公开(公告)号：US08996129B2

公开(公告)日：2015-03-31

申请号：US11669512

申请日：2007-01-31

Applicant: Lea A Nygren

Inventor： Lea A Nygren

IPC: A61N1/05 ,  A61B5/042 ,  C23C14/00 ,  C23C14/02 ,  C23C14/08

CPC classification number: A61N1/0565 ,  A61B5/042 ,  A61B2562/125 ,  A61N1/05 ,  A61N1/056 ,  C23C14/0036 ,  C23C14/028 ,  C23C14/08 ,  C23C14/085 ,  C23C14/35

Abstract: An implantable medical electrode includes a substrate and an iridium oxide surface, which is formed by an iridium oxide film applied over a roughened surface of the substrate. The film is preferably applied via direct current magnetron sputtering in a sputtering atmosphere comprising argon and oxygen. A sputtering target power may be between approximately 80 watts and approximately 300 watts, and a total sputtering pressure may be between approximately 9 millitorr and approximately 20 millitorr. The iridium oxide film may have a thickness greater than or equal to approximately 15,000 angstroms and have a microstructure exhibiting a columnar growth pattern.

Abstract translation: 可植入医疗电极包括基材和氧化铱表面，其由施加在基材的粗糙化表面上的氧化铱膜形成。 该膜优选通过直流磁控溅射在包含氩和氧的溅射气氛中进行。 溅射靶功率可以在约80瓦特和约300瓦特之间，并且总溅射压力可以在约9毫托和约20毫托之间。 氧化铱膜可以具有大于或等于约15,000埃的厚度，并且具有显示柱状生长图案的微结构。

公开(公告)号：US08948881B2

公开(公告)日：2015-02-03

申请号：US11750597

申请日：2007-05-18

Applicant: Andrew E. Fisk

Inventor： Andrew E. Fisk

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0565

Abstract: An implantable electrode comprising a substrate supporting microscopic surface structures such as columnar titanium nitride and further having nanoscopic surface structures on titanium nitride deposited on the exposed surface of the microscopic columnar structures is described. This is done through physical vapor deposition (PVD) and is based upon a relatively abrupt change in the surface mobility of the depositing material with a consequential variation in nucleation site density and surface mobility. At low mobility, there are increased nucleation sites and the condensation features are more numerous and finer. As mobility of the deposited species increases, the nucleation sites in the condensate film become fewer with coarser features. Consequently, the change from a relatively coarse microscopic surface structure to a relatively fine nanoscopic surface structure is accomplished by abruptly changing the total gas pressure in the processing chamber within a relatively short period of time of about ten seconds, or less.

Abstract translation: 描述了一种可植入电极，其包括支撑诸如柱状氮化钛的微观表面结构的基底，并且还在纳米级表面结构上沉积在微观柱状结构的暴露表面上的氮化钛上。 这是通过物理气相沉积（PVD）完成的，并且基于沉积材料的表面迁移率的相对突然的变化，并导致成核位点密度和表面迁移率的相应变化。 在低流动性下，增加了核化点，缩合特征更加多样化。 随着沉积物质的迁移率增加，冷凝膜中的成核位置随着较粗糙的特征变得更少。 因此，从相当粗糙的微观表面结构到相对精细的纳米表面结构的变化是通过在大约十秒或更短的相对短的时间段内突然改变处理室中的总气体压力来实现的。

公开(公告)号：US20140358160A1

公开(公告)日：2014-12-04

申请号：US14290718

申请日：2014-05-29

Applicant: SORIN CRM SAS

Inventor： Willy RÉGNIER ,  Nicolas SHAN ,  Jean-François OLLIVIER

IPC: A61N1/05 ,  A61M25/00

CPC classification number: A61N1/0565 ,  A61M25/0021 ,  A61M2025/0042 ,  A61N1/056 ,  A61N1/362 ,  A61N1/372

Abstract: This system includes a conductor microcable and an insulating microcatheter, including a hollow tube housing the microcable with the possibility of relative axial translation therebetween. The microcatheter is suitable for permanent implantation. The microcatheter, in its distal portion, includes at least one lateral window formed by a through orifice formed on the wall of the hollow tube. The window forms a stimulation site defined on the wall of the target vein facing the window of the microcatheter, and provides for a region of the microcable surface located at the window to form a stimulation electrode. In its distal portion, the microcable is not isolated at least in the region of the window of the microcatheter. The microcatheter is telescopically moveable on the microcable, so as to modify the position of the stimulation site of the target vein.

Abstract translation: 该系统包括导体微电缆和绝缘微导管，其包括容纳微电缆的中空管，其间具有相对轴向平移的可能性。 微导管适用于永久植入。 微导管在其远端部分包括由形成在中空管的壁上的通孔形成的至少一个侧向窗口。 窗口形成在面向微导管窗口的目标静脉的壁上限定的刺激部位，并且提供位于窗口处的微循环表面的区域以形成刺激电极。 至少在微导管的窗口的区域中，微电缆在远端部分不分离。 微导管可伸缩地移动到微电缆上，以便改变目标静脉刺激部位的位置。

公开(公告)号：US20140236172A1

公开(公告)日：2014-08-21

申请号：US14264663

申请日：2014-04-29

Applicant: Cardiac Pacemakers, Inc.

