吸收化合物用途的化合物，特别是在光动力疗法领域。 这样的化合物具有下式：其中Z是=或NR 6，其中R 6是1至8个碳原子的低级烷基或者其中R 7是<或>，或者-OR，其中 R8是氢或1〜8个碳原子的低级烷基，或R7是在这种残基的氮原子上连接的氨基酸残基; R 2是2至4个碳原子的低级烷基或低级亚烷基或含有1至4个碳原子的形式或含羰基的基团; R 3和R 4是-H或-OR 8或连接在一起，使得各自表示化学键的一半，并且R 4可以与R 5一起形成= O; 并且R 5是乙基或与R 4一起形成= O; 条件是当Z为-O-时，R 1至R 5中的碳原子数之和为12至20，当Z为NR 6时，R 1至R 6中的碳原子数之和为8至20。

公开(公告)号：US5543248A

公开(公告)日：1996-08-06

申请号：US390682

申请日：1995-02-17

Applicant: Thomas J. Dougherty ,  Mark S. Inkmann ,  Debra L. Smith ,  Michael T. Reher

Inventor： Thomas J. Dougherty ,  Mark S. Inkmann ,  Debra L. Smith ,  Michael T. Reher

IPC: H01M2/02 ,  H01M2/10 ,  H01M10/50 ,  H01M2/00

CPC classification number: H01M2/1072 ,  H01M10/613 ,  H01M10/625 ,  H01M10/6562 ,  H01M10/6563 ,  H01M10/658

Abstract: A battery shield for a storage battery includes first and second members which are dimensioned to fit around the battery, forming a shield structure, that is open at its top and encloses the battery on all four sides and on the bottom, forming a heat shield for protecting the battery from hot temperatures, the first and second members being hinged to a common base and are adapted to be pivoted about respective hinges outwardly away from another to an open position to facilitate installation of a battery in the shield and to then be moved upwardly and toward one another, in the manner of a "clamshell", to a closed position for enclosing the battery within the battery shield.

Abstract translation: 用于蓄电池的电池护罩包括第一和第二构件，第一和第二构件的尺寸适于围绕电池，形成屏蔽结构，该屏蔽结构在其顶部开口并且围绕所有四个侧面和底部封装电池，形成用于 保护电池免受热的温度影响，第一和第二构件被铰接到共同的基座上并且适于围绕各自的铰链向外远离另一个枢转到打开位置，以便于将电池安装在屏蔽中并且然后向上移动 并且以“蛤壳式”的方式彼此相向地将电池封闭在电池护罩内的关闭位置。

公开(公告)号：US4932934A

公开(公告)日：1990-06-12

申请号：US236603

申请日：1988-08-24

Applicant: Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

Inventor： Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

IPC: A61B5/00 ,  A61K31/40 ,  A61K41/00 ,  A61K49/00 ,  A61K51/00 ,  A61N5/06 ,  A61P35/00 ,  A61P43/00 ,  C07D487/22 ,  C07D519/00 ,  C09B47/00 ,  G02B6/04 ,  G02B6/26 ,  G02B6/42

CPC classification number: A61K31/40 ,  A61B5/411 ,  A61B5/416 ,  A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  C07D519/00 ,  G02B6/262 ,  G02B6/4204 ,  A61B5/0071 ,  A61B5/0084 ,  G02B6/4298 ,  Y10S607/901

Abstract: To obtain tumor-selective, photosensitizing drugs useful in the localization of neoplastic tissue and treatment of abnormal neoplastic tissue such as tumors, one of two methods is used. In the first method, a hydrolyzed mixture of the products of reaction of hematoporphyrin with acetic acid and sulfuric acid is cycled through a microporous membrane system to exclude low molecular weight products. In the second method, drugs are synthesized or derived from other pyrrole compounds. The drugs: (1) include two covalently bound groups, each with four rings, some of which are pyrroles such as phlorins, porphyrins, chlorins, substituted pyrroles, substituted chlorins or substituted phlorins, each group being arranged in a ring structure, connected covalently to another group and have a triplet energy state above 37.5 kilocalories per mole; (2) are soluble in water, forming an aggregate of over 10,000 molecular weight in water and have an affinity for each other compared to serum protein such that 10 to 100 percent remain self aggregated in serum protein; and (3) are lipophillic and able to disaggregate and attach to cell plasma, nuclear membrane, mitochondria, lysosomes and tissue. The drug obtained by the first method has an empirical formula of approximately C.sub.68 H.sub.70 N.sub.8 O.sub.11 or C.sub.68 H.sub.66 N.sub.8 O.sub.11 Na.sub.4. Neoplastic tissue retains the drug after it has cleared normal tissues and illumination results in necrosis. Moreover, other photosensitizing materials may be combined with a carrier that enters undesirable tissues and cells of the reticular endothelial system such as macrophages. These photosensitizing materials: (1) must have a triplet energy state above 3.5 kilocalories per mole; (2) cannot be easily oxidized; and (3) not physically quench any required energy state. Preferably, this photosensitizing material should be lipophilic.

