公开(公告)号：US12077562B2

公开(公告)日：2024-09-03

申请号：US17930166

申请日：2022-09-07

Applicant: University of Massachusetts ,  The Johns Hopkins University ,  Kennedy Krieger Institute, Inc.

Inventor： Miguel Sena Esteves ,  Sourav Roy Choudhury ,  Kathryn Rae Wagner ,  Jennifer Gifford Green ,  Ana Rita Batista

IPC: C07K14/01 ,  C07K14/005 ,  C07K14/015 ,  C07K14/47 ,  C12N7/00 ,  A61K38/00

CPC classification number: C07K14/01 ,  C12N7/00 ,  A61K38/00 ,  C12N2310/141 ,  C12N2750/14122

Abstract: The disclosure relates, in some aspects, to adeno-associated virus capsid proteins isolated from an in vivo library and recombinant adeno-associated viruses (rAAVs) comprising the same. In some aspects, the disclosure relates to isolated nucleic acids encoding AAV capsid proteins isolated from an in vivo library. In some embodiments, rAAVs and compositions described by the disclosure are useful for delivery of one or more transgenes to the muscle-tissue of a subject.

公开(公告)号：US12076414B2

公开(公告)日：2024-09-03

申请号：US16856893

申请日：2020-04-23

Applicant: Johnson & Johnson Consumer Inc.

Inventor： Elizabeth Bruning ,  Anthony Robert Geonnotti, III ,  Euen Thomas Ekman-Gunn ,  Russel Walters ,  Alpana Oak ,  Frank C. Sun ,  Kimberly Capone ,  Frank J. Kirchner

IPC: A61K47/69 ,  A61K9/06 ,  A61K47/32 ,  C12N7/00

CPC classification number: A61K47/6903 ,  A61K47/32 ,  C12N7/00 ,  A61K9/06

Abstract: This invention relates to methods and compositions for inhibiting the transmission of enveloped viruses, which entails applying a composition containing a high molecular weight hydrophobically-modified polymer to an infectable or ingestible surface that may contain viruses and wherein said anti-viral composition is substantially free of surfactant having an HLB greater than about 12.

公开(公告)号：US12076391B2

公开(公告)日：2024-09-03

申请号：US18177413

申请日：2023-03-02

Applicant: YISHENG BIOPHARMA (SINGAPORE) PTE. LTD.

Inventor： Yi Zhang ,  Yuhe Yan ,  Xu Zhang ,  Thomas Anthony Coton

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  C12N5/00 ,  C12N7/00

CPC classification number: A61K39/145 ,  C12N7/00 ,  C12N2760/16152

Abstract: A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.

公开(公告)号：US12076353B2

公开(公告)日：2024-09-03

申请号：US16763013

申请日：2018-11-23

Applicant: Ottawa Hospital Research Institute

Inventor： Jean-Simon Diallo ,  Mohammed Selman ,  Rozanne Arulanandam ,  Nicole Elise Forbes ,  Ramya Krishnan

IPC: C12N7/00 ,  A61K31/225 ,  A61K35/766 ,  A61P35/00 ,  C07C69/60 ,  A61K39/00

CPC classification number: A61K35/766 ,  A61K31/225 ,  A61P35/00 ,  C07C69/60 ,  C12N7/00 ,  A61K2039/585 ,  C12N2710/10332 ,  C12N2710/10351 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/20232 ,  C12N2760/20251

Abstract: Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.

公开(公告)号：US20240287473A1

公开(公告)日：2024-08-29

申请号：US18660408

申请日：2024-05-10

Applicant: AGC INC.

Inventor： Kaya OHTAKI ,  Mayumi OKAMOTO ,  Shunsuke SHIINA

IPC: C12N7/00 ,  B01D15/08 ,  B01D61/14

CPC classification number: C12N7/00 ,  B01D15/08 ,  B01D61/145 ,  C12N2750/14151

Abstract: A method for purifying a virus, including an ultrafiltration step, which can purify the virus more conveniently with a high purity is provided by the present invention. Virus can be obtained in a high yield by ultrafiltration of an aqueous dispersion containing the virus, a surfactant, and an inorganic salt.

公开(公告)号：US20240287471A1

公开(公告)日：2024-08-29

申请号：US18646957

申请日：2024-04-26

Applicant: Prevail Therapeutics, Inc.

