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公开(公告)号：US20180146650A1
公开(公告)日：2018-05-31
申请号：US15823036
申请日：2017-11-27
Applicant: LISA PORTER , BRE-ANNE FIFIELD , DOROTA LUBANSKA
Inventor： LISA PORTER , BRE-ANNE FIFIELD , DOROTA LUBANSKA
IPC: A01K67/027 , A61K49/00
CPC classification number: A01K67/0278 , A01K67/0275 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2227/105 , A01K2267/0331 , A61K49/0008 , C07K14/005 , C12N2740/12022
Abstract: In one aspect, the invention provides a transgenic non-human animal model having germ cells and somatic cells containing an endogenous MMTV-SV40-Spy1A gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage, wherein said gene sequence comprises a mouse mammary tumor virus gene (MMTV), a functionally disrupted SV40 gene (SV40) and a human Spy1A gene. In another aspect, the present invention provides a transgenic non-human animal model whose germ cells and somatic cells contain an endogenous Spy1A-pTRE-Tight gene sequence introduced into said animal model or an ancestor of said animal model at an embryonic stage. Preferably, the Spy1A-pTRE-Tight animal model expresses the Spy1A gene and develop cancer, preferably breast cancer, when administered with tetracycline, preferably doxycycline.
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公开(公告)号：US20180142004A1
公开(公告)日：2018-05-24
申请号：US15868885
申请日：2018-01-11
Applicant: Merus N.V.
Inventor： Ton LOGTENBERG , Rui Daniel PINTO , Erwin HOUTZAGER
CPC classification number: C07K16/1282 , A01K67/027 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K16/248 , C07K2317/24 , C12N15/8509 , C12P21/00
Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
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公开(公告)号：US20180142002A1
公开(公告)日：2018-05-24
申请号：US15863787
申请日：2018-01-05
Applicant: Merus N.V.
Inventor： Ton LOGTENBERG , Mark THROSBY , Robert A. KRAMER , Rui Daniel PINTO , Cornelis A. DE KRUIF , Erwin HOUTZAGER
CPC classification number: C07K16/1282 , A01K67/027 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K16/248 , C07K2317/24 , C12N15/8509 , C12P21/00
Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
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94.发明授权公开(公告)号：US09974289B2
公开(公告)日：2018-05-22
申请号：US15074920
申请日：2016-03-18
Inventor： Benjamin Levine Ebert , Jan Krönke , Steven A. Carr , Namrata D. Udeshi , Emma Fink
IPC: A01K67/027 , G01N33/00 , C12Q1/68 , G01N33/50 , G01N33/574 , G01N33/94
CPC classification number: A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/03 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/5011 , G01N33/5088 , G01N33/57496 , G01N33/94 , G01N2333/47
Abstract: The present invention features a knock-in mouse comprising a mutation in an endogenous CRBN locus and methods of use thereof.
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公开(公告)号：US20180134770A1
公开(公告)日：2018-05-17
申请号：US15870621
申请日：2018-01-12
Applicant: Merus N.V.
Inventor： Ton LOGTENBERG , Mark THROSBY , Robert A. KRAMER , Rui D. PINTO , Cornelis A. DE KRUIF , Erwin HOUTZAGER
CPC classification number: C07K16/1282 , A01K67/027 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/01 , C07K14/47 , C07K16/248 , C07K2317/24 , C12N15/8509 , C12P21/00
Abstract: Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human, human-like, or humanized. The nucleic acid is provided with a means that renders it resistant to DNA rearrangements and/or somatic hypermutations. In one embodiment, the nucleic acid comprises an expression cassette for the expression of a desired molecule in cells during a certain stage of development in cells developing into mature B cells. Further provided is methods for producing an immunoglobulin from the transgenic, non-human animal.