Abstract translation: 为了获得肿瘤选择性的光敏药物，可用于肿瘤组织的定位和治疗异常肿瘤组织如肿瘤，使用两种方法之一。 在第一种方法中，血卟啉与乙酸和硫酸的反应产物的水解混合物循环通过微孔膜系统以排除低分子量产物。 在第二种方法中，合成或衍生自其他吡咯化合物的药物。 药物：（1）包括两个共价结合的基团，每个具有四个环，其中一些是吡咯，例如卟啉，卟啉，二氢卟酚，取代的吡咯，取代的二氢卟酚或取代的藜芦烯，每个组排列成环结构，共价连接 到另一组，并具有高于每摩尔37.5千卡的三线态能量状态; （2）可溶于水，与血清蛋白质相比，在水中形成了超过10,000分子量的聚集体，并且与血清蛋白质具有亲和力，使得10％至100％在血清蛋白中保持自我聚集; 和（3）是脂肪性的并且能够分解并附着于细胞血浆，核膜，线粒体，溶酶体和组织。 通过第一种方法获得的药物具有约C68H70N8O11或C68H66N8O11Na4的经验式。 肿瘤组织清除正常组织后保留药物，照明会导致坏死。 此外，其它光敏材料可以与进入网状内皮系统的不希望的组织和细胞如巨噬细胞的载体组合。 这些光敏材料：（1）必须具有每千克3.5千卡以上的三线态能量状态; （2）不易氧化; 和（3）不能物理地淬灭任何所需的能量状态。 优选地，该光敏材料应该是亲脂的。

公开(公告)号：US4889129A

公开(公告)日：1989-12-26

申请号：US243163

申请日：1988-09-08

Applicant: Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

Inventor： Thomas J. Dougherty ,  William R. Potter ,  Kenneth R. Weishaupt

IPC: A61B5/00 ,  A61K31/40 ,  A61K41/00 ,  A61K49/00 ,  A61K51/00 ,  A61N5/06 ,  A61P35/00 ,  A61P43/00 ,  C07D487/22 ,  C07D519/00 ,  C09B47/00 ,  G02B6/04 ,  G02B6/26 ,  G02B6/42

CPC classification number: A61K31/40 ,  A61B5/411 ,  A61B5/416 ,  A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  C07D519/00 ,  G02B6/262 ,  G02B6/4204 ,  A61B5/0071 ,  A61B5/0084 ,  G02B6/4298 ,  Y10S607/901

Abstract: To provide to and receive radiation from a photodynamic drug in neoplastic tissue, a laser system transmits radiation through an interface into a radiation delivery system, which is in juxtaposition with neoplastic tissue containing a photodynamic drug. The laser system may be a single argon laser pumping a dye laser, two parallel sets of argon lasers pumping a dye laser, a krypton laser or a xenon laser. In addition to transmitting radiation from the laser to the delivery system, the interface system may: (1) direct a portion of the light back to the laser's power supply to control the intensity of the radiation emitted from the laser; and/or (2) receive light from the light conductors of the delivery system. The interface channels light to radiation sensing devices which are either from a beam splitter indicating the magnitude of the radiation delivered from the laser system to the radiation delivery system or radiation leaking through the light conductor. Luminescent light from the photodynamic drug is selected and provides an indication of drug density and in some embodiments depth of the activity.

Abstract translation: 为了提供和接受来自肿瘤组织中的光动力药物的辐射，激光系统将辐射通过界面传播到放射递送系统中，辐射递送系统与包含光动力药物的肿瘤组织并置。 激光系统可以是泵浦染料激光器的单个氩激光器，两个并联的氩激光器泵浦染料激光器，氪激光器或氙激光器。 除了将激光发射到传送系统之外，接口系统可以：（1）将一部分光引导回激光器的电源以控制从激光器发射的辐射的强度; 和/或（2）从输送系统的光导体接收光。 接口通道照射到辐射感测装置，辐射传感装置来自分束器，其指示从激光系统传送到辐射传播系统的辐射的大小或通过光导体泄漏的辐射。 选择来自光动力药物的发光，并提供药物密度的指示，并且在一些实施方案中提供活动深度。

公开(公告)号：US4322685A

公开(公告)日：1982-03-30

申请号：US126165

申请日：1980-02-29

Applicant: Charles E. Frailing ,  Thomas J. Dougherty ,  Richard T. Johnson

Inventor： Charles E. Frailing ,  Thomas J. Dougherty ,  Richard T. Johnson

IPC: G01R31/36 ,  G01N27/42

CPC classification number: G01R19/16542 ,  G01R31/3651 ,  G01R31/3658 ,  G01R31/3668 ,  G01R31/3627 ,  G01R31/3631 ,  G01R31/3675 ,  G01R31/3696

Abstract: There are described apparatus for detecting the presence of a defective cell in a lead-acid storage battery. The apparatus is included as a part of a larger apparatus for analyzing the condition of the battery and its suitability for further use in automobile lighting, starting, and ignition applications. The apparatus measures the terminal potential of the battery when it is subject to a constant resistance load. If that potential is found to increase more than a predetermined amount during a time interval following the application of the load, the battery is known to have at least one defective cell.