Inventor： Asa ABELIOVICH ,  Laura HECKMAN ,  Herve RHINN ,  Li Chin WONG ,  Hsuan-Ni LIN ,  Franz HEFTI

IPC: C12N7/00 ,  A61K48/00 ,  A61P25/28 ,  C07K14/435 ,  C12N9/02 ,  G01N33/68

CPC classification number: C12N7/00 ,  A61K48/0075 ,  A61K48/0083 ,  A61P25/28 ,  C07K14/435 ,  C12N9/0071 ,  C12Y114/18001 ,  G01N33/6803 ,  C12N2750/14132 ,  C12N2750/14133 ,  C12N2750/14143 ,  G01N2333/435

Abstract: The disclosure relates to compositions and methods for treatment of diseases associated with aberrant lysosomal function, such as fronto-temporal dementia (FTD). The disclosure also provides expression constructs comprising a transgene encoding progranulin or a portion thereof. The disclosure provides methods of treating FTD by administering such expression constructs to a subject in need thereof.

公开(公告)号：US20240285734A1

公开(公告)日：2024-08-29

申请号：US18518270

申请日：2024-05-14

Applicant: Daniel Darvish

Inventor： Daniel Darvish

IPC: A61K38/47 ,  A61K9/00 ,  A61K38/17 ,  A61K38/45 ,  A61K45/06 ,  A61P21/04 ,  C12N7/00 ,  C12N9/12 ,  C12N9/24 ,  C12N15/86

CPC classification number: A61K38/47 ,  A61K9/0019 ,  A61K38/17 ,  A61K38/45 ,  A61K45/06 ,  A61P21/04 ,  C12N7/00 ,  C12N9/1205 ,  C12N9/2402 ,  C12N15/86 ,  C12Y207/0106 ,  C12Y302/01183 ,  C12N2750/14143

Abstract: The invention relates to composition and methods for expressing UDP-GlcNAc 2-Epimerase/ManNAc Kinase enzyme (GNE) in a living organism. In preferred embodiments, the invention relates to treating disease condition that involves use of therapeutically effective amount of a composition described herein.

公开(公告)号：US12070478B2

公开(公告)日：2024-08-27

申请号：US18115066

申请日：2023-02-28

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Nicole F. Steinmetz ,  Karin L. Lee

IPC: A61K35/76 ,  A61K31/704 ,  A61K39/12 ,  A61K39/39 ,  A61P35/00 ,  C12N7/00 ,  A61K45/06

CPC classification number: A61K35/76 ,  A61K31/704 ,  A61K39/12 ,  A61K39/39 ,  A61P35/00 ,  A61K45/06 ,  C12N2770/26011 ,  C12N2770/26023 ,  C12N2770/26033 ,  C12N2770/26042 ,  C12N2770/40023

Abstract: A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.

公开(公告)号：US20240279685A1

公开(公告)日：2024-08-22

申请号：US18004403

申请日：2021-07-06

Applicant: FLAGSHIP PIONEERING INNOVATIONS V, INC.

Inventor： Benhur Lee ,  Michael Travis Mee ,  Jagesh V. Shah ,  Kyle Marvin Trudeau

IPC: C12N15/88 ,  A61K9/51 ,  C07K14/005 ,  C12N5/071 ,  C12N7/00

CPC classification number: C12N15/88 ,  A61K9/5184 ,  C07K14/005 ,  C12N5/0602 ,  C12N7/00 ,  C12N2740/16043 ,  C12N2760/18222

Abstract: The present disclosure provides, at least in part, methods and compositions for producing fusosomes. In some embodiments, a producer cell for producing fusosomes comprises an exogenous or overexpresed cathepsin molecule. In some embodiments, these cells generate an increased level of active fusogen, leading to a higher proportion of fusogenically active fusosomes.

公开(公告)号：US20240277869A1

公开(公告)日：2024-08-22

申请号：US18571367

申请日：2022-06-17

Applicant: DYNO THERAPEUTICS, INC.

Inventor： Sylvain Lapan ,  Hanna Levitin

IPC: A61K48/00 ,  C07K14/005 ,  C12N7/00

CPC classification number: A61K48/0041 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14122 ,  C12N2750/14151

Abstract: The disclosure is directed in part to variant capsid polypeptides that can be used to deliver payloads.