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Patent Agency Ranking
公开(公告)号：US20180125042A1
公开(公告)日：2018-05-10
申请号：US15789648
申请日：2017-10-20
Inventor： Han Su Kim , Soo Yeon Jung , Hae Sang Park
IPC: A01K67/027
CPC classification number: A01K67/0275 , A01K67/027 , A01K2207/25 , A01K2207/30 , A01K2227/105 , A01K2267/03 , C12N2015/8527
Abstract: The present invention relates to an animal model having hypoparathyroidism and a method for producing the same. According to the present invention, the animal model having hypoparathyroidism is economical and efficient in that it can demonstrate a pathophysiology of hypoparathyroidism and maintain a survival of animals without any distortion of the pathophysiology by supplying an optimal calcium content diet.
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公开(公告)号：US09963501B2
公开(公告)日：2018-05-08
申请号：US14174563
申请日：2014-02-06
Applicant: Regeneron Pharmaceuticals, Inc. , Duke University
Inventor： Barton Haynes , Garnett Kelsoe , Israel Lowy , Aris I. Baras , Lynn MacDonald , John McWhirter , Cagan Gurer , Karolina A. Meagher , Andrew J. Murphy , George D. Yancopoulos
IPC: C07K16/10 , A01K67/027
CPC classification number: C07K16/1045 , A01K67/0278 , A01K2217/072 , A01K2227/105 , A01K2267/01 , C07K16/10 , C07K16/1018 , G01N2500/00
Abstract: Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-lineage immunogen design in vaccine development are provided, as are methods of carrying out such design.
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公开(公告)号：US20180119169A1
公开(公告)日：2018-05-03
申请号：US15709822
申请日：2017-09-20
Applicant: Korea Institute of Science and Technology
Inventor： Do Hee KIM , Seul Gi Shin , Sung Su Lim , Ae Nim Pae , Dong Jin Kim , Yun Kyung Kim
IPC: C12N15/85 , A01K67/027 , G01N33/50 , C07K14/47 , G01N33/68
CPC classification number: C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/05 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C07K14/47 , C07K2319/60 , C12N2015/8527 , C12N2015/8536 , C12N2015/859 , C12N2830/008 , G01N33/5058 , G01N33/5088 , G01N33/6896 , G01N2800/2814
Abstract: Disclosed is a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
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公开(公告)号：US20180118820A1
公开(公告)日：2018-05-03
申请号：US15541889
申请日：2016-01-12
Applicant: CRESCENDO BIOLOGICS LIMITED
Inventor： Bryan EDWARDS , Ulla LASHMAR , Brian MCGUINNESS , Mike ROMANOS , Thomas SANDAL , Yumin TENG
CPC classification number: C07K16/244 , A01K67/0278 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K2039/505 , A61P31/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N33/6869 , G01N2333/54
Abstract: Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
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公开(公告)号：US20180110880A1
公开(公告)日：2018-04-26
申请号：US15111730
申请日：2015-01-15
Applicant: KYOTO UNIVERSITY
Inventor： Masamichi YAMAMOTO
IPC: A61K49/00 , C12N9/14 , A01K67/027 , C12N15/85
CPC classification number: A61K49/0008 , A01K67/0275 , A01K2217/07 , A01K2217/072 , A01K2217/15 , A01K2217/20 , A01K2227/105 , A01K2267/0356 , A01K2267/0375 , A01K2267/0393 , C07K2319/60 , C12N9/14 , C12N15/8509 , C12N15/907 , C12N2015/8527 , C12N2830/00 , C12N2830/15 , C12Y306/03
Abstract: Provided are a transgenic non-human mammal expressing a fusion protein, wherein the fusion protein comprises an ε subunit of an ATP synthase and two distinct fluorescent proteins as a donor and an acceptor for FRET, one of the fluorescent proteins being placed at an amino terminal moiety of the ε subunit and the other being placed at a carboxyl terminal moiety of the ε subunit, and a method of screening for an agent for preventing or treating diseases in a mammal in need thereof, comprising using an above transgenic non-human mammal.
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