Inventor： Roger Hastings ,  John A. Becker ,  Michael J. Pikus ,  Daniel M. Lafontaine ,  Kevin D. Edmunds

IPC: A61N1/05

CPC classification number: A61N1/3787 ,  A61N1/0565 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3684 ,  A61N1/37205 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/3756

Abstract: A wireless electrostimulation system can comprise a wireless energy transmission source, and an implantable cardiovascular wireless electrostimulation node. A receiver circuit comprising an inductive antenna can be configured to capture magnetic energy to generate a tissue electrostimulation. A tissue electrostimulation circuit, coupled to the receiver circuit, can be configured to deliver energy captured by the receiver circuit as a tissue electrostimulation waveform. Delivery of tissue electrostimulation can be initiated by a therapy control unit.

Abstract translation: 无线电刺激系统可以包括无线能量传输源和可植入心血管无线电刺激节点。 包括感应天线的接收机电路可被配置为捕获磁能以产生组织电刺激。 耦合到接收器电路的组织电刺激电路可以被配置为将由接收器电路捕获的能量作为组织电刺激波形传送。 组织电刺激的递送可以由治疗控制单元启动。

公开(公告)号：US20140221809A1

公开(公告)日：2014-08-07

申请号：US14223320

申请日：2014-03-24

Applicant: Cardiac Pacemakers, Inc.

Inventor： Paul E. Zarembo ,  Elliott Rodriguez Roman

IPC: A61B5/04 ,  A61N1/04

CPC classification number: A61B5/04 ,  A61N1/04 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/0587 ,  H01R13/5224 ,  Y10T29/49172

Abstract: A lead assembly includes a ring component having mechanical coupling features, and at least one polymer component mechanically coupled with the mechanical coupling features of the ring component. Elongate tubing is disposed over the polymer component and is secured with the polymer component.

Abstract translation: 导线组件包括具有机械耦合特征的环组件和与环组件的机械耦合特征机械耦合的至少一个聚合物组件。 细长管被设置在聚合物组分上并用聚合物组分固定。

公开(公告)号：US08798738B2

公开(公告)日：2014-08-05

申请号：US13654525

申请日：2012-10-18

Applicant: The Cleveland Clinic Foundation

Inventor： Sandra Machado ,  Marc Penn ,  Ali R. Rezai

IPC: A61N1/365

CPC classification number: A61N1/0565 ,  A61B18/1492 ,  A61B2018/00267 ,  A61B2018/00351 ,  A61B2018/00577 ,  A61B2018/00648 ,  A61B2018/00827 ,  A61B2018/00892 ,  A61M5/14212 ,  A61N1/0568 ,  A61N1/36114 ,  A61N1/3627 ,  A61N1/36585

Abstract: Methods of treating acute heart failure in a patient in need thereof. Methods include inserting a therapy delivery device into a pulmonary artery of the patient and applying a therapy signal to autonomic cardiopulmonary fibers surrounding the pulmonary artery. The therapy signal affects heart contractility more than heart rate. Specifically, the application of the therapy signal increases heart contractility and treats the acute heart failure in the patient. The therapy signal can include electrical or chemical modulation.

Abstract translation: 在有需要的患者中治疗急性心力衰竭的方法。 方法包括将治疗递送装置插入到患者的肺动脉中，并将治疗信号施加到围绕肺动脉的自主心肺纤维。 治疗信号影响心脏收缩力超过心率。 具体来说，治疗信号的应用增加了心脏收缩力，并治疗了患者的急性心力衰竭。 治疗信号可以包括电或化学调节。

公开(公告)号：US08792993B2

公开(公告)日：2014-07-29

申请号：US13906776

申请日：2013-05-31

Applicant: Boston Scientific Neuromodulation Corporation

Inventor： Anne Margaret Pianca ,  Joshua Dale Howard ,  William George Orinski

IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61N1/05 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/3605

Abstract: An implantable electrical stimulation lead includes a tip electrode disposed on a distal tip of the lead body. One tip electrode has a base and a separate plug attached to the base. The base defines an interior lumen closed at one end by the plug. Another tip electrode has an electrode body, a stem extending from the electrode body, and shaped retention features extending from the stem. Yet another tip electrode has an electrode body, a stem extending from the electrode body, and a flange disposed on the stem opposite the electrode body. A further tip electrode has an electrode body defining an interior lumen and a plurality of protrusions extending into the interior lumen. Another tip electrode has an electrode body and arms extending from the electrode body. The electrode body defines an interior lumen and the arms extend over an opening to the interior lumen.