Abstract translation: 描述了用于检测铅蓄电池中有缺陷电池的存在的装置。 该装置作为用于分析电池状况的更大装置的一部分以及其适用于汽车照明，启动和点火应用中的进一步使用。 该装置在受到恒定电阻负载时测量电池的端子电位。 如果在施加负载之后的时间间隔内发现该电位增加超过预定量，则已知电池具有至少一个有缺陷的电池。

公开(公告)号：US08874298B2

公开(公告)日：2014-10-28

申请号：US13806075

申请日：2011-06-21

Applicant: Gary P. Houchin-Miller ,  Craig W. Rigby ,  Thomas J. Dougherty ,  James S. Symanski

Inventor： Gary P. Houchin-Miller ,  Craig W. Rigby ,  Thomas J. Dougherty ,  James S. Symanski

IPC: B60L11/18 ,  B60W20/00 ,  H02J7/00

CPC classification number: B60L11/1864 ,  B60L11/1879 ,  H02J7/0013 ,  Y02T10/7005 ,  Y02T10/7055 ,  Y02T10/7061 ,  Y10S903/903

Abstract: A battery system includes a plurality of battery modules electrically coupled together in series. The battery system also includes a first electronic control unit (ECU) configured to act as a master ECU. The master ECU is electronically coupled to a first one of the plurality of battery modules. The battery system further includes a plurality of slave ECUs, wherein each slave ECU is electronically coupled to one of the other of the plurality of battery modules. The master ECU is configured to control whether electrical power is provided to each of the plurality of slave ECUs.

Abstract translation: 电池系统包括串联电耦合在一起的多个电池模块。 电池系统还包括被配置为充当主ECU的第一电子控制单元（ECU）。 主ECU电耦合到多个电池模块中的第一个。 电池系统还包括多个从属ECU，其中每个从属ECU电耦合到多个电池模块中的另一个电池模块中的一个。 主ECU被配置为控制是否向多个从ECU中的每一个提供电力。

公开(公告)号：US08609278B2

公开(公告)日：2013-12-17

申请号：US13042385

申请日：2011-03-07

Applicant: Jason D. Fuhr ,  Thomas J. Dougherty ,  John P. Dinkelman

Inventor： Jason D. Fuhr ,  Thomas J. Dougherty ,  John P. Dinkelman

IPC: H01M4/02

CPC classification number: H01M10/0585 ,  H01M2/263 ,  H01M2/266 ,  H01M10/0587

Abstract: An electrochemical cell includes a cell element comprising at least one electrode. A portion of the at least one electrode extends outward from an end of the cell element. The portion of the at least one electrode is folded onto itself to provide a coupling surface for conductive connection to a terminal of the electrochemical cell.

Abstract translation: 电化学电池包括包含至少一个电极的电池元件。 至少一个电极的一部分从电池元件的端部向外延伸。 至少一个电极的部分折叠到其自身上以提供用于与电化学电池的端子的导电连接的耦合表面。

公开(公告)号：US08133473B2

公开(公告)日：2012-03-13

申请号：US11431275

申请日：2006-05-10

Applicant: Ravindra K. Pandey ,  Zachary Grossman ,  Peter Kanter ,  Thomas J. Dougherty

Inventor： Ravindra K. Pandey ,  Zachary Grossman ,  Peter Kanter ,  Thomas J. Dougherty

IPC: A61B5/055

CPC classification number: A61K51/0485 ,  A61K41/0071 ,  A61K49/0002 ,  A61K49/085 ,  A61K49/10 ,  A61K51/0478 ,  C07D471/22 ,  C07D487/22

Abstract: A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissue. The preferred compounds have the structural formula: where R1, R2, R2a R3, R3a R4, R5, R5a R6, R7, R7a, and R8 cumulatively contain at least two functional groups that will complex or combine with an MR imaging enhancing element or ion. The compound is intended to include such complexes and combinations and includes the use of such compounds for MR imaging and photodynamic therapy treatment of tumors and other hyperproliferative tissue.

Abstract translation: 包括光动力四吡咯化合物与多个放射性核素元素原子的化学组合的化合物，使得该化合物可用于增强MR成像，并且还可用作光动力学化合物用于光动力学治疗以治疗过度增生组织。 优选的化合物具有以下结构式：其中R1，R2，R2a R3，R3a R4，R5，R5a R6，R7，R7a和R8累积含有至少两个将与MR成像增强元素或离子复合或组合的官能团 。 该化合物旨在包括这种复合物和组合，并且包括使用这些化合物用于肿瘤和其它过度增生组织的MR成像和光动力治疗治疗。