Abstract translation: 可植入电刺激引线包括设置在引线主体的远端上的尖端电极。 一个尖端电极具有底座和附接到基座的单独插头。 底座限定了一端通过插头封闭的内腔。 另一个尖端电极具有电极体，从电极本体延伸的杆以及从杆延伸的成形保持特征。 另一个尖端电极具有电极体，从电极主体延伸的杆，以及设置在与杆体相对的电极体上的凸缘。 另一个尖端电极具有限定内腔的电极体和延伸到内腔中的多个突起。 另一个尖端电极具有电极体和从电极体延伸的臂。 电极体限定内腔，并且臂延伸到内腔内的开口上。

公开(公告)号：US20130325091A1

公开(公告)日：2013-12-05

申请号：US13906776

申请日：2013-05-31

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： Anne Margaret Pianca ,  Joshua Dale Howard ,  William George Orinski

IPC: A61N1/05

CPC classification number: A61N1/05 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/3605

Abstract: An implantable electrical stimulation lead includes a tip electrode disposed on a distal tip of the lead body. One tip electrode has a base and a separate plug attached to the base. The base defines an interior lumen closed at one end by the plug. Another tip electrode has an electrode body, a stem extending from the electrode body, and shaped retention features extending from the stem. Yet another tip electrode has an electrode body, a stem extending from the electrode body, and a flange disposed on the stem opposite the electrode body. A further tip electrode has an electrode body defining an interior lumen and a plurality of protrusions extending into the interior lumen. Another tip electrode has an electrode body and arms extending from the electrode body. The electrode body defines an interior lumen and the arms extend over an opening to the interior lumen.

Abstract translation: 可植入电刺激引线包括设置在引线主体的远端上的尖端电极。 一个尖端电极具有底座和附接到基座的单独插头。 底座限定了一端通过插头封闭的内腔。 另一个尖端电极具有电极体，从电极本体延伸的杆以及从杆延伸的成形保持特征。 另一个尖端电极具有电极体，从电极主体延伸的杆，以及设置在与杆体相对的电极体上的凸缘。 另一个尖端电极具有限定内腔的电极体和延伸到内腔中的多个突起。 另一个尖端电极具有电极体和从电极体延伸的臂。 电极体限定内腔，并且臂延伸到内腔内的开口上。

公开(公告)号：US20130110216A1

公开(公告)日：2013-05-02

申请号：US13527836

申请日：2012-06-20

Applicant: YU-QUAN WANG ,  LI QIAN ,  LIANG LIU ,  CHEN FENG ,  LI FAN ,  WEN-MEI ZHAO

Inventor： YU-QUAN WANG ,  LI QIAN ,  LIANG LIU ,  CHEN FENG ,  LI FAN ,  WEN-MEI ZHAO

IPC: A61N1/05 ,  A61N1/36 ,  B82Y5/00

CPC classification number: A61N1/056 ,  A61N1/05 ,  A61N1/0565 ,  A61N1/362 ,  B82Y30/00

Abstract: An electrode lead of a pacemaker includes a metal conductive core and a carbon nanotube film. The metal conductive core defines an extending direction. The carbon nanotube film wraps around the metal conductive core. The carbon nanotube film includes a plurality of carbon nanotubes extending substantially along the extending direction of the metal conductive core. A bared part is defined at one end of the electrode lead. A pacemaker using the above mentioned electrode lead is also disclosed.

Abstract translation: 起搏器的电极引线包括金属导电芯和碳纳米管膜。 金属导电芯限定延伸方向。 碳纳米管膜缠绕在金属导电芯上。 碳纳米管膜包括基本沿着金属导电芯的延伸方向延伸的多个碳纳米管。 裸电极定义在电极引线的一端。 还公开了使用上述电极引线的起搏器。

公开(公告)号：US08380306B2

公开(公告)日：2013-02-19

申请号：US13193866

申请日：2011-07-29

Applicant: Christopher John Pickett

Inventor： Christopher John Pickett

IPC: A61N1/00

CPC classification number: A61N1/056 ,  A61N1/0565 ,  A61N1/362 ,  C08G2261/3221 ,  C08G2261/3223 ,  C09D5/24 ,  C09D5/4476 ,  C25D7/00 ,  C25D13/04

Abstract: An implantable electrode, for an implantable tissue stimulator, has an electrically conductive porous material comprising metal carbide, metal nitride, metal carbonitride, metal oxide or metal oxynitride and one or more coating layers on a surface thereof. The coating layer or at least one of the coating layers, is for contact with body tissue when the electrode is implanted. Each coating layer is an electrically conductive layer of polymer having a polypyrrole polymeric backbone or polythiophene polymeric backbone. The coating layer or layers are formed in situ by electropolymerisation. The polypyrrole or polythiophene may be substituted. The coating layer or layers can provide high charge storage capacitance and a fast discharging profile, as well as biocompatibility.

Abstract translation: 用于可植入组织刺激器的可植入电极具有包含金属碳化物，金属氮化物，金属碳氮化物，金属氧化物或金属氮氧化物的导电多孔材料以及其表面上的一个或多个涂层。 当植入电极时，涂层或至少一个涂层用于与身体组织接触。 每个涂层是具有聚吡咯聚合物主链或聚噻吩聚合物主链的聚合物导电层。 通过电聚合原位形成涂层。 聚吡咯或聚噻吩可以是取代的。 涂层可以提供高电荷储存电容和快速放电曲线以及生物相